Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096142952> ?p ?o ?g. }
- W2096142952 endingPage "e36024" @default.
- W2096142952 startingPage "e36024" @default.
- W2096142952 abstract "The apolipoprotein E4 (ApoE4) is an established risk factor for Alzheimer's disease (AD). Previous work has shown that this allele is associated with functional (fMRI) changes as well structural grey matter (GM) changes in healthy young, middle-aged and older subjects. Here, we assess the diffusion characteristics and the white matter (WM) tracts of healthy young (20-38 years) ApoE4 carriers and non-carriers. No significant differences in diffusion indices were found between young carriers (ApoE4+) and non-carriers (ApoE4-). There were also no significant differences between the groups in terms of normalised GM or WM volume. A feature selection algorithm (ReliefF) was used to select the most salient voxels from the diffusion data for subsequent classification with support vector machines (SVMs). SVMs were capable of classifying ApoE4 carrier and non-carrier groups with an extremely high level of accuracy. The top 500 voxels selected by ReliefF were then used as seeds for tractography which identified a WM network that included regions of the parietal lobe, the cingulum bundle and the dorsolateral frontal lobe. There was a non-significant decrease in volume of this WM network in the ApoE4 carrier group. Our results indicate that there are subtle WM differences between healthy young ApoE4 carriers and non-carriers and that the WM network identified may be particularly vulnerable to further degeneration in ApoE4 carriers as they enter middle and old age." @default.
- W2096142952 created "2016-06-24" @default.
- W2096142952 creator A5030802562 @default.
- W2096142952 creator A5031442012 @default.
- W2096142952 creator A5032426619 @default.
- W2096142952 creator A5037109052 @default.
- W2096142952 creator A5043595820 @default.
- W2096142952 creator A5054642286 @default.
- W2096142952 creator A5067078660 @default.
- W2096142952 creator A5070354760 @default.
- W2096142952 date "2012-04-25" @default.
- W2096142952 modified "2023-10-18" @default.
- W2096142952 title "White Matter Differences between Healthy Young ApoE4 Carriers and Non-Carriers Identified with Tractography and Support Vector Machines" @default.
- W2096142952 cites W140178960 @default.
- W2096142952 cites W1500895378 @default.
- W2096142952 cites W1545302199 @default.
- W2096142952 cites W1770880387 @default.
- W2096142952 cites W1823898 @default.
- W2096142952 cites W1944724818 @default.
- W2096142952 cites W1964940342 @default.
- W2096142952 cites W1968126294 @default.
- W2096142952 cites W1975921683 @default.
- W2096142952 cites W1980290744 @default.
- W2096142952 cites W1981000616 @default.
- W2096142952 cites W1986144956 @default.
- W2096142952 cites W1991732109 @default.
- W2096142952 cites W1995571867 @default.
- W2096142952 cites W1996433268 @default.
- W2096142952 cites W1997677703 @default.
- W2096142952 cites W1999670317 @default.
- W2096142952 cites W1999864873 @default.
- W2096142952 cites W2000133863 @default.
- W2096142952 cites W2002581945 @default.
- W2096142952 cites W2006233980 @default.
- W2096142952 cites W2017159332 @default.
- W2096142952 cites W2017456650 @default.
- W2096142952 cites W2018317330 @default.
- W2096142952 cites W2022207937 @default.
- W2096142952 cites W2022459144 @default.
- W2096142952 cites W2024289001 @default.
- W2096142952 cites W2028942474 @default.
- W2096142952 cites W2034968148 @default.
- W2096142952 cites W2036362108 @default.
- W2096142952 cites W2040178194 @default.
- W2096142952 cites W2040976452 @default.
- W2096142952 cites W2041325253 @default.
- W2096142952 cites W2044565580 @default.
- W2096142952 cites W2046557060 @default.
- W2096142952 cites W2048363354 @default.
- W2096142952 cites W2055522016 @default.
- W2096142952 cites W2060629467 @default.
- W2096142952 cites W2061195971 @default.
- W2096142952 cites W2063151296 @default.
- W2096142952 cites W2065166923 @default.
- W2096142952 cites W2066667961 @default.
- W2096142952 cites W2067179209 @default.
- W2096142952 cites W2067962939 @default.
- W2096142952 cites W2069014575 @default.
- W2096142952 cites W2071881327 @default.
- W2096142952 cites W2072220916 @default.
- W2096142952 cites W2072524743 @default.
- W2096142952 cites W2073589898 @default.
- W2096142952 cites W2078136810 @default.
- W2096142952 cites W2079428657 @default.
- W2096142952 cites W2079834962 @default.
- W2096142952 cites W2081825327 @default.
- W2096142952 cites W2088655169 @default.
- W2096142952 cites W2091287786 @default.
- W2096142952 cites W2098453896 @default.
- W2096142952 cites W2102496376 @default.
- W2096142952 cites W2102641992 @default.
- W2096142952 cites W2103717170 @default.
- W2096142952 cites W2104598584 @default.
- W2096142952 cites W2105843706 @default.
- W2096142952 cites W2107169104 @default.
- W2096142952 cites W2108027291 @default.
- W2096142952 cites W2110776675 @default.
- W2096142952 cites W2111813385 @default.
- W2096142952 cites W2113176889 @default.
- W2096142952 cites W2114300989 @default.
- W2096142952 cites W2126650951 @default.
- W2096142952 cites W2132091452 @default.
- W2096142952 cites W2135063296 @default.
- W2096142952 cites W2135893370 @default.
- W2096142952 cites W2136022845 @default.
- W2096142952 cites W2136573752 @default.
- W2096142952 cites W2138146838 @default.
- W2096142952 cites W2138790588 @default.
- W2096142952 cites W2139581313 @default.
- W2096142952 cites W2142059961 @default.
- W2096142952 cites W2148563522 @default.
- W2096142952 cites W2148726987 @default.
- W2096142952 cites W2150667092 @default.
- W2096142952 cites W2152021942 @default.
- W2096142952 cites W2163246541 @default.
- W2096142952 cites W2164303459 @default.
- W2096142952 cites W2166512828 @default.
- W2096142952 cites W2168247374 @default.