FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096122705> ?p ?o ?g. }

• W2096122705 endingPage "9187" @default.
• W2096122705 startingPage "9175" @default.
• W2096122705 abstract "ABSTRACT Replication of the human herpesvirus Epstein-Barr virus drastically impairs cellular protein synthesis. This shutoff phenotype results from mRNA degradation upon expression of the early lytic-phase protein BGLF5. Interestingly, BGLF5 is the viral DNase, or alkaline exonuclease, homologues of which are present throughout the herpesvirus family. During productive infection, this DNase is essential for processing and packaging of the viral genome. In contrast to this widely conserved DNase activity, shutoff is only mediated by the alkaline exonucleases of the subfamily of gammaherpesviruses. Here, we show that BGLF5 can degrade mRNAs of both cellular and viral origin, irrespective of polyadenylation. Furthermore, shutoff by BGLF5 induces nuclear relocalization of the cytosolic poly(A) binding protein. Guided by the recently resolved BGLF5 structure, mutants were generated and analyzed for functional consequences on DNase and shutoff activities. On the one hand, a point mutation destroying DNase activity also blocks RNase function, implying that both activities share a catalytic site. On the other hand, other mutations are more selective, having a more pronounced effect on either DNA degradation or shutoff. The latter results are indicative of an oligonucleotide-binding site that is partially shared by DNA and RNA. For this, the flexible “bridge” that crosses the active-site canyon of BGLF5 appears to contribute to the interaction with RNA substrates. These findings extend our understanding of the molecular basis for the shutoff function of BGLF5 that is conserved in gammaherpesviruses but not in alpha- and betaherpesviruses." @default.
• W2096122705 created "2016-06-24" @default.
• W2096122705 creator A5010817206 @default.
• W2096122705 creator A5022691979 @default.
• W2096122705 creator A5038215233 @default.
• W2096122705 creator A5042316785 @default.
• W2096122705 creator A5051095634 @default.
• W2096122705 creator A5062280553 @default.
• W2096122705 creator A5071125946 @default.
• W2096122705 creator A5076608963 @default.
• W2096122705 date "2012-09-01" @default.
• W2096122705 modified "2023-10-13" @default.
• W2096122705 title "The “Bridge” in the Epstein-Barr Virus Alkaline Exonuclease Protein BGLF5 Contributes to Shutoff Activity during Productive Infection" @default.
• W2096122705 cites W1539798432 @default.
• W2096122705 cites W1606830172 @default.
• W2096122705 cites W1824684517 @default.
• W2096122705 cites W1883897672 @default.
• W2096122705 cites W1970905916 @default.
• W2096122705 cites W1975578460 @default.
• W2096122705 cites W1978202804 @default.
• W2096122705 cites W1981459273 @default.
• W2096122705 cites W1984331216 @default.
• W2096122705 cites W1985629904 @default.
• W2096122705 cites W2006900344 @default.
• W2096122705 cites W2011099846 @default.
• W2096122705 cites W2021743722 @default.
• W2096122705 cites W2023484815 @default.
• W2096122705 cites W2024149180 @default.
• W2096122705 cites W2026970642 @default.
• W2096122705 cites W2032527591 @default.
• W2096122705 cites W2034292826 @default.
• W2096122705 cites W2034407189 @default.
• W2096122705 cites W2040250369 @default.
• W2096122705 cites W2041041584 @default.
• W2096122705 cites W2054971075 @default.
• W2096122705 cites W2060261905 @default.
• W2096122705 cites W2062999927 @default.
• W2096122705 cites W2085610443 @default.
• W2096122705 cites W2086210810 @default.
• W2096122705 cites W2090204598 @default.
• W2096122705 cites W2098159895 @default.
• W2096122705 cites W2100324678 @default.
• W2096122705 cites W2102679846 @default.
• W2096122705 cites W2106882534 @default.
• W2096122705 cites W2108309503 @default.
• W2096122705 cites W2125207784 @default.
• W2096122705 cites W2128224294 @default.
• W2096122705 cites W2131881555 @default.
• W2096122705 cites W2138257095 @default.
• W2096122705 cites W2138717283 @default.
• W2096122705 cites W2138822872 @default.
• W2096122705 cites W2141068257 @default.
• W2096122705 cites W2143158937 @default.
• W2096122705 cites W2148874138 @default.
• W2096122705 cites W2154153723 @default.
• W2096122705 cites W2155790805 @default.
• W2096122705 cites W2158714788 @default.
• W2096122705 cites W2158859500 @default.
• W2096122705 cites W2159614853 @default.
• W2096122705 cites W2160051891 @default.
• W2096122705 cites W2160784460 @default.
• W2096122705 cites W2161780610 @default.
• W2096122705 cites W2163715074 @default.
• W2096122705 cites W2168494912 @default.
• W2096122705 cites W2169983462 @default.
• W2096122705 cites W2170036048 @default.
• W2096122705 cites W4232689224 @default.
• W2096122705 doi "https://doi.org/10.1128/jvi.00309-12" @default.
• W2096122705 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3416140" @default.
• W2096122705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22696660" @default.
• W2096122705 hasPublicationYear "2012" @default.
• W2096122705 type Work @default.
• W2096122705 sameAs 2096122705 @default.
• W2096122705 citedByCount "28" @default.
• W2096122705 countsByYear W20961227052013 @default.
• W2096122705 countsByYear W20961227052014 @default.
• W2096122705 countsByYear W20961227052015 @default.
• W2096122705 countsByYear W20961227052016 @default.
• W2096122705 countsByYear W20961227052017 @default.
• W2096122705 countsByYear W20961227052018 @default.
• W2096122705 countsByYear W20961227052019 @default.
• W2096122705 countsByYear W20961227052020 @default.
• W2096122705 countsByYear W20961227052021 @default.
• W2096122705 countsByYear W20961227052022 @default.
• W2096122705 countsByYear W20961227052023 @default.
• W2096122705 crossrefType "journal-article" @default.
• W2096122705 hasAuthorship W2096122705A5010817206 @default.
• W2096122705 hasAuthorship W2096122705A5022691979 @default.
• W2096122705 hasAuthorship W2096122705A5038215233 @default.
• W2096122705 hasAuthorship W2096122705A5042316785 @default.
• W2096122705 hasAuthorship W2096122705A5051095634 @default.
• W2096122705 hasAuthorship W2096122705A5062280553 @default.
• W2096122705 hasAuthorship W2096122705A5071125946 @default.
• W2096122705 hasAuthorship W2096122705A5076608963 @default.
• W2096122705 hasBestOaLocation W20961227051 @default.
• W2096122705 hasConcept C104317684 @default.
• W2096122705 hasConcept C10879258 @default.
• W2096122705 hasConcept C131140672 @default.

• next