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- W2096152893 abstract "The earliest indication of developing folate deficiency in man occurs within 1 month of the onset of folate deprivation. It is a fall in the serum folate activity, as measured by microbiologic assay with L. casei. The next easily ascertainable sign occurs within the 2nd month: an increase in the average number of lobes of the nuclei of the neutrophilic polymorphonuclear leukocytes. After more than 3 months of folate deprivation, gross tissue depletion of folate becomes evident, as manifested by fall of L. casei-measurable erythrocyte and liver folate stores; rise in urinary excretion of formiminoglutamate (FIGLU), urocanate, formate, and aminoimidazolecarboxamide (AIC), and overt megaloblastic anemia." @default.
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- W2096152893 date "1967-06-01" @default.
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- W2096152893 title "Biochemical and Hematologic Lesions in Folic Acid Deficiency" @default.
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