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• W2096274947 startingPage "3894" @default.
• W2096274947 abstract "The Mrc1 and Tof1 proteins are conserved throughout evolution, and in budding yeast they are known to associate with the MCM helicase and regulate the progression of DNA replication forks. Previous work has shown that Mrc1 is important for the activation of checkpoint kinases in responses to defects in S phase, but both Mrc1 and Tof1 also regulate the normal process of chromosome replication. Here, we show that these two important factors control the normal progression of DNA replication forks in distinct ways. The rate of progression of DNA replication forks is greatly reduced in the absence of Mrc1 but much less affected by loss of Tof1. In contrast, Tof1 is critical for DNA replication forks to pause at diverse chromosomal sites where nonnucleosomal proteins bind very tightly to DNA, and this role is not shared with Mrc1." @default.
• W2096274947 created "2016-06-24" @default.
• W2096274947 creator A5059339830 @default.
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• W2096274947 date "2007-10-01" @default.
• W2096274947 modified "2023-10-14" @default.
• W2096274947 title "Mrc1 and Tof1 Regulate DNA Replication Forks in Different Ways during Normal S Phase" @default.
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• W2096274947 doi "https://doi.org/10.1091/mbc.e07-05-0500" @default.
• W2096274947 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1995724" @default.
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• W2096274947 hasPublicationYear "2007" @default.
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