FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096397910> ?p ?o ?g. }

• W2096397910 endingPage "5828" @default.
• W2096397910 startingPage "5821" @default.
• W2096397910 abstract "Abstract Whether thymic dendritic cells (DC) are phenotypically and functionally distinct from the monocyte lineage DC is an important question. Human thymic progenitors differentiate into T, NK, and DC. The latter induce clonal deletion of autoreactive thymocytes and therefore might be different from their monocyte-derived counterparts. The cytokines needed for the differentiation of DC from thymic progenitors were also questioned, particularly the need for GM-CSF. We show that various cytokine combinations with or without GM-CSF generated DC from CD34+CD1a− but not from CD34+CD1a+ thymocytes. CD34+ thymic cells generated far fewer DC than their counterparts from the cord blood. The requirement for IL-7 was strict whereas GM-CSF was dispensable but nonetheless improved the yield of DC. CD14+ monocytic intermediates were not detected in these cultures unless macrophage-CSF (M-CSF) was added. Cultures in M-CSF generated CD14−CD1a+ DC precursors but also CD14+CD1a− cells. When sorted and recultured in GM-CSF, CD14+ cells down-regulated CD14 and up-regulated CD1a. TNF-α accelerated the differentiation of progenitors into DC and augmented MHC class II transport to the membrane, resulting in improved capacity to induce MLR. The trafficking of MHC class II molecules was studied by metabolic labeling and immunoprecipitation. MHC class II molecules were transported to the membrane in association with invariant chain isoforms in CD14+ (monocyte)-derived and in CD1a+ thymic-derived DC but not in monocytes. Thus, thymic progenitors can differentiate into DC along a preferential CD1a+ pathway but have conserved a CD14+ maturation capacity under M-CSF. Finally, CD1a+-derived thymic DC and monocyte-derived DC share very close Ag-processing machinery." @default.
• W2096397910 created "2016-06-24" @default.
• W2096397910 creator A5004372035 @default.
• W2096397910 creator A5007030032 @default.
• W2096397910 creator A5055705796 @default.
• W2096397910 creator A5060855508 @default.
• W2096397910 creator A5079438343 @default.
• W2096397910 creator A5079455341 @default.
• W2096397910 date "1999-05-15" @default.
• W2096397910 modified "2023-10-16" @default.
• W2096397910 title "Functional and Phenotypic Analysis of Thymic CD34+CD1a− Progenitor-Derived Dendritic Cells: Predominance of CD1a+ Differentiation Pathway" @default.
• W2096397910 cites W1483922594 @default.
• W2096397910 cites W1489794538 @default.
• W2096397910 cites W153394692 @default.
• W2096397910 cites W1562670934 @default.
• W2096397910 cites W1575037337 @default.
• W2096397910 cites W1575774937 @default.
• W2096397910 cites W1661544713 @default.
• W2096397910 cites W1989645452 @default.
• W2096397910 cites W2019546595 @default.
• W2096397910 cites W2021780191 @default.
• W2096397910 cites W2022122015 @default.
• W2096397910 cites W2022807359 @default.
• W2096397910 cites W2028092080 @default.
• W2096397910 cites W2033541702 @default.
• W2096397910 cites W2039579933 @default.
• W2096397910 cites W2058796077 @default.
• W2096397910 cites W2060405001 @default.
• W2096397910 cites W2067938926 @default.
• W2096397910 cites W2071211232 @default.
• W2096397910 cites W2078957773 @default.
• W2096397910 cites W2095016279 @default.
• W2096397910 cites W2106241062 @default.
• W2096397910 cites W2108207978 @default.
• W2096397910 cites W2111360453 @default.
• W2096397910 cites W2111695773 @default.
• W2096397910 cites W2118099290 @default.
• W2096397910 cites W2121236896 @default.
• W2096397910 cites W2127404676 @default.
• W2096397910 cites W2131761283 @default.
• W2096397910 cites W2134364025 @default.
• W2096397910 cites W2142356948 @default.
• W2096397910 cites W2143048510 @default.
• W2096397910 cites W2159692449 @default.
• W2096397910 cites W2161792071 @default.
• W2096397910 cites W2167366928 @default.
• W2096397910 cites W2306296711 @default.
• W2096397910 cites W2402443265 @default.
• W2096397910 cites W2412368965 @default.
• W2096397910 cites W4235434271 @default.
• W2096397910 cites W4237676576 @default.
• W2096397910 cites W4240262570 @default.
• W2096397910 cites W90568390 @default.
• W2096397910 doi "https://doi.org/10.4049/jimmunol.162.10.5821" @default.
• W2096397910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10229816" @default.
• W2096397910 hasPublicationYear "1999" @default.
• W2096397910 type Work @default.
• W2096397910 sameAs 2096397910 @default.
• W2096397910 citedByCount "26" @default.
• W2096397910 countsByYear W20963979102014 @default.
• W2096397910 crossrefType "journal-article" @default.
• W2096397910 hasAuthorship W2096397910A5004372035 @default.
• W2096397910 hasAuthorship W2096397910A5007030032 @default.
• W2096397910 hasAuthorship W2096397910A5055705796 @default.
• W2096397910 hasAuthorship W2096397910A5060855508 @default.
• W2096397910 hasAuthorship W2096397910A5079438343 @default.
• W2096397910 hasAuthorship W2096397910A5079455341 @default.
• W2096397910 hasBestOaLocation W20963979101 @default.
• W2096397910 hasConcept C147483822 @default.
• W2096397910 hasConcept C201750760 @default.
• W2096397910 hasConcept C203014093 @default.
• W2096397910 hasConcept C207936829 @default.
• W2096397910 hasConcept C2778170410 @default.
• W2096397910 hasConcept C2778513237 @default.
• W2096397910 hasConcept C2778814158 @default.
• W2096397910 hasConcept C2781184567 @default.
• W2096397910 hasConcept C28328180 @default.
• W2096397910 hasConcept C553184892 @default.
• W2096397910 hasConcept C86803240 @default.
• W2096397910 hasConcept C95444343 @default.
• W2096397910 hasConceptScore W2096397910C147483822 @default.
• W2096397910 hasConceptScore W2096397910C201750760 @default.
• W2096397910 hasConceptScore W2096397910C203014093 @default.
• W2096397910 hasConceptScore W2096397910C207936829 @default.
• W2096397910 hasConceptScore W2096397910C2778170410 @default.
• W2096397910 hasConceptScore W2096397910C2778513237 @default.
• W2096397910 hasConceptScore W2096397910C2778814158 @default.
• W2096397910 hasConceptScore W2096397910C2781184567 @default.
• W2096397910 hasConceptScore W2096397910C28328180 @default.
• W2096397910 hasConceptScore W2096397910C553184892 @default.
• W2096397910 hasConceptScore W2096397910C86803240 @default.
• W2096397910 hasConceptScore W2096397910C95444343 @default.
• W2096397910 hasIssue "10" @default.
• W2096397910 hasLocation W20963979101 @default.
• W2096397910 hasLocation W20963979102 @default.
• W2096397910 hasOpenAccess W2096397910 @default.
• W2096397910 hasPrimaryLocation W20963979101 @default.
• W2096397910 hasRelatedWork W1585009187 @default.

• next