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• W2096337482 startingPage "2318" @default.
• W2096337482 abstract "ABSTRACT Kaposi's sarcoma-associated herpesvirus (KSHV)-infected cells express the latency-associated nuclear antigen (LANA) involved in the regulation of host and viral gene expression and maintenance of the KSHV latent episome. Performance of these diverse functions involves a 7-amino-acid chromatin-binding motif (CBM) situated at the amino terminus of LANA that is capable of binding directly to nucleosomes. LANA interacts with additional chromatin components, including methyl-CpG-binding protein 2 (MeCP2). Here, we show that the carboxy-terminal DNA-binding/dimerization domain of LANA provides the principal interaction with MeCP2 but that this association is modulated by the CBM. Both domains are required for LANA to colocalize with MeCP2 at chromocenters, regions of extensive pericentric heterochromatin that can be imaged by fluorescence microscopy. Within MeCP2, the methyl-CpG-binding domain (MBD) is the primary determinant for chromatin localization and acts together with the adjacent repression domains (the transcription repression domain [TRD] and the corepressor-interacting domain [CRID]) to redirect LANA to chromocenters. MeCP2 facilitates repression by LANA bound to the KSHV terminal repeats, a function that requires the MeCP2 C terminus in addition to the MBD and CRID/TRD. LANA and MeCP2 can also cooperate to stimulate transcription of the human E2F1 promoter, which lacks a LANA DNA-binding sequence, but this function requires both the N and C termini of LANA. The ability of LANA to establish multivalent interactions with histones and chromatin-binding proteins such as MeCP2 would enable LANA to direct regulatory complexes to specific chromosomal sites and thereby achieve stable reprogramming of cellular gene expression in latently infected cells." @default.
• W2096337482 created "2016-06-24" @default.
• W2096337482 creator A5034902241 @default.
• W2096337482 creator A5036408174 @default.
• W2096337482 creator A5037903899 @default.
• W2096337482 creator A5074846269 @default.
• W2096337482 date "2010-03-01" @default.
• W2096337482 modified "2023-09-26" @default.
• W2096337482 title "The Latency-Associated Nuclear Antigen Interacts with MeCP2 and Nucleosomes through Separate Domains" @default.
• W2096337482 cites W1559742681 @default.
• W2096337482 cites W1604210388 @default.
• W2096337482 cites W1754561827 @default.
• W2096337482 cites W1784857457 @default.
• W2096337482 cites W1965641444 @default.
• W2096337482 cites W1966092430 @default.
• W2096337482 cites W1966699631 @default.
• W2096337482 cites W1970035892 @default.
• W2096337482 cites W1977937666 @default.
• W2096337482 cites W1981525236 @default.
• W2096337482 cites W1985101509 @default.
• W2096337482 cites W1988760901 @default.
• W2096337482 cites W1991251689 @default.
• W2096337482 cites W1991952124 @default.
• W2096337482 cites W1995782808 @default.
• W2096337482 cites W2000073535 @default.
• W2096337482 cites W2005090865 @default.
• W2096337482 cites W2006224384 @default.
• W2096337482 cites W2009631763 @default.
• W2096337482 cites W2012929231 @default.
• W2096337482 cites W2013739925 @default.
• W2096337482 cites W2015353463 @default.
• W2096337482 cites W2018051857 @default.
• W2096337482 cites W2018138792 @default.
• W2096337482 cites W2020458592 @default.
• W2096337482 cites W2021522625 @default.
• W2096337482 cites W2024474048 @default.
• W2096337482 cites W2036966242 @default.
• W2096337482 cites W2039276157 @default.
• W2096337482 cites W2042269850 @default.
• W2096337482 cites W2053980011 @default.
• W2096337482 cites W2054190108 @default.
• W2096337482 cites W2054271458 @default.
• W2096337482 cites W2059866017 @default.
• W2096337482 cites W2066410692 @default.
• W2096337482 cites W2071580019 @default.
• W2096337482 cites W2072444389 @default.
• W2096337482 cites W2073825815 @default.
• W2096337482 cites W2076361283 @default.
• W2096337482 cites W2078579639 @default.
• W2096337482 cites W2078738843 @default.
• W2096337482 cites W2082281799 @default.
• W2096337482 cites W2082496903 @default.
• W2096337482 cites W2093078850 @default.
• W2096337482 cites W2093189184 @default.
• W2096337482 cites W2097493532 @default.
• W2096337482 cites W2097778167 @default.
• W2096337482 cites W2103620614 @default.
• W2096337482 cites W2110097906 @default.
• W2096337482 cites W2110599787 @default.
• W2096337482 cites W2113377321 @default.
• W2096337482 cites W2116119112 @default.
• W2096337482 cites W2119795320 @default.
• W2096337482 cites W2120214547 @default.
• W2096337482 cites W2120246830 @default.
• W2096337482 cites W2120628024 @default.
• W2096337482 cites W2122644537 @default.
• W2096337482 cites W2123422243 @default.
• W2096337482 cites W2127996002 @default.
• W2096337482 cites W2131831568 @default.
• W2096337482 cites W2132717657 @default.
• W2096337482 cites W2134447274 @default.
• W2096337482 cites W2136206805 @default.
• W2096337482 cites W2149469688 @default.
• W2096337482 cites W2154446973 @default.
• W2096337482 cites W2154855808 @default.
• W2096337482 cites W2155251296 @default.
• W2096337482 cites W2155298861 @default.
• W2096337482 cites W2155587524 @default.
• W2096337482 cites W2156656479 @default.
• W2096337482 cites W2159163386 @default.
• W2096337482 cites W2160352834 @default.
• W2096337482 cites W2165864695 @default.
• W2096337482 cites W2167322696 @default.
• W2096337482 cites W2168397438 @default.
• W2096337482 cites W2170096097 @default.
• W2096337482 cites W2172197806 @default.
• W2096337482 cites W4254613993 @default.
• W2096337482 doi "https://doi.org/10.1128/jvi.01097-09" @default.
• W2096337482 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2820923" @default.
• W2096337482 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20032179" @default.
• W2096337482 hasPublicationYear "2010" @default.
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