Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096251426> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2096251426 endingPage "953" @default.
- W2096251426 startingPage "945" @default.
- W2096251426 abstract "Abdominal aortic coarctation above the renal arteries leads to severe hypertension above the stenotic site and provides a model for simultaneous testing of the effects of increased and decreased pressure and consequently shear stress in the same animal. The effects of increased pressure, per se, on oxidative stress and antioxidant enzyme expression is unknown. We studied the protein expressions of antioxidant enzymes and NADPH oxidase (gp91phox subunit) in the aortic segments above and below the stenosis site in sham-operated control and aortic-banded rats at four weeks postoperatively. Compared with the control group, the banded group showed significant up-regulation of NADPH oxidase, catalase (CAT), Cu/Zn superoxide dismutase (SOD) and Mn SOD protein content in the thoracic aorta. In contrast, Mn SOD, Cu/Zn SOD and NADPH oxidase protein abundance were unchanged in the abdominal aortic segment below the stricture where blood pressure is not elevated, whereas CAT protein abundance was also elevated in the abdominal aorta. No changes were noted for glutathione peroxidase (GPX) protein content either in the thoracic or abdominal aortic segments. Coarctation-induced hypertension is associated with increased aortic CAT, Cu/Zn SOD, Mn SOD and NADPH oxidase protein expression. The up-regulation of NADPH oxidase increases reactive oxygen species (ROS) generation noted in the present study and contributes to inactivation of nitric oxide (NO) as shown previously in this model. Upregulation of antioxidant enzymes may be a compensatory response in the face of elevated pressure and oxidative stress. The normality of protein abundance in the abdominal aorta wherein blood pressure is not elevated points to the role of baromechanical factors, as opposed to circulating humoral factors that were similar in both segments, as a mechanism responsible for increased antioxidant enzyme expression." @default.
- W2096251426 created "2016-06-24" @default.
- W2096251426 creator A5002314385 @default.
- W2096251426 creator A5018333912 @default.
- W2096251426 creator A5037378495 @default.
- W2096251426 creator A5056238061 @default.
- W2096251426 creator A5088699403 @default.
- W2096251426 date "2005-01-01" @default.
- W2096251426 modified "2023-10-10" @default.
- W2096251426 title "Effects of aortic coarctation on aortic antioxidant enzymes and NADPH oxidase protein expression" @default.
- W2096251426 cites W1963799565 @default.
- W2096251426 cites W1976555160 @default.
- W2096251426 cites W1981918290 @default.
- W2096251426 cites W1996976658 @default.
- W2096251426 cites W2009771629 @default.
- W2096251426 cites W2037124575 @default.
- W2096251426 cites W2055348133 @default.
- W2096251426 cites W2062386281 @default.
- W2096251426 cites W2076977434 @default.
- W2096251426 cites W2085847434 @default.
- W2096251426 cites W2094201582 @default.
- W2096251426 cites W2101264433 @default.
- W2096251426 cites W2108791332 @default.
- W2096251426 cites W2110827050 @default.
- W2096251426 cites W2112336057 @default.
- W2096251426 cites W2121498680 @default.
- W2096251426 cites W2125823894 @default.
- W2096251426 cites W2126085531 @default.
- W2096251426 cites W2149429779 @default.
- W2096251426 cites W2159172002 @default.
- W2096251426 cites W2162639891 @default.
- W2096251426 cites W2169302466 @default.
- W2096251426 cites W2202081876 @default.
- W2096251426 cites W2262423141 @default.
- W2096251426 doi "https://doi.org/10.1016/j.lfs.2004.10.014" @default.
- W2096251426 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15589970" @default.
- W2096251426 hasPublicationYear "2005" @default.
- W2096251426 type Work @default.
- W2096251426 sameAs 2096251426 @default.
- W2096251426 citedByCount "44" @default.
- W2096251426 countsByYear W20962514262012 @default.
- W2096251426 countsByYear W20962514262013 @default.
- W2096251426 countsByYear W20962514262014 @default.
- W2096251426 countsByYear W20962514262018 @default.
- W2096251426 countsByYear W20962514262019 @default.
- W2096251426 crossrefType "journal-article" @default.
- W2096251426 hasAuthorship W2096251426A5002314385 @default.
- W2096251426 hasAuthorship W2096251426A5018333912 @default.
- W2096251426 hasAuthorship W2096251426A5037378495 @default.
- W2096251426 hasAuthorship W2096251426A5056238061 @default.
- W2096251426 hasAuthorship W2096251426A5088699403 @default.
- W2096251426 hasConcept C126322002 @default.
- W2096251426 hasConcept C134018914 @default.
- W2096251426 hasConcept C185592680 @default.
- W2096251426 hasConcept C2775838275 @default.
- W2096251426 hasConcept C2776151105 @default.
- W2096251426 hasConcept C2778004101 @default.
- W2096251426 hasConcept C2778979269 @default.
- W2096251426 hasConcept C2779719074 @default.
- W2096251426 hasConcept C48349386 @default.
- W2096251426 hasConcept C55493867 @default.
- W2096251426 hasConcept C71924100 @default.
- W2096251426 hasConceptScore W2096251426C126322002 @default.
- W2096251426 hasConceptScore W2096251426C134018914 @default.
- W2096251426 hasConceptScore W2096251426C185592680 @default.
- W2096251426 hasConceptScore W2096251426C2775838275 @default.
- W2096251426 hasConceptScore W2096251426C2776151105 @default.
- W2096251426 hasConceptScore W2096251426C2778004101 @default.
- W2096251426 hasConceptScore W2096251426C2778979269 @default.
- W2096251426 hasConceptScore W2096251426C2779719074 @default.
- W2096251426 hasConceptScore W2096251426C48349386 @default.
- W2096251426 hasConceptScore W2096251426C55493867 @default.
- W2096251426 hasConceptScore W2096251426C71924100 @default.
- W2096251426 hasIssue "8" @default.
- W2096251426 hasLocation W20962514261 @default.
- W2096251426 hasLocation W20962514262 @default.
- W2096251426 hasOpenAccess W2096251426 @default.
- W2096251426 hasPrimaryLocation W20962514261 @default.
- W2096251426 hasRelatedWork W1953847668 @default.
- W2096251426 hasRelatedWork W2025687052 @default.
- W2096251426 hasRelatedWork W2074324989 @default.
- W2096251426 hasRelatedWork W2081917043 @default.
- W2096251426 hasRelatedWork W2241760478 @default.
- W2096251426 hasRelatedWork W2329428880 @default.
- W2096251426 hasRelatedWork W3157404951 @default.
- W2096251426 hasRelatedWork W4367053317 @default.
- W2096251426 hasRelatedWork W3031685627 @default.
- W2096251426 hasRelatedWork W3091876869 @default.
- W2096251426 hasVolume "76" @default.
- W2096251426 isParatext "false" @default.
- W2096251426 isRetracted "false" @default.
- W2096251426 magId "2096251426" @default.
- W2096251426 workType "article" @default.