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- W2096028552 endingPage "489" @default.
- W2096028552 startingPage "482" @default.
- W2096028552 abstract "Many lung and central nervous system disorders require robust and appropriate physiological responses to assure adequate breathing. Factors undermining the efficacy of ventilatory control will diminish the ability to compensate for pathology, threatening life itself. Although most of these same disorders are associated with systemic and/or neuroinflammation, and inflammation affects neural function, we are only beginning to understand interactions between inflammation and any aspect of ventilatory control (e.g. sensory receptors, rhythm generation, chemoreflexes, plasticity). Here we review available evidence, and present limited new data suggesting that systemic (or neural) inflammation impairs two key elements of ventilatory control: chemoreflexes and respiratory motor (versus sensory) plasticity. Achieving an understanding of mechanisms whereby inflammation undermines ventilatory control is fundamental since inflammation may diminish the capacity for natural, compensatory responses during pathological states, and the ability to harness respiratory plasticity as a therapeutic strategy in the treatment of devastating breathing disorders, such as during cervical spinal injury or motor neuron disease." @default.
- W2096028552 created "2016-06-24" @default.
- W2096028552 creator A5013363795 @default.
- W2096028552 creator A5026070732 @default.
- W2096028552 creator A5031164979 @default.
- W2096028552 creator A5038094924 @default.
- W2096028552 creator A5046178403 @default.
- W2096028552 creator A5053874663 @default.
- W2096028552 creator A5084518388 @default.
- W2096028552 date "2011-09-01" @default.
- W2096028552 modified "2023-09-27" @default.
- W2096028552 title "Systemic inflammation impairs respiratory chemoreflexes and plasticity" @default.
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