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- W2096197732 abstract "Our primary objective was to investigate a biomarker driven model for the interrelationships between vascular disease pathology, amyloid pathology, and longitudinal cognitive decline in cognitively normal elderly subjects between 70 and 90 years of age. Our secondary objective was to investigate the beneficial effect of cognitive reserve on these interrelationships. We used brain amyloid-β load measured using Pittsburgh compound B positron emission tomography as a marker for amyloid pathology. White matter hyperintensities and brain infarcts were measured using fluid-attenuated inversion recovery magnetic resonance imaging as a marker for vascular pathology. We studied 393 cognitively normal elderly participants in the population-based Mayo Clinic Study of Aging who had a baseline 3 T fluid-attenuated inversion recovery magnetic resonance imaging assessment, Pittsburgh compound B positron emission tomography scan, baseline cognitive assessment, lifestyle measures, and at least one additional clinical follow-up. We classified subjects as being on the amyloid pathway if they had a global cortical amyloid-β load of ≥1.5 standard uptake value ratio and those on the vascular pathway if they had a brain infarct and/or white matter hyperintensities load ≥1.11% of total intracranial volume (which corresponds to the top 25% of white matter hyperintensities in an independent non-demented sample). We used a global cognitive z-score as a measure of cognition. We found no evidence that the presence or absence of vascular pathology influenced the presence or absence of amyloid pathology and vice versa, suggesting that the two processes seem to be independent. Baseline cognitive performance was lower in older individuals, in males, those with lower education/occupation, and those on the amyloid pathway. The rate of cognitive decline was higher in older individuals (P < 0.001) and those with amyloid (P = 0.0003) or vascular (P = 0.0037) pathologies. In those subjects with both vascular and amyloid pathologies, the effect of both pathologies on cognition was additive and not synergistic. For a 79-year-old subject, the predicted annual rate of global z-score decline was -0.02 if on neither pathway, -0.07 if on the vascular pathway, -0.08 if on the amyloid pathway and -0.13 if on both pathways. The main conclusions of this study were: (i) amyloid and vascular pathologies seem to be at least partly independent processes that both affect longitudinal cognitive trajectories adversely and are major drivers of cognitive decline in the elderly; and (ii) cognitive reserve seems to offset the deleterious effect of both pathologies on the cognitive trajectories." @default.
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- W2096197732 date "2015-01-13" @default.
- W2096197732 modified "2023-10-12" @default.
- W2096197732 title "Vascular and amyloid pathologies are independent predictors of cognitive decline in normal elderly" @default.
- W2096197732 cites W1489506413 @default.
- W2096197732 cites W1490420159 @default.
- W2096197732 cites W1526046891 @default.
- W2096197732 cites W1548995643 @default.
- W2096197732 cites W1562031459 @default.
- W2096197732 cites W1598543349 @default.
- W2096197732 cites W182422435 @default.
- W2096197732 cites W1837941181 @default.
- W2096197732 cites W1892764900 @default.
- W2096197732 cites W1963568158 @default.
- W2096197732 cites W1963973361 @default.
- W2096197732 cites W1970353438 @default.
- W2096197732 cites W1971459541 @default.
- W2096197732 cites W1972661606 @default.
- W2096197732 cites W1973159346 @default.
- W2096197732 cites W1974934145 @default.
- W2096197732 cites W1984009511 @default.
- W2096197732 cites W1987473536 @default.
- W2096197732 cites W1993571512 @default.
- W2096197732 cites W1995306982 @default.
- W2096197732 cites W1999367055 @default.
- W2096197732 cites W2000291174 @default.
- W2096197732 cites W2001851338 @default.
- W2096197732 cites W2007709223 @default.
- W2096197732 cites W2008762660 @default.
- W2096197732 cites W2013200926 @default.
- W2096197732 cites W2014940057 @default.
- W2096197732 cites W2015580059 @default.
- W2096197732 cites W2018254986 @default.
- W2096197732 cites W2020780341 @default.
- W2096197732 cites W2023420093 @default.
- W2096197732 cites W2023649381 @default.
- W2096197732 cites W2025774809 @default.
- W2096197732 cites W2031061595 @default.
- W2096197732 cites W2033085283 @default.
- W2096197732 cites W2045794894 @default.
- W2096197732 cites W2048147200 @default.
- W2096197732 cites W2053395355 @default.
- W2096197732 cites W2055568131 @default.
- W2096197732 cites W2059481988 @default.
- W2096197732 cites W2065012668 @default.
- W2096197732 cites W2065338300 @default.
- W2096197732 cites W2070054259 @default.
- W2096197732 cites W2074249519 @default.
- W2096197732 cites W2075105932 @default.
- W2096197732 cites W2076929722 @default.
- W2096197732 cites W2077033394 @default.
- W2096197732 cites W2079872795 @default.
- W2096197732 cites W2084484659 @default.
- W2096197732 cites W2089203471 @default.
- W2096197732 cites W2091265793 @default.
- W2096197732 cites W2091515151 @default.
- W2096197732 cites W2092932101 @default.
- W2096197732 cites W2099797739 @default.
- W2096197732 cites W2106643009 @default.
- W2096197732 cites W2108293654 @default.
- W2096197732 cites W2110703451 @default.
- W2096197732 cites W2111399612 @default.
- W2096197732 cites W2116709840 @default.
- W2096197732 cites W2118521681 @default.
- W2096197732 cites W2120441632 @default.
- W2096197732 cites W2128307173 @default.
- W2096197732 cites W2137389079 @default.
- W2096197732 cites W2137665441 @default.
- W2096197732 cites W2146343703 @default.
- W2096197732 cites W2148079076 @default.
- W2096197732 cites W2153986904 @default.
- W2096197732 cites W2155893481 @default.
- W2096197732 cites W2157868610 @default.
- W2096197732 cites W2161962285 @default.
- W2096197732 cites W2162258689 @default.
- W2096197732 cites W2163718643 @default.
- W2096197732 cites W2171702345 @default.
- W2096197732 cites W4241388204 @default.
- W2096197732 cites W4296588155 @default.
- W2096197732 doi "https://doi.org/10.1093/brain/awu393" @default.
- W2096197732 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4339775" @default.