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- W2096174086 abstract "A qualitative screening technique was developed for the detection of 2-amino-5-chloropyridine, a newly identified decomposition product of zopiclone and metabolites after alkaline hydrolysis of urine samples. The method was elaborated using a standard operation procedure (Merck Tox Screening System), combining a solid-phase extraction with reversed-phase high-performance liquid chromatography and diode array detection. The limit of detection, expressed as zopiclone concentrations in spiked urine, was found to be 0.5 µg/mL. Field urine samples from a volunteer were positive for 2-amino-5-chloropyridine until 16 h after ingestion of one therapeutic dose of Imovane (7.5 mg zopiclone)." @default.
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- W2096174086 date "1997-05-01" @default.
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- W2096174086 title "Detection of 2-Amino-5-Chloropyridine in Urine as a Parameter of Zopiclone (Imovane®) Intake using HPLC with Diode Array Detection" @default.
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- W2096174086 doi "https://doi.org/10.1093/jat/21.3.208" @default.
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