FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096163622> ?p ?o ?g. }

• W2096163622 endingPage "1061" @default.
• W2096163622 startingPage "1052" @default.
• W2096163622 abstract "In the budding yeast Saccharomyces cerevisiae, four members of the importin-β family of nuclear carriers, Xpo1p/Crm1p, Cse1p, Msn5p and Los1p, function as exporters of protein and tRNA. Under normal growth conditions GFP-tagged exporters are predominantly associated with nuclei. The presence of Snf1 kinase, a key regulator of cell growth and a metabolic sensor, controls the localization of GFP-exporters. Additional glucose-dependent, but Snf1-independent, mechanisms regulate carrier distribution and a switch from fermentable to non-fermentable carbon sources relocates all of the carriers, suggesting a link to the nutritional status of the cell. Moreover, stress controls the proper localization of GFP-exporters, which mislocalize upon exposure to heat, ethanol and starvation. Stress may activate the MAPK cell integrity cascade, and we tested the role of this pathway in exporter localization. Under non-stress conditions, the proper distribution of GFP-Cse1p and Xpo1p/Crm1p-GFP requires kinases of the cell integrity cascade. By contrast, Msn5p-GFP and Los1p-GFP rely on the MAPK module to relocate to the cytoplasm when cells are stressed with ethanol. Our results indicate that the association of nuclear exporters with nuclei is controlled by multiple mechanisms that are organized in a hierarchical fashion and linked to the physiological state of the cell." @default.
• W2096163622 created "2016-06-24" @default.
• W2096163622 creator A5009049114 @default.
• W2096163622 creator A5033599840 @default.
• W2096163622 creator A5034299287 @default.
• W2096163622 creator A5077147763 @default.
• W2096163622 date "2007-07-01" @default.
• W2096163622 modified "2023-09-27" @default.
• W2096163622 title "The localization of nuclear exporters of the importin-β family is regulated by Snf1 kinase, nutrient supply and stress" @default.
• W2096163622 cites W1480534106 @default.
• W2096163622 cites W1484823281 @default.
• W2096163622 cites W1521764524 @default.
• W2096163622 cites W1599051410 @default.
• W2096163622 cites W1895267024 @default.
• W2096163622 cites W1971455959 @default.
• W2096163622 cites W1974538292 @default.
• W2096163622 cites W1977880141 @default.
• W2096163622 cites W1979870468 @default.
• W2096163622 cites W2004380965 @default.
• W2096163622 cites W2008100923 @default.
• W2096163622 cites W2022043674 @default.
• W2096163622 cites W2028193779 @default.
• W2096163622 cites W2044673780 @default.
• W2096163622 cites W2051440750 @default.
• W2096163622 cites W2058904982 @default.
• W2096163622 cites W2062692712 @default.
• W2096163622 cites W2063013559 @default.
• W2096163622 cites W2071982564 @default.
• W2096163622 cites W2075488235 @default.
• W2096163622 cites W2078724625 @default.
• W2096163622 cites W2095615304 @default.
• W2096163622 cites W2103081714 @default.
• W2096163622 cites W2103755904 @default.
• W2096163622 cites W2109913844 @default.
• W2096163622 cites W2112201668 @default.
• W2096163622 cites W2118260141 @default.
• W2096163622 cites W2120931117 @default.
• W2096163622 cites W2126431396 @default.
• W2096163622 cites W2134138119 @default.
• W2096163622 cites W2136623592 @default.
• W2096163622 cites W2143907477 @default.
• W2096163622 cites W2147594695 @default.
• W2096163622 cites W2155085170 @default.
• W2096163622 cites W2157937554 @default.
• W2096163622 doi "https://doi.org/10.1016/j.bbamcr.2007.04.014" @default.
• W2096163622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17544521" @default.
• W2096163622 hasPublicationYear "2007" @default.
• W2096163622 type Work @default.
• W2096163622 sameAs 2096163622 @default.
• W2096163622 citedByCount "24" @default.
• W2096163622 countsByYear W20961636222012 @default.
• W2096163622 countsByYear W20961636222013 @default.
• W2096163622 countsByYear W20961636222014 @default.
• W2096163622 countsByYear W20961636222015 @default.
• W2096163622 countsByYear W20961636222016 @default.
• W2096163622 countsByYear W20961636222018 @default.
• W2096163622 countsByYear W20961636222023 @default.
• W2096163622 crossrefType "journal-article" @default.
• W2096163622 hasAuthorship W2096163622A5009049114 @default.
• W2096163622 hasAuthorship W2096163622A5033599840 @default.
• W2096163622 hasAuthorship W2096163622A5034299287 @default.
• W2096163622 hasAuthorship W2096163622A5077147763 @default.
• W2096163622 hasConcept C104317684 @default.
• W2096163622 hasConcept C11960822 @default.
• W2096163622 hasConcept C133882971 @default.
• W2096163622 hasConcept C142613039 @default.
• W2096163622 hasConcept C184235292 @default.
• W2096163622 hasConcept C190062978 @default.
• W2096163622 hasConcept C2777576037 @default.
• W2096163622 hasConcept C2779222958 @default.
• W2096163622 hasConcept C2780114586 @default.
• W2096163622 hasConcept C29512474 @default.
• W2096163622 hasConcept C49805395 @default.
• W2096163622 hasConcept C54757728 @default.
• W2096163622 hasConcept C55493867 @default.
• W2096163622 hasConcept C59157529 @default.
• W2096163622 hasConcept C86339819 @default.
• W2096163622 hasConcept C86803240 @default.
• W2096163622 hasConcept C95444343 @default.
• W2096163622 hasConceptScore W2096163622C104317684 @default.
• W2096163622 hasConceptScore W2096163622C11960822 @default.
• W2096163622 hasConceptScore W2096163622C133882971 @default.
• W2096163622 hasConceptScore W2096163622C142613039 @default.
• W2096163622 hasConceptScore W2096163622C184235292 @default.
• W2096163622 hasConceptScore W2096163622C190062978 @default.
• W2096163622 hasConceptScore W2096163622C2777576037 @default.
• W2096163622 hasConceptScore W2096163622C2779222958 @default.
• W2096163622 hasConceptScore W2096163622C2780114586 @default.
• W2096163622 hasConceptScore W2096163622C29512474 @default.
• W2096163622 hasConceptScore W2096163622C49805395 @default.
• W2096163622 hasConceptScore W2096163622C54757728 @default.
• W2096163622 hasConceptScore W2096163622C55493867 @default.
• W2096163622 hasConceptScore W2096163622C59157529 @default.
• W2096163622 hasConceptScore W2096163622C86339819 @default.
• W2096163622 hasConceptScore W2096163622C86803240 @default.
• W2096163622 hasConceptScore W2096163622C95444343 @default.
• W2096163622 hasIssue "7" @default.
• W2096163622 hasLocation W20961636221 @default.

• next