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• W2096295791 abstract "We have studied the fast relaxation kinetics of a small RNA hairpin tetraloop using time-resolved infrared spectroscopy. A laser-induced temperature jump initiated the relaxation by rapidly perturbing the thermal equilibrium of the sample. We probed the relaxation kinetics at two different wavenumbers, 1574 and 1669 cm−1. The latter is due to the C6═O6 carbonyl stretch of the base guanine and is a direct measure of guanine base pairing. The former is assigned to a ring vibration of guanine and tracks structure by sensing base stacking interactions. Overall, the kinetics at 1574 cm−1 are faster than those observed at 1669 cm−1. When relaxation occurs at the melting temperature, the kinetics at both wavenumbers are biexponential. When relaxation occurs at a temperature that is higher than the melting temperature, the data at 1669 cm−1 are still biexponential while only a single fast phase is resolved in the data at 1574 cm−1. The fast phases are in the range of microseconds, while the slower phases are in the range of tens of microseconds. At both wavenumbers, a portion of the relaxation is not resolved, indicating the existence of a very fast, sub-100 ns phase. Our results provide additional evidence that small, fast folding hairpin loops are characterized by a rugged energy landscape. Furthermore, our data suggest that single-strand stacking interactions and stacking interactions in the loop contribute significantly to the ruggedness of the energy landscape. This work also demonstrates the utility of time-resolved infrared spectroscopy in studying RNA folding." @default.
• W2096295791 created "2016-06-24" @default.
• W2096295791 creator A5026194029 @default.
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• W2096295791 date "2008-09-23" @default.
• W2096295791 modified "2023-10-06" @default.
• W2096295791 title "Rearrangement of Partially Ordered Stacked Conformations Contributes to the Rugged Energy Landscape of a Small RNA Hairpin" @default.
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• W2096295791 doi "https://doi.org/10.1021/bi801170c" @default.
• W2096295791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18808148" @default.
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