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- W2096277352 abstract "Abstract Human T-cell leukemia virus type-1 (HTLV-1) is associated with adult T-cell leukemia (ATL) and neurological syndromes. HTLV-1 encodes the oncoprotein Tax-1, which modulates viral and cellular gene expression leading to T-cell transformation. Guanine nucleotide–binding proteins (G proteins) and G protein–coupled receptors (GPCRs) constitute the largest family of membrane proteins known and are involved in the regulation of most biological functions. Here, we report an interaction between HTLV-1 Tax oncoprotein and the G-protein β subunit. Interestingly, though the G-protein β subunit inhibits Tax-mediated viral transcription, Tax-1 perturbs G-protein β subcellular localization. Functional evidence for these observations was obtained using conditional Tax-1–expressing transformed T-lymphocytes, where Tax expression correlated with activation of the SDF-1/CXCR4 axis. Our data indicated that HTLV-1 developed a strategy based on the activation of the SDF-1/CXCR4 axis in the infected cell; this could have tremendous implications for new therapeutic strategies." @default.
- W2096277352 created "2016-06-24" @default.
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- W2096277352 date "2006-09-21" @default.
- W2096277352 modified "2023-10-18" @default.
- W2096277352 title "Human T-cell leukemia virus type-1 Tax oncoprotein regulates G-protein signaling" @default.
- W2096277352 cites W1517501247 @default.
- W2096277352 cites W1520928812 @default.
- W2096277352 cites W1539291165 @default.
- W2096277352 cites W1559919026 @default.
- W2096277352 cites W1565609887 @default.
- W2096277352 cites W1963533186 @default.
- W2096277352 cites W1967946797 @default.
- W2096277352 cites W1967960991 @default.
- W2096277352 cites W1971732967 @default.
- W2096277352 cites W1974015349 @default.
- W2096277352 cites W1979947787 @default.
- W2096277352 cites W1989035987 @default.
- W2096277352 cites W1995664935 @default.
- W2096277352 cites W1996166884 @default.
- W2096277352 cites W1996726668 @default.
- W2096277352 cites W1997523018 @default.
- W2096277352 cites W1998461588 @default.
- W2096277352 cites W2004827589 @default.
- W2096277352 cites W2021951468 @default.
- W2096277352 cites W2022142379 @default.
- W2096277352 cites W2023649595 @default.
- W2096277352 cites W2025721662 @default.
- W2096277352 cites W2025959287 @default.
- W2096277352 cites W2030185192 @default.
- W2096277352 cites W2031488553 @default.
- W2096277352 cites W2036789689 @default.
- W2096277352 cites W2039426604 @default.
- W2096277352 cites W2040122866 @default.
- W2096277352 cites W2041984212 @default.
- W2096277352 cites W2049768914 @default.
- W2096277352 cites W2061701339 @default.
- W2096277352 cites W2066109743 @default.
- W2096277352 cites W2068292485 @default.
- W2096277352 cites W2069667541 @default.
- W2096277352 cites W2069729178 @default.
- W2096277352 cites W2071129811 @default.
- W2096277352 cites W2074091309 @default.
- W2096277352 cites W2076256408 @default.
- W2096277352 cites W2079833232 @default.
- W2096277352 cites W2079929369 @default.
- W2096277352 cites W2085668133 @default.
- W2096277352 cites W2086143621 @default.
- W2096277352 cites W2088759160 @default.
- W2096277352 cites W2093184710 @default.
- W2096277352 cites W2095769092 @default.
- W2096277352 cites W2100623645 @default.
- W2096277352 cites W2102867972 @default.
- W2096277352 cites W2107409794 @default.
- W2096277352 cites W2107927368 @default.
- W2096277352 cites W2107949774 @default.
- W2096277352 cites W2107966497 @default.
- W2096277352 cites W2110220145 @default.
- W2096277352 cites W2113391491 @default.
- W2096277352 cites W2115851778 @default.
- W2096277352 cites W2123304597 @default.
- W2096277352 cites W2124135408 @default.
- W2096277352 cites W2124140485 @default.
- W2096277352 cites W2125853173 @default.
- W2096277352 cites W2130704169 @default.
- W2096277352 cites W2134057315 @default.
- W2096277352 cites W2134594325 @default.
- W2096277352 cites W2139129258 @default.
- W2096277352 cites W2143901273 @default.
- W2096277352 cites W2144192014 @default.
- W2096277352 cites W2145827111 @default.
- W2096277352 cites W2145861891 @default.
- W2096277352 cites W2148963137 @default.
- W2096277352 cites W2149138755 @default.
- W2096277352 cites W2152922534 @default.
- W2096277352 cites W2159120707 @default.
- W2096277352 cites W2159220982 @default.
- W2096277352 cites W2160577864 @default.
- W2096277352 cites W2161733460 @default.
- W2096277352 cites W2164810650 @default.
- W2096277352 cites W2168774029 @default.
- W2096277352 cites W2168808956 @default.
- W2096277352 cites W2339809048 @default.
- W2096277352 cites W2428440012 @default.