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- W2096408085 abstract "The use of radioactive seeds embedded in absorbable vicryl suture material has emerged as one preferred method for prostate cancer brachytherapy. While there are several practical advantages to the use of stranded sources, it is unclear how their displacement affects dosimetry. Our objective was to use CT imaging to determine strand displacement between day zero and day 30 scans and to assess the dosimetric consequences of strand displacement. Between 3/06 and 12/09 there were 87 prostate brachytherapy patients with day zero and day 30 post-plan imaging. Implants included 62 cases using I-125, 11 cases using Cs-131, and 14 cases using Pd-103. There were 9 to 28 strands per implant, and implants included between 3 and 28 loose seeds. On average, there were 72 seeds per implant (range of 48 to 105). Substantial strand displacement was identified by inspection. Migrated strands were identified on day 0 and day 30 scans and the distance of displacement was measured. Displacement was considered only in strands that had migrated away from the implant center. Dosimetric parameters (D90, D80, V200, V150, V100, urethra maximum, urethra mean, rectum maximum, rectum mean) were evaluated using CMS. Of the 1942 strands placed, 19 strands were found to have substantial migration. These displacements occurred in 18 of the 87 cases. The distance of strand displacement ranged from 0.5 cm to 2.5 cm, with an average of 1.5 cm. Of the displaced strands, 10 strands moved superior to the prostate and 9 strands moved inferior to the prostate. Between 1 and 4 seeds were lost in 27 cases. No considerable differences were found in post-implant day zero versus day 30 dosimetry. Comparisons between day zero and day 30 changes in dosimetry in seed displacement cases versus control cases also revealed no considerable dosimetric differences. Strand movement may be expected to occur in approximately 0.0098 percent of stranded sources and 20.69 percent of cases. Little dosimetric consequence is expected." @default.
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- W2096408085 date "2010-11-01" @default.
- W2096408085 modified "2023-09-27" @default.
- W2096408085 title "Measurement of Stranded Source Migration in Prostate Brachytherapy" @default.
- W2096408085 doi "https://doi.org/10.1016/j.ijrobp.2010.07.870" @default.
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