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• W2096040006 abstract "Pulmonary hypertension (PH) is a common complication of chronic obstructive pulmonary disease (COPD). Ghrelin is an orexigenic hormone and endogenous vasodilatory peptide; however, no data exists on the potential role of ghrelin in PH secondary to COPD. It was aimed to determine serum ghrelin, tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) levels in underweight and normal weight COPD patients with and without PH. Serum ghrelin, IL-6, and TNF-α levels were measured in underweight and normal weight 60 COPD patients with and without PH and in 15 healthy control subjects. IL-6, TNF-α and serum ghrelin levels were assessed by enzyme-linked immunosorbent assays (ELISA). Pulmonary artery pressure levels were measured by echocardiography. Serum IL-6 and TNF-α levels were significantly higher and ghrelin levels were significantly lower in COPD patients with or without PH compared to healthy control subjects. Serum ghrelin levels were statistically lower and IL-6 levels were higher in underweight COPD patients with PH than in underweight COPD patients without PH. No differences existed in serum ghrelin levels between the normal weight COPD patients with or without PH. Serum ghrelin levels were decreased in COPD patients with or without PH, particularly in underweight COPD patients with PH. It was concluded that ghrelin has a potential role in the development of PH, especially in underweight COPD patients." @default.
• W2096040006 created "2016-06-24" @default.
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• W2096040006 date "2010-01-01" @default.
• W2096040006 modified "2023-09-27" @default.
• W2096040006 title "Systemic inflammation and ghrelin levels in chronic obstructive pulmonary disease patients with and without pulmonary hypertension." @default.
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