FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096127904> ?p ?o ?g. }

• W2096127904 endingPage "1502" @default.
• W2096127904 startingPage "1495" @default.
• W2096127904 abstract "A complex network of interactions between the stroma, the extracellular matrix and the epithelium drives mammary gland development and function. Two main assumptions in chemical carcinogenesis of the mammary gland have been that carcinogens induce neoplasia by causing mutations in the DNA of the epithelial cells and that the alterations of tissue architecture observed in neoplasms are a consequence of this primary mutational event. Here, we use a rat mammary tissue recombination model and the chemical carcinogen N-nitrosomethylurea (NMU) to determine whether the primary target of the carcinogen is the epithelium, the stroma or both tissue compartments. Mammary epithelial cells were exposed in vitro either to the carcinogen or vehicle before being transplanted into the cleared fat pads of rats exposed to carcinogen or vehicle. We observed that neoplastic transformation of these mammary epithelial cells occurred only when the stroma was exposed in vivo to NMU, regardless of whether or not the epithelial cells were exposed to the carcinogen. Mammary epithelial cells exposed in vitro to the carcinogen formed phenotypically normal ducts when injected into a non-treated stroma. Mutation in the Ha-ras-1 gene did not correlate with initiation of neoplasia. Not only was it often found in both cleared mammary fat pads of vehicle-treated animals and intact mammary glands of untreated animals, but it was also absent in some tumors. Our results suggest that the stroma is a crucial target of the carcinogen and that mutation in the Ha-ras-1 gene is neither necessary nor sufficient for tumor initiation." @default.
• W2096127904 created "2016-06-24" @default.
• W2096127904 creator A5012489838 @default.
• W2096127904 creator A5027267648 @default.
• W2096127904 creator A5041133587 @default.
• W2096127904 creator A5047592144 @default.
• W2096127904 creator A5083196258 @default.
• W2096127904 date "2004-03-15" @default.
• W2096127904 modified "2023-10-11" @default.
• W2096127904 title "The stroma as a crucial target in rat mammary gland carcinogenesis" @default.
• W2096127904 cites W1482076735 @default.
• W2096127904 cites W1561534261 @default.
• W2096127904 cites W1971053488 @default.
• W2096127904 cites W1975648059 @default.
• W2096127904 cites W1990119700 @default.
• W2096127904 cites W1996795416 @default.
• W2096127904 cites W2001258296 @default.
• W2096127904 cites W2002153794 @default.
• W2096127904 cites W2009080022 @default.
• W2096127904 cites W2010069724 @default.
• W2096127904 cites W2018211174 @default.
• W2096127904 cites W2034269086 @default.
• W2096127904 cites W2035522058 @default.
• W2096127904 cites W2070093707 @default.
• W2096127904 cites W2076583198 @default.
• W2096127904 cites W2079226013 @default.
• W2096127904 cites W2079505803 @default.
• W2096127904 cites W2087884848 @default.
• W2096127904 cites W2088951849 @default.
• W2096127904 cites W2089923904 @default.
• W2096127904 cites W2091307724 @default.
• W2096127904 cites W2092279724 @default.
• W2096127904 cites W2096353669 @default.
• W2096127904 cites W2096820805 @default.
• W2096127904 cites W2102862792 @default.
• W2096127904 cites W2104574123 @default.
• W2096127904 cites W2104605495 @default.
• W2096127904 cites W2130858299 @default.
• W2096127904 cites W2149103230 @default.
• W2096127904 cites W2156161448 @default.
• W2096127904 cites W2237412095 @default.
• W2096127904 cites W2254038116 @default.
• W2096127904 cites W4255349690 @default.
• W2096127904 doi "https://doi.org/10.1242/jcs.01000" @default.
• W2096127904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14996910" @default.
• W2096127904 hasPublicationYear "2004" @default.
• W2096127904 type Work @default.
• W2096127904 sameAs 2096127904 @default.
• W2096127904 citedByCount "369" @default.
• W2096127904 countsByYear W20961279042012 @default.
• W2096127904 countsByYear W20961279042013 @default.
• W2096127904 countsByYear W20961279042014 @default.
• W2096127904 countsByYear W20961279042015 @default.
• W2096127904 countsByYear W20961279042016 @default.
• W2096127904 countsByYear W20961279042017 @default.
• W2096127904 countsByYear W20961279042018 @default.
• W2096127904 countsByYear W20961279042019 @default.
• W2096127904 countsByYear W20961279042020 @default.
• W2096127904 countsByYear W20961279042021 @default.
• W2096127904 countsByYear W20961279042022 @default.
• W2096127904 countsByYear W20961279042023 @default.
• W2096127904 crossrefType "journal-article" @default.
• W2096127904 hasAuthorship W2096127904A5012489838 @default.
• W2096127904 hasAuthorship W2096127904A5027267648 @default.
• W2096127904 hasAuthorship W2096127904A5041133587 @default.
• W2096127904 hasAuthorship W2096127904A5047592144 @default.
• W2096127904 hasAuthorship W2096127904A5083196258 @default.
• W2096127904 hasBestOaLocation W20961279041 @default.
• W2096127904 hasConcept C114246631 @default.
• W2096127904 hasConcept C121608353 @default.
• W2096127904 hasConcept C142724271 @default.
• W2096127904 hasConcept C203014093 @default.
• W2096127904 hasConcept C204232928 @default.
• W2096127904 hasConcept C2778001805 @default.
• W2096127904 hasConcept C2993273003 @default.
• W2096127904 hasConcept C502942594 @default.
• W2096127904 hasConcept C52124034 @default.
• W2096127904 hasConcept C529295009 @default.
• W2096127904 hasConcept C530470458 @default.
• W2096127904 hasConcept C54355233 @default.
• W2096127904 hasConcept C555283112 @default.
• W2096127904 hasConcept C71924100 @default.
• W2096127904 hasConcept C86803240 @default.
• W2096127904 hasConceptScore W2096127904C114246631 @default.
• W2096127904 hasConceptScore W2096127904C121608353 @default.
• W2096127904 hasConceptScore W2096127904C142724271 @default.
• W2096127904 hasConceptScore W2096127904C203014093 @default.
• W2096127904 hasConceptScore W2096127904C204232928 @default.
• W2096127904 hasConceptScore W2096127904C2778001805 @default.
• W2096127904 hasConceptScore W2096127904C2993273003 @default.
• W2096127904 hasConceptScore W2096127904C502942594 @default.
• W2096127904 hasConceptScore W2096127904C52124034 @default.
• W2096127904 hasConceptScore W2096127904C529295009 @default.
• W2096127904 hasConceptScore W2096127904C530470458 @default.
• W2096127904 hasConceptScore W2096127904C54355233 @default.
• W2096127904 hasConceptScore W2096127904C555283112 @default.
• W2096127904 hasConceptScore W2096127904C71924100 @default.
• W2096127904 hasConceptScore W2096127904C86803240 @default.

• next