FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096350986> ?p ?o ?g. }

• W2096350986 endingPage "2457" @default.
• W2096350986 startingPage "2449" @default.
• W2096350986 abstract "Background— The development of atrium-selective antiarrhythmic agents is a current strategy for inhibiting atrial fibrillation (AF). The present study investigated whether the natural flavone acacetin from the traditional Chinese medicine Xuelianhua would be an atrium-selective anti-AF agent. Methods and Results— The effects of acacetin on human atrial ultrarapid delayed rectifier K + current ( I Kur ) and other cardiac ionic currents were studied with a whole-cell patch technique. Acacetin suppressed I Kur and the transient outward K + current (IC 50 3.2 and 9.2 μmol/L, respectively) and prolonged action potential duration in human atrial myocytes. The compound blocked the acetylcholine-activated K + current; however, it had no effect on the Na + current, L-type Ca 2+ current, or inward-rectifier K + current in guinea pig cardiac myocytes. Although acacetin caused a weak reduction in the hERG and hKCNQ1/hKCNE1 channels stably expressed in HEK 293 cells, it did not prolong the corrected QT interval in rabbit hearts. In anesthetized dogs, acacetin (5 mg/kg) prolonged the atrial effective refractory period in both the right and left atria 1 to 4 hours after intraduodenal administration without prolongation of the corrected QT interval, whereas sotalol at 5 mg/kg prolonged both the atrial effective refractory period and the corrected QT interval. Acacetin prevented AF induction at doses of 2.5 mg/kg (50%), 5 mg/kg (85.7%), and 10 mg/kg (85.7%). Sotalol 5 mg/kg also prevented AF induction (60%). Conclusions— The present study demonstrates that the natural compound acacetin is an atrium-selective agent that prolongs the atrial effective refractory period without prolonging the corrected QT interval and effectively prevents AF in anesthetized dogs after intraduodenal administration. These results indicate that oral acacetin is a promising atrium-selective agent for the treatment of AF." @default.
• W2096350986 created "2016-06-24" @default.
• W2096350986 creator A5002230693 @default.
• W2096350986 creator A5002430008 @default.
• W2096350986 creator A5009246282 @default.
• W2096350986 creator A5015403864 @default.
• W2096350986 creator A5018541150 @default.
• W2096350986 creator A5024583148 @default.
• W2096350986 creator A5026462731 @default.
• W2096350986 creator A5034490073 @default.
• W2096350986 creator A5037752753 @default.
• W2096350986 creator A5038402015 @default.
• W2096350986 creator A5051228732 @default.
• W2096350986 creator A5054712138 @default.
• W2096350986 creator A5064129295 @default.
• W2096350986 creator A5065770366 @default.
• W2096350986 creator A5076765345 @default.
• W2096350986 creator A5079644094 @default.
• W2096350986 creator A5079969251 @default.
• W2096350986 date "2008-05-13" @default.
• W2096350986 modified "2023-10-15" @default.
• W2096350986 title "Acacetin, a Natural Flavone, Selectively Inhibits Human Atrial Repolarization Potassium Currents and Prevents Atrial Fibrillation in Dogs" @default.
• W2096350986 cites W1964008401 @default.
• W2096350986 cites W1970415212 @default.
• W2096350986 cites W1972281362 @default.
• W2096350986 cites W1973299783 @default.
• W2096350986 cites W1974805894 @default.
• W2096350986 cites W1979000106 @default.
• W2096350986 cites W1981853673 @default.
• W2096350986 cites W1982578924 @default.
• W2096350986 cites W1985479046 @default.
• W2096350986 cites W1989353631 @default.
• W2096350986 cites W1998083759 @default.
• W2096350986 cites W2014743555 @default.
• W2096350986 cites W2017452554 @default.
• W2096350986 cites W2020150227 @default.
• W2096350986 cites W2037565673 @default.
• W2096350986 cites W2059294202 @default.
• W2096350986 cites W2063344460 @default.
• W2096350986 cites W2063619843 @default.
• W2096350986 cites W2083348840 @default.
• W2096350986 cites W2083470764 @default.
• W2096350986 cites W2085347267 @default.
• W2096350986 cites W2089293776 @default.
• W2096350986 cites W2099007790 @default.
• W2096350986 cites W2100635876 @default.
• W2096350986 cites W2103751952 @default.
• W2096350986 cites W2114871525 @default.
• W2096350986 cites W2117386147 @default.
• W2096350986 cites W2124955276 @default.
• W2096350986 cites W2130114624 @default.
• W2096350986 cites W2137434301 @default.
• W2096350986 cites W2163921362 @default.
• W2096350986 cites W2165880289 @default.
• W2096350986 cites W2168364326 @default.
• W2096350986 cites W2202621324 @default.
• W2096350986 cites W2314286570 @default.
• W2096350986 cites W4239476259 @default.
• W2096350986 doi "https://doi.org/10.1161/circulationaha.108.769554" @default.
• W2096350986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18458165" @default.
• W2096350986 hasPublicationYear "2008" @default.
• W2096350986 type Work @default.
• W2096350986 sameAs 2096350986 @default.
• W2096350986 citedByCount "111" @default.
• W2096350986 countsByYear W20963509862012 @default.
• W2096350986 countsByYear W20963509862013 @default.
• W2096350986 countsByYear W20963509862014 @default.
• W2096350986 countsByYear W20963509862015 @default.
• W2096350986 countsByYear W20963509862016 @default.
• W2096350986 countsByYear W20963509862017 @default.
• W2096350986 countsByYear W20963509862018 @default.
• W2096350986 countsByYear W20963509862019 @default.
• W2096350986 countsByYear W20963509862020 @default.
• W2096350986 countsByYear W20963509862021 @default.
• W2096350986 countsByYear W20963509862022 @default.
• W2096350986 countsByYear W20963509862023 @default.
• W2096350986 crossrefType "journal-article" @default.
• W2096350986 hasAuthorship W2096350986A5002230693 @default.
• W2096350986 hasAuthorship W2096350986A5002430008 @default.
• W2096350986 hasAuthorship W2096350986A5009246282 @default.
• W2096350986 hasAuthorship W2096350986A5015403864 @default.
• W2096350986 hasAuthorship W2096350986A5018541150 @default.
• W2096350986 hasAuthorship W2096350986A5024583148 @default.
• W2096350986 hasAuthorship W2096350986A5026462731 @default.
• W2096350986 hasAuthorship W2096350986A5034490073 @default.
• W2096350986 hasAuthorship W2096350986A5037752753 @default.
• W2096350986 hasAuthorship W2096350986A5038402015 @default.
• W2096350986 hasAuthorship W2096350986A5051228732 @default.
• W2096350986 hasAuthorship W2096350986A5054712138 @default.
• W2096350986 hasAuthorship W2096350986A5064129295 @default.
• W2096350986 hasAuthorship W2096350986A5065770366 @default.
• W2096350986 hasAuthorship W2096350986A5076765345 @default.
• W2096350986 hasAuthorship W2096350986A5079644094 @default.
• W2096350986 hasAuthorship W2096350986A5079969251 @default.
• W2096350986 hasBestOaLocation W20963509861 @default.
• W2096350986 hasConcept C114021368 @default.
• W2096350986 hasConcept C118441451 @default.
• W2096350986 hasConcept C126322002 @default.

• next