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• W2096202010 abstract "<h3>Context</h3> Although anxiety disorders are heritable, their genetic and phenotypic complexity has made the identification of susceptibility genes difficult. Well-validated animal models and intermediate phenotypes provide crucial tools for genetic dissection of anxiety. The gene encoding regulator of G protein signaling 2 (<i>Rgs2</i>) is a quantitative trait gene that influences mouse anxiety behavior, making its human ortholog (<i>RGS2</i>) a compelling candidate gene for human anxiety phenotypes. <h3>Objective</h3> To examine whether variation in<i>RGS2</i>is associated with intermediate phenotypes for human anxiety disorders. <h3>Design</h3> Family-based and case-control association analysis of single-nucleotide polymorphisms at the<i>RGS2</i>locus in 3 independent samples. <h3>Setting</h3> Massachusetts General Hospital, University of California, San Diego, and San Diego State University. <h3>Participants</h3> Study participants included a family-based sample (n = 119 families) of children who underwent laboratory-based assessments of temperament (behavioral inhibition), a sample of 744 unrelated adults who completed assessments of extraversion and introversion, and 55 unrelated adults who underwent functional magnetic resonance imaging measures of response to emotional faces. <h3>Main Outcome Measures</h3> Laboratory-based behavioral measures of childhood temperament, self-report measure of personality, and functional magnetic resonance imaging response to emotion processing. <h3>Results</h3> Markers spanning<i>RGS2</i>were associated with childhood behavioral inhibition, a temperamental precursor of social anxiety disorder (haplotype<i>P</i> = 3 × 10⁻⁵; odds ratio, 2.99 in complete trios). In independent samples,<i>RGS2</i>markers, including rs4606, which has previously been associated with<i>RGS2</i>expression, were also associated with introversion (a core personality trait in social anxiety disorder) and with increased limbic activation (insular cortex and amygdala) during emotion processing (brain phenotypes correlated with social anxiety). The genotype at rs4606 explained 10% to 15% of the variance in amygdala and insular cortex activation to emotional faces. <h3>Conclusions</h3> These results provide the first evidence that a gene that influences anxiety in mice is associated with intermediate phenotypes for human anxiety disorders across multiple levels of assessment, including childhood temperament, adult personality, and brain function. This translational research suggests that some genetic influences on anxiety are evolutionarily conserved and that pharmacologic modulation of<i>RGS2</i>function may provide a novel therapeutic approach for anxiety disorders." @default.
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• W2096202010 date "2008-03-01" @default.
• W2096202010 modified "2023-10-16" @default.
• W2096202010 title "Influence of RGS2 on Anxiety-Related Temperament, Personality, and Brain Function" @default.
• W2096202010 cites W133799122 @default.
• W2096202010 cites W1965689961 @default.
• W2096202010 cites W1985318959 @default.
• W2096202010 cites W1985778833 @default.
• W2096202010 cites W1986066265 @default.
• W2096202010 cites W1986986810 @default.
• W2096202010 cites W1988105356 @default.
• W2096202010 cites W1988557303 @default.
• W2096202010 cites W1994479132 @default.
• W2096202010 cites W1998154806 @default.
• W2096202010 cites W2007521027 @default.
• W2096202010 cites W2010612795 @default.
• W2096202010 cites W2012078677 @default.
• W2096202010 cites W2012845097 @default.
• W2096202010 cites W2014790948 @default.
• W2096202010 cites W2016572676 @default.
• W2096202010 cites W2017156180 @default.
• W2096202010 cites W2018483093 @default.
• W2096202010 cites W2033400593 @default.
• W2096202010 cites W2042048325 @default.
• W2096202010 cites W2046288371 @default.
• W2096202010 cites W2052021493 @default.
• W2096202010 cites W2055110493 @default.
• W2096202010 cites W2063349862 @default.
• W2096202010 cites W2065650437 @default.
• W2096202010 cites W2073093865 @default.
• W2096202010 cites W2075273444 @default.
• W2096202010 cites W2079459508 @default.
• W2096202010 cites W2081281959 @default.
• W2096202010 cites W2087502638 @default.
• W2096202010 cites W2093396350 @default.
• W2096202010 cites W2103345644 @default.
• W2096202010 cites W2107164330 @default.
• W2096202010 cites W2112011572 @default.
• W2096202010 cites W2113395651 @default.
• W2096202010 cites W2117140276 @default.
• W2096202010 cites W2118136004 @default.
• W2096202010 cites W2118753748 @default.
• W2096202010 cites W2123432920 @default.
• W2096202010 cites W2124368930 @default.
• W2096202010 cites W2133318750 @default.
• W2096202010 cites W2136257668 @default.
• W2096202010 cites W2136972830 @default.
• W2096202010 cites W2137811349 @default.
• W2096202010 cites W2139722622 @default.
• W2096202010 cites W2143166807 @default.
• W2096202010 cites W2144325046 @default.
• W2096202010 cites W2147351252 @default.
• W2096202010 cites W2147938842 @default.
• W2096202010 cites W2150942434 @default.
• W2096202010 cites W2151811639 @default.
• W2096202010 cites W2156743186 @default.
• W2096202010 cites W2159975710 @default.
• W2096202010 cites W2161177515 @default.
• W2096202010 cites W2162044949 @default.
• W2096202010 cites W2164689073 @default.
• W2096202010 cites W2169366712 @default.
• W2096202010 cites W2980097029 @default.
• W2096202010 doi "https://doi.org/10.1001/archgenpsychiatry.2007.48" @default.
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