Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096277721> ?p ?o ?g. }
- W2096277721 endingPage "486" @default.
- W2096277721 startingPage "469" @default.
- W2096277721 abstract "ABSTRACT Chromosomes from the fission yeast Schizosaccharomyces pombe have been introduced into mouse cells by protoplast fusion. In most cell lines the yeast DNA integrates into a single site within a mouse chromosome and results in striking chromosome morphology at metaphase. Both light and electron microscopy show that the yeast chromosome region is narrower than the flanking mouse DNA. Regions of the yeast insert stain less intensely with propidium iodide than surrounding DNA and bear a morphological resemblance to fragile sites. We investigate the composition of the yeast transgenomes and the modification and chromatin structure of this yeast DNA in mouse cells. We suggest that the underlying basis for the structure we see lies above the level of DNA modification and nucleosome assembly, and may reflect the attachment of the yeast DNA to the rodent cell nucleoskeleton. The yeast integrant replicates late in S phase at a time when G bands of the mouse chromosomes are being replicated, and participates in sister chromatid exchanges at a high frequency. We discuss the implications of these studies to the understanding of how chromatin folding relates to metaphase chromosome morphology and how large stretches of foreign DNA behave when introduced into mammalian cells." @default.
- W2096277721 created "2016-06-24" @default.
- W2096277721 creator A5015101570 @default.
- W2096277721 creator A5037988172 @default.
- W2096277721 creator A5050013797 @default.
- W2096277721 creator A5050574230 @default.
- W2096277721 creator A5051309547 @default.
- W2096277721 creator A5059165738 @default.
- W2096277721 creator A5076700359 @default.
- W2096277721 creator A5083046212 @default.
- W2096277721 date "1994-03-01" @default.
- W2096277721 modified "2023-09-23" @default.
- W2096277721 title "Unusual chromosome structure of fission yeast DNA in mouse cells" @default.
- W2096277721 cites W1006291621 @default.
- W2096277721 cites W1505536714 @default.
- W2096277721 cites W1572269097 @default.
- W2096277721 cites W1874943101 @default.
- W2096277721 cites W1963653582 @default.
- W2096277721 cites W1966226316 @default.
- W2096277721 cites W1968472660 @default.
- W2096277721 cites W1977401027 @default.
- W2096277721 cites W1978143896 @default.
- W2096277721 cites W1979524912 @default.
- W2096277721 cites W1985048877 @default.
- W2096277721 cites W1986949014 @default.
- W2096277721 cites W1989128125 @default.
- W2096277721 cites W1990494717 @default.
- W2096277721 cites W1993969806 @default.
- W2096277721 cites W1998372019 @default.
- W2096277721 cites W1999861460 @default.
- W2096277721 cites W2000974408 @default.
- W2096277721 cites W2001504724 @default.
- W2096277721 cites W2001895759 @default.
- W2096277721 cites W2001995677 @default.
- W2096277721 cites W2002635441 @default.
- W2096277721 cites W2003279154 @default.
- W2096277721 cites W2003946096 @default.
- W2096277721 cites W2005438757 @default.
- W2096277721 cites W2006984368 @default.
- W2096277721 cites W2019068828 @default.
- W2096277721 cites W2019098558 @default.
- W2096277721 cites W2024799182 @default.
- W2096277721 cites W2024938036 @default.
- W2096277721 cites W2026111974 @default.
- W2096277721 cites W2029234227 @default.
- W2096277721 cites W2029353257 @default.
- W2096277721 cites W2033501768 @default.
- W2096277721 cites W2034694342 @default.
- W2096277721 cites W2035358971 @default.
- W2096277721 cites W2036339125 @default.
- W2096277721 cites W2051902571 @default.
- W2096277721 cites W2062715663 @default.
- W2096277721 cites W2063206503 @default.
- W2096277721 cites W2069559082 @default.
- W2096277721 cites W2069600152 @default.
- W2096277721 cites W2069644796 @default.
- W2096277721 cites W2069917420 @default.
- W2096277721 cites W2077362267 @default.
- W2096277721 cites W2079255836 @default.
- W2096277721 cites W2079375464 @default.
- W2096277721 cites W2080391159 @default.
- W2096277721 cites W2083252398 @default.
- W2096277721 cites W2085458595 @default.
- W2096277721 cites W2089768151 @default.
- W2096277721 cites W2091666349 @default.
- W2096277721 cites W2095256418 @default.
- W2096277721 cites W2100475900 @default.
- W2096277721 cites W2101588034 @default.
- W2096277721 cites W2110596072 @default.
- W2096277721 cites W2120772790 @default.
- W2096277721 cites W212138329 @default.
- W2096277721 cites W2138576404 @default.
- W2096277721 cites W2167855529 @default.
- W2096277721 cites W2194986544 @default.
- W2096277721 cites W2313143772 @default.
- W2096277721 cites W337568220 @default.
- W2096277721 cites W4211087645 @default.
- W2096277721 cites W4237467716 @default.
- W2096277721 cites W4253129203 @default.
- W2096277721 cites W4379409659 @default.
- W2096277721 cites W55548661 @default.
- W2096277721 doi "https://doi.org/10.1242/jcs.107.3.469" @default.
- W2096277721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8006067" @default.
- W2096277721 hasPublicationYear "1994" @default.
- W2096277721 type Work @default.
- W2096277721 sameAs 2096277721 @default.
- W2096277721 citedByCount "31" @default.
- W2096277721 countsByYear W20962777212013 @default.
- W2096277721 countsByYear W20962777212014 @default.
- W2096277721 countsByYear W20962777212015 @default.
- W2096277721 countsByYear W20962777212016 @default.
- W2096277721 countsByYear W20962777212017 @default.
- W2096277721 countsByYear W20962777212019 @default.
- W2096277721 countsByYear W20962777212020 @default.
- W2096277721 countsByYear W20962777212021 @default.
- W2096277721 crossrefType "journal-article" @default.
- W2096277721 hasAuthorship W2096277721A5015101570 @default.
- W2096277721 hasAuthorship W2096277721A5037988172 @default.