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• W2096378434 abstract "Losing and then regaining flagella The ability to adapt to changes in the function of gene regulators, as opposed to structural genes, is a crucial aspect of evolutionary change. Taylor et al. mutated a central regulator for the formation of flagella in the bacterium Pseudomonas fluorescens . They then put the mutated flagella-free bacteria under strong selection pressure to regain mobility. The mutated bacteria regained the lost flagella, and motility, within 4 days. Two stereotypical mutations diverted an evolutionarily related regulator that normally controls nitrogen uptake to control flagella biosynthesis. The mutations increased the levels of the co-opted regulator, then altered its specificity for the flagella pathway. Science , this issue p. 1014" @default.
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• W2096378434 date "2015-02-27" @default.
• W2096378434 modified "2023-10-18" @default.
• W2096378434 title "Evolutionary resurrection of flagellar motility via rewiring of the nitrogen regulation system" @default.
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• W2096378434 doi "https://doi.org/10.1126/science.1259145" @default.
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