FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096317406> ?p ?o ?g. }

• W2096317406 endingPage "1940" @default.
• W2096317406 startingPage "1934" @default.
• W2096317406 abstract "Vascular endothelial cell growth factor (VEGF) binds to 2 related receptor tyrosine kinases, known as kinase insert domain-containing receptor (KDR) and fms-like tyrosine kinase (Flt-1). The KDR has been shown to mediate VEGF-stimulated endothelial cell mitogenesis, migration, and permeability. The Flt-1 receptor has been suggested to mediate VEGF-stimulated endothelial branching morphogenesis, a process whereby endothelial cells, in the presence of a 3D milieu composed of extracellular matrix components and a mixture of growth factors, undergo a morphological transition into a tubular network with many lumina. In the present study, we have used 2 independent endothelial cell tube formation models and highly selective VEGF mutants for the KDR and Flt-1 receptors. We demonstrate that KDR, not Flt-1, stimulation is responsible for the induction of endothelial tubulogenesis. In addition, we demonstrate a modulatory role for Flt-1 in VEGF-mediated tube formation. We also report that VEGF-driven endothelial tube formation is inhibited by selective inhibitors of mitogen-activated protein kinase activation and p38 protein kinase." @default.
• W2096317406 created "2016-06-24" @default.
• W2096317406 creator A5003514073 @default.
• W2096317406 creator A5012622147 @default.
• W2096317406 creator A5019992945 @default.
• W2096317406 creator A5024350755 @default.
• W2096317406 creator A5032358498 @default.
• W2096317406 creator A5034351013 @default.
• W2096317406 creator A5039637754 @default.
• W2096317406 creator A5055242543 @default.
• W2096317406 creator A5083581319 @default.
• W2096317406 date "2001-12-01" @default.
• W2096317406 modified "2023-10-17" @default.
• W2096317406 title "Vascular Endothelial Cell Growth Factor-Driven Endothelial Tube Formation Is Mediated by Vascular Endothelial Cell Growth Factor Receptor-2, a Kinase Insert Domain-Containing Receptor" @default.
• W2096317406 cites W1507160997 @default.
• W2096317406 cites W1529396499 @default.
• W2096317406 cites W1587020653 @default.
• W2096317406 cites W1875554126 @default.
• W2096317406 cites W1965380392 @default.
• W2096317406 cites W1971915141 @default.
• W2096317406 cites W1980334238 @default.
• W2096317406 cites W1980969801 @default.
• W2096317406 cites W1983622721 @default.
• W2096317406 cites W1985712533 @default.
• W2096317406 cites W1986024946 @default.
• W2096317406 cites W1986308750 @default.
• W2096317406 cites W1986559037 @default.
• W2096317406 cites W1987644022 @default.
• W2096317406 cites W2000064849 @default.
• W2096317406 cites W2016300147 @default.
• W2096317406 cites W2030651159 @default.
• W2096317406 cites W2046516822 @default.
• W2096317406 cites W2074190587 @default.
• W2096317406 cites W2078083828 @default.
• W2096317406 cites W2079070267 @default.
• W2096317406 cites W2084947524 @default.
• W2096317406 cites W2087933507 @default.
• W2096317406 cites W2088796595 @default.
• W2096317406 cites W2091545748 @default.
• W2096317406 cites W2100542906 @default.
• W2096317406 cites W2111654463 @default.
• W2096317406 cites W2146787008 @default.
• W2096317406 cites W4249388929 @default.
• W2096317406 doi "https://doi.org/10.1161/hq1201.099432" @default.
• W2096317406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11742867" @default.
• W2096317406 hasPublicationYear "2001" @default.
• W2096317406 type Work @default.
• W2096317406 sameAs 2096317406 @default.
• W2096317406 citedByCount "55" @default.
• W2096317406 countsByYear W20963174062012 @default.
• W2096317406 countsByYear W20963174062013 @default.
• W2096317406 countsByYear W20963174062014 @default.
• W2096317406 countsByYear W20963174062015 @default.
• W2096317406 countsByYear W20963174062016 @default.
• W2096317406 countsByYear W20963174062018 @default.
• W2096317406 countsByYear W20963174062019 @default.
• W2096317406 countsByYear W20963174062021 @default.
• W2096317406 countsByYear W20963174062022 @default.
• W2096317406 countsByYear W20963174062023 @default.
• W2096317406 crossrefType "journal-article" @default.
• W2096317406 hasAuthorship W2096317406A5003514073 @default.
• W2096317406 hasAuthorship W2096317406A5012622147 @default.
• W2096317406 hasAuthorship W2096317406A5019992945 @default.
• W2096317406 hasAuthorship W2096317406A5024350755 @default.
• W2096317406 hasAuthorship W2096317406A5032358498 @default.
• W2096317406 hasAuthorship W2096317406A5034351013 @default.
• W2096317406 hasAuthorship W2096317406A5039637754 @default.
• W2096317406 hasAuthorship W2096317406A5055242543 @default.
• W2096317406 hasAuthorship W2096317406A5083581319 @default.
• W2096317406 hasBestOaLocation W20963174061 @default.
• W2096317406 hasConcept C101544691 @default.
• W2096317406 hasConcept C103041312 @default.
• W2096317406 hasConcept C123012128 @default.
• W2096317406 hasConcept C140800825 @default.
• W2096317406 hasConcept C146285616 @default.
• W2096317406 hasConcept C14858245 @default.
• W2096317406 hasConcept C150710994 @default.
• W2096317406 hasConcept C15215337 @default.
• W2096317406 hasConcept C167734588 @default.
• W2096317406 hasConcept C170493617 @default.
• W2096317406 hasConcept C180361614 @default.
• W2096317406 hasConcept C184235292 @default.
• W2096317406 hasConcept C185592680 @default.
• W2096317406 hasConcept C202751555 @default.
• W2096317406 hasConcept C2775960820 @default.
• W2096317406 hasConcept C2777025900 @default.
• W2096317406 hasConcept C42362537 @default.
• W2096317406 hasConcept C502942594 @default.
• W2096317406 hasConcept C55493867 @default.
• W2096317406 hasConcept C62478195 @default.
• W2096317406 hasConcept C79186569 @default.
• W2096317406 hasConcept C86803240 @default.
• W2096317406 hasConcept C95444343 @default.
• W2096317406 hasConceptScore W2096317406C101544691 @default.
• W2096317406 hasConceptScore W2096317406C103041312 @default.
• W2096317406 hasConceptScore W2096317406C123012128 @default.
• W2096317406 hasConceptScore W2096317406C140800825 @default.
• W2096317406 hasConceptScore W2096317406C146285616 @default.

• next