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- W2096164927 endingPage "1036" @default.
- W2096164927 startingPage "1023" @default.
- W2096164927 abstract "The bacterium that causes tuberculosis, Mycobacterium tuberculosis, possesses a rather unique outer membrane composed largely of lipids that possess long-chain and branched fatty acids, called mycolic acids. These lipids form a permeability barrier that prevents entry of many environmental solutes, thereby making these bacteria acid-fast and able to survive extremely hostile surroundings. Antitubercular drugs must penetrate this layer to reach their target. This review highlights drug development efforts that have added to the slowly growing tuberculosis drug pipeline, identified new enzyme activities to target with drugs and increased the understanding of important biosynthetic pathways for mycobacterial outer membrane and cell wall core assembly. In addition, a portion of this review looks at discovery efforts aimed at weakening this barrier to decrease mycobacterial virulence, decrease fitness in the host or enhance the efficacy of the current drug repertoire by disrupting the permeability barrier." @default.
- W2096164927 created "2016-06-24" @default.
- W2096164927 creator A5051321476 @default.
- W2096164927 creator A5069193178 @default.
- W2096164927 date "2012-09-01" @default.
- W2096164927 modified "2023-10-16" @default.
- W2096164927 title "Targeting the mycobacterial envelope for tuberculosis drug development" @default.
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