Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096177579> ?p ?o ?g. }
- W2096177579 endingPage "e7845" @default.
- W2096177579 startingPage "e7845" @default.
- W2096177579 abstract "Countries worldwide recommend women planning pregnancy to use daily 400 microg of synthetic folic acid in the periconceptional period to prevent birth defects in children. The underlying mechanisms of this preventive effect are not clear, however, epigenetic modulation of growth processes by folic acid is hypothesized. Here, we investigated whether periconceptional maternal folic acid use and markers of global DNA methylation potential (S-adenosylmethionine and S-adenosylhomocysteine blood levels) in mothers and children affect methylation of the insulin-like growth factor 2 gene differentially methylation region (IGF2 DMR) in the child. Moreover, we tested whether the methylation of the IGF2 DMR was independently associated with birth weight.IGF2 DMR methylation in 120 children aged 17 months (SD 0.3) of whom 86 mothers had used and 34 had not used folic acid periconceptionally were studied. Methylation was measured of 5 CpG dinucleotides covering the DMR using a mass spectrometry-based method. Children of mother who used folic acid had a 4.5% higher methylation of the IGF2 DMR than children who were not exposed to folic acid (49.5% vs. 47.4%; p = 0.014). IGF2 DMR methylation of the children also was associated with the S-adenosylmethionine blood level of the mother but not of the child (+1.7% methylation per SD S-adenosylmethionine; p = 0.037). Finally, we observed an inverse independent association between IGF2 DMR methylation and birth weight (-1.7% methylation per SD birthweight; p = 0.034).Periconceptional folic acid use is associated with epigenetic changes in IGF2 in the child that may affect intrauterine programming of growth and development with consequences for health and disease throughout life. These results indicate plasticity of IGF2 methylation by periconceptional folic acid use." @default.
- W2096177579 created "2016-06-24" @default.
- W2096177579 creator A5001839030 @default.
- W2096177579 creator A5007472849 @default.
- W2096177579 creator A5007540091 @default.
- W2096177579 creator A5037284171 @default.
- W2096177579 creator A5061790401 @default.
- W2096177579 creator A5071478025 @default.
- W2096177579 creator A5073064298 @default.
- W2096177579 creator A5075145005 @default.
- W2096177579 date "2009-11-16" @default.
- W2096177579 modified "2023-10-10" @default.
- W2096177579 title "Periconceptional Maternal Folic Acid Use of 400 µg per Day Is Related to Increased Methylation of the IGF2 Gene in the Very Young Child" @default.
- W2096177579 cites W1865687426 @default.
- W2096177579 cites W1922615383 @default.
- W2096177579 cites W1932296264 @default.
- W2096177579 cites W1967064280 @default.
- W2096177579 cites W1972824603 @default.
- W2096177579 cites W1976588842 @default.
- W2096177579 cites W1998970086 @default.
- W2096177579 cites W2002262392 @default.
- W2096177579 cites W2003946492 @default.
- W2096177579 cites W2012963160 @default.
- W2096177579 cites W2055358412 @default.
- W2096177579 cites W2056539393 @default.
- W2096177579 cites W2082254504 @default.
- W2096177579 cites W2083116612 @default.
- W2096177579 cites W2105686571 @default.
- W2096177579 cites W2114949397 @default.
- W2096177579 cites W2121099849 @default.
- W2096177579 cites W2123557252 @default.
- W2096177579 cites W2124870551 @default.
- W2096177579 cites W2136775778 @default.
- W2096177579 cites W2140418591 @default.
- W2096177579 cites W2143858605 @default.
- W2096177579 cites W2151351671 @default.
- W2096177579 cites W2158384762 @default.
- W2096177579 cites W2158669467 @default.
- W2096177579 cites W2159409293 @default.
- W2096177579 cites W2286141548 @default.
- W2096177579 cites W4251721728 @default.
- W2096177579 doi "https://doi.org/10.1371/journal.pone.0007845" @default.
- W2096177579 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2773848" @default.
- W2096177579 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19924280" @default.
- W2096177579 hasPublicationYear "2009" @default.
- W2096177579 type Work @default.
- W2096177579 sameAs 2096177579 @default.
- W2096177579 citedByCount "421" @default.
- W2096177579 countsByYear W20961775792012 @default.
- W2096177579 countsByYear W20961775792013 @default.
- W2096177579 countsByYear W20961775792014 @default.
- W2096177579 countsByYear W20961775792015 @default.
- W2096177579 countsByYear W20961775792016 @default.
- W2096177579 countsByYear W20961775792017 @default.
- W2096177579 countsByYear W20961775792018 @default.
- W2096177579 countsByYear W20961775792019 @default.
- W2096177579 countsByYear W20961775792020 @default.
- W2096177579 countsByYear W20961775792021 @default.
- W2096177579 countsByYear W20961775792022 @default.
- W2096177579 countsByYear W20961775792023 @default.
- W2096177579 crossrefType "journal-article" @default.
- W2096177579 hasAuthorship W2096177579A5001839030 @default.
- W2096177579 hasAuthorship W2096177579A5007472849 @default.
- W2096177579 hasAuthorship W2096177579A5007540091 @default.
- W2096177579 hasAuthorship W2096177579A5037284171 @default.
- W2096177579 hasAuthorship W2096177579A5061790401 @default.
- W2096177579 hasAuthorship W2096177579A5071478025 @default.
- W2096177579 hasAuthorship W2096177579A5073064298 @default.
- W2096177579 hasAuthorship W2096177579A5075145005 @default.
- W2096177579 hasBestOaLocation W20961775791 @default.
- W2096177579 hasConcept C104317684 @default.
- W2096177579 hasConcept C126322002 @default.
- W2096177579 hasConcept C134018914 @default.
- W2096177579 hasConcept C140173407 @default.
- W2096177579 hasConcept C150194340 @default.
- W2096177579 hasConcept C190727270 @default.
- W2096177579 hasConcept C2779234561 @default.
- W2096177579 hasConcept C33288867 @default.
- W2096177579 hasConcept C41091548 @default.
- W2096177579 hasConcept C54355233 @default.
- W2096177579 hasConcept C66322754 @default.
- W2096177579 hasConcept C71924100 @default.
- W2096177579 hasConcept C86803240 @default.
- W2096177579 hasConceptScore W2096177579C104317684 @default.
- W2096177579 hasConceptScore W2096177579C126322002 @default.
- W2096177579 hasConceptScore W2096177579C134018914 @default.
- W2096177579 hasConceptScore W2096177579C140173407 @default.
- W2096177579 hasConceptScore W2096177579C150194340 @default.
- W2096177579 hasConceptScore W2096177579C190727270 @default.
- W2096177579 hasConceptScore W2096177579C2779234561 @default.
- W2096177579 hasConceptScore W2096177579C33288867 @default.
- W2096177579 hasConceptScore W2096177579C41091548 @default.
- W2096177579 hasConceptScore W2096177579C54355233 @default.
- W2096177579 hasConceptScore W2096177579C66322754 @default.
- W2096177579 hasConceptScore W2096177579C71924100 @default.
- W2096177579 hasConceptScore W2096177579C86803240 @default.
- W2096177579 hasIssue "11" @default.
- W2096177579 hasLocation W20961775791 @default.