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- W2096317105 abstract "Generalized anxiety disorder (GAD) [ [1] Kessler R.C. Chiu W.T. Demler O. et al. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005; 62: 617-627 Crossref PubMed Scopus (8288) Google Scholar ] presents with an overall prevalence of 4–7%. Although available treatment is effective in many patients, treatment-resistance and low adherence due to adverse effects are some issues that compromise optimal treatment. In fact about 25% of patients reportedly fail to respond to treatment [ 2 Ballenger J.C. Panic disorder in primary care and general medicine. in: Rosenbaum J.F. Pollack M.H. Panic disorder and its treatment. Dekker Inc, New York1998: 1-36 Google Scholar , 3 Craske M.G. Edlund M.J. Sullivan G. et al. Perceived unmet need for mental health and barriers to among care patients with panic disorder. Psychiatr Serv. 2005; 56: 988-994 Crossref PubMed Scopus (50) Google Scholar ]. Brain stimulation techniques have shown promising results for anxiety symptoms [ 4 Zwanzger P. Fallgatter A.J. Zavorotnyy M. Padberg F. Anxiolytic effects of transcranial magnetic stimulation—an alternative treatment option in anxiety disorders?. J Neural Transm. 2009; 116: 767-775 Crossref PubMed Scopus (58) Google Scholar , 5 Shiozawa P. Leiva A.P. Castro C.D. et al. Transcranial Direct Current Stimulation (tDCS) for generalized anxiety disorder: a case study. Biol Psychiatry. 2014 Jun 1; 75: e17-e18 Abstract Full Text Full Text PDF PubMed Scopus (57) Google Scholar ]. Following previous results of different neuromodulation strategies, Trigeminal Nerve Stimulation (TNS) may also be able to exert anxiolytic effects in the clinical scenario. TNS is a non-invasive strategy based on the application of an low-energy electric signal to stimulate branches of the trigeminal nerve with further propagation of the stimuli toward brain areas related to mood and anxiety symptoms [ [6] Shiozawa P. Duailibi M.S. da Silva M.E. Cordeiro Q. Trigeminal nerve stimulation (TNS) protocol for treating major depression: an open-label proof-of-concept trial. Epilepsy Behav. 2014 Aug 19; 39C: 6-9 Abstract Full Text Full Text PDF Scopus (23) Google Scholar ]. TNS has been reported to reduce anxiety symptoms in patients with a primary diagnosis of major depression [ [7] Cook I.A. Schrader L.M. Degiorgio C.M. Miller P.R. Maremont E.R. Leuchter A.F. Trigeminal nerve stimulation in major depressive disorder: acute outcomes in an open pilot study. Epilepsy Behav. 2013 Aug; 28: 221-226 Abstract Full Text Full Text PDF PubMed Scopus (56) Google Scholar ] but has not been previously examined as a treatment for primary GAD." @default.
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- W2096317105 date "2015-05-01" @default.
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- W2096317105 title "Trigeminal Nerve Stimulation (TNS) for Generalized Anxiety Disorder: A Case Study" @default.
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