FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096015108> ?p ?o ?g. }

• W2096015108 endingPage "82" @default.
• W2096015108 startingPage "75" @default.
• W2096015108 abstract "Metastasis is the leading cause of cancer death, yet it is mechanistically considered a very inefficient process suggesting the presence of some sort of (e.g. systemic) routes for fuelling the process. The pre-metastatic niche formation is described as one such metastasis promoting route. Now, the emerging potentials of tumor-derived microvesicles (TDMVs), not only in formulating the pre-metastatic niche, but also conferring neoplastic phenotypes onto normal cells, has integrated new concepts into the field. Here, we note as an ancillary proposition that, exerting functional disturbances in other sites, TDMVs (we have termed them metastasomes) may aid foundation of the secondary lesions via two seemingly interrelated models: (i) tumor-organ-training (TOTr), training a proper niche for the growth of the disseminated tumor cells; (ii) tumor-organ-targeting (TOTa), contribution to the propagation of the transformed phenotype via direct or indirect (TOTr-mediated disturbed stroma) transformation and/or heightened growth/survival states of the normal resident cells in the secondary organs. Respecting the high content of the RNA molecules (particularly microRNAs) identified in the secretory MVs, they may play crucial parts in such “malignant trait” spreading system. That is, the interactions between tumor tissue-specific RNA signatures, being transferred via metastasomes, and the cell-type/tissue-specific RNA stockrooms in other areas may settle a unique outcome in each organ. Thus, serving as tumor-organ matchmakers, the RNA molecules may also play substantial roles in the seeding and tropism of the process." @default.
• W2096015108 created "2016-06-24" @default.
• W2096015108 creator A5012371091 @default.
• W2096015108 creator A5027075905 @default.
• W2096015108 creator A5029630690 @default.
• W2096015108 creator A5046997933 @default.
• W2096015108 creator A5055119992 @default.
• W2096015108 creator A5072059804 @default.
• W2096015108 creator A5074658386 @default.
• W2096015108 date "2013-01-01" @default.
• W2096015108 modified "2023-09-23" @default.
• W2096015108 title "Tumor-derived microvesicles: The metastasomes" @default.
• W2096015108 cites W1511964634 @default.
• W2096015108 cites W1762620449 @default.
• W2096015108 cites W1925340186 @default.
• W2096015108 cites W1964232997 @default.
• W2096015108 cites W1966194317 @default.
• W2096015108 cites W1967367827 @default.
• W2096015108 cites W1967828169 @default.
• W2096015108 cites W1969002010 @default.
• W2096015108 cites W1974954833 @default.
• W2096015108 cites W1975859224 @default.
• W2096015108 cites W1979679866 @default.
• W2096015108 cites W1982255083 @default.
• W2096015108 cites W1984557698 @default.
• W2096015108 cites W1984933192 @default.
• W2096015108 cites W1986471913 @default.
• W2096015108 cites W1987409881 @default.
• W2096015108 cites W1991293757 @default.
• W2096015108 cites W1991390602 @default.
• W2096015108 cites W1995827114 @default.
• W2096015108 cites W1996877529 @default.
• W2096015108 cites W1998802762 @default.
• W2096015108 cites W2000302106 @default.
• W2096015108 cites W2003321071 @default.
• W2096015108 cites W2004630197 @default.
• W2096015108 cites W2007040134 @default.
• W2096015108 cites W2007897263 @default.
• W2096015108 cites W2010069724 @default.
• W2096015108 cites W2015039954 @default.
• W2096015108 cites W2019888542 @default.
• W2096015108 cites W2022027327 @default.
• W2096015108 cites W2029861487 @default.
• W2096015108 cites W2030701238 @default.
• W2096015108 cites W2034550273 @default.
• W2096015108 cites W2035844407 @default.
• W2096015108 cites W2037872626 @default.
• W2096015108 cites W2039685596 @default.
• W2096015108 cites W2039854218 @default.
• W2096015108 cites W2046387002 @default.
• W2096015108 cites W2047197808 @default.
• W2096015108 cites W2048883725 @default.
• W2096015108 cites W2049528074 @default.
• W2096015108 cites W2051512394 @default.
• W2096015108 cites W2051678321 @default.
• W2096015108 cites W2054077259 @default.
• W2096015108 cites W2054410308 @default.
• W2096015108 cites W2055313665 @default.
• W2096015108 cites W2056899778 @default.
• W2096015108 cites W2059266855 @default.
• W2096015108 cites W2061104922 @default.
• W2096015108 cites W2061996203 @default.
• W2096015108 cites W2062249523 @default.
• W2096015108 cites W2062265555 @default.
• W2096015108 cites W2063480251 @default.
• W2096015108 cites W2063508984 @default.
• W2096015108 cites W2063910973 @default.
• W2096015108 cites W2076495609 @default.
• W2096015108 cites W2076633238 @default.
• W2096015108 cites W2078424563 @default.
• W2096015108 cites W2080232352 @default.
• W2096015108 cites W2080264320 @default.
• W2096015108 cites W2084271408 @default.
• W2096015108 cites W2084601974 @default.
• W2096015108 cites W2086702591 @default.
• W2096015108 cites W2087487150 @default.
• W2096015108 cites W2090412820 @default.
• W2096015108 cites W2090664398 @default.
• W2096015108 cites W2092868756 @default.
• W2096015108 cites W2094077020 @default.
• W2096015108 cites W2110576880 @default.
• W2096015108 cites W2112187582 @default.
• W2096015108 cites W2119043140 @default.
• W2096015108 cites W2119259865 @default.
• W2096015108 cites W2120587170 @default.
• W2096015108 cites W2128214810 @default.
• W2096015108 cites W2129802808 @default.
• W2096015108 cites W2141138739 @default.
• W2096015108 cites W2143253053 @default.
• W2096015108 cites W2144744111 @default.
• W2096015108 cites W2146530991 @default.
• W2096015108 cites W2147352070 @default.
• W2096015108 cites W2149687327 @default.
• W2096015108 cites W2150575159 @default.
• W2096015108 cites W2160436654 @default.
• W2096015108 cites W2165200432 @default.
• W2096015108 cites W2165374397 @default.
• W2096015108 cites W2170449834 @default.

• next