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- W2096176385 abstract "Proteins in the transforming growth factor-beta (TGF-beta) family recognize transmembrane serine/threonine kinases known as type I and type II receptors. Binding of TGF-beta to receptors results in receptor down-regulation and signaling. Whereas previous work has focused on activities controlling TGF-beta signaling, more recent studies have begun to address the trafficking properties of TGF-beta receptors. In this report, it is shown that receptors undergo recycling both in the presence and absence of ligand activation, with the rates of internalization and recycling being unaffected by ligand binding. Recycling occurs as receptors are most likely internalized through clathrin-coated pits, and then returned to the plasma membrane via a rab11-dependent, rab4-independent mechanism. Together, the results suggest a mechanism wherein activated TGF-beta receptors are directed to a distinct endocytic pathway for down-regulation and clathrin-dependent degradation after one or more rounds of recycling." @default.
- W2096176385 created "2016-06-24" @default.
- W2096176385 creator A5013289611 @default.
- W2096176385 creator A5059359203 @default.
- W2096176385 creator A5061514063 @default.
- W2096176385 creator A5073418646 @default.
- W2096176385 date "2004-09-01" @default.
- W2096176385 modified "2023-10-10" @default.
- W2096176385 title "Ligand-dependent and -independent Transforming Growth Factor-β Receptor Recycling Regulated by Clathrin-mediated Endocytosis and Rab11" @default.
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- W2096176385 doi "https://doi.org/10.1091/mbc.e04-03-0245" @default.
- W2096176385 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/515349" @default.
- W2096176385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15229286" @default.
- W2096176385 hasPublicationYear "2004" @default.
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