Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096429321> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2096429321 endingPage "583" @default.
- W2096429321 startingPage "576" @default.
- W2096429321 abstract "Teratozoospermia with unclear pathomechanism is one of the common causes for failed fertilisation. This study aimed to further explore the pathological mechanism for teratozoospermia. Spermatozoal transcript profiles generated from 13 normal fertile men and eight infertile males with a consistent severe heterogeneous teratozoospermia were used. These data were pre-processed, and differentially expressed genes were screened. Besides, gene ontology and pathway enrichment analysis were performed, and then, protein–protein interaction (PPI) network was constructed, and spermatogenesis-related genes in the PPI network were extracted. As a result, 366 up-regulated and 2158 down-regulated genes were identified. Multiple gene ontology terms and pathways including cell–cell signalling and reproduction enriched by differentially expressed genes were obtained. Moreover, four clusters including cluster 1 associated with RNA catabolic process were identified from the PPI network. In addition, genes including cyclin B1, proteasome (prosome, macropain) activator subunit 4, Rac GTPase-activating protein 1 and pituitary tumour-transforming 1 were received. In conclusion, abnormal expression of cyclin B1 and Rac GTPase-activating protein 1, still proteasome (prosome, macropain) activator subunit 4 and pituitary tumour-transforming 1 would impede cell cycle progression during sperm development and maturation, which may contribute to the occurrence and development of teratozoospermia." @default.
- W2096429321 created "2016-06-24" @default.
- W2096429321 creator A5000979495 @default.
- W2096429321 creator A5018073672 @default.
- W2096429321 creator A5029674626 @default.
- W2096429321 creator A5075604233 @default.
- W2096429321 date "2015-09-24" @default.
- W2096429321 modified "2023-09-28" @default.
- W2096429321 title "Identification of candidate causal genes and their associated pathogenic mechanisms underlying teratozoospermia based on the spermatozoa transcript profiles" @default.
- W2096429321 cites W1541407112 @default.
- W2096429321 cites W1546952499 @default.
- W2096429321 cites W1964409511 @default.
- W2096429321 cites W1980300512 @default.
- W2096429321 cites W1994842913 @default.
- W2096429321 cites W2005278541 @default.
- W2096429321 cites W2009774633 @default.
- W2096429321 cites W2016413776 @default.
- W2096429321 cites W2023577211 @default.
- W2096429321 cites W2036828685 @default.
- W2096429321 cites W2071756737 @default.
- W2096429321 cites W2078651069 @default.
- W2096429321 cites W2082565035 @default.
- W2096429321 cites W2082995757 @default.
- W2096429321 cites W2096943856 @default.
- W2096429321 cites W2098992097 @default.
- W2096429321 cites W2099278088 @default.
- W2096429321 cites W2103017472 @default.
- W2096429321 cites W2105924489 @default.
- W2096429321 cites W2108168487 @default.
- W2096429321 cites W2113923310 @default.
- W2096429321 cites W2116634113 @default.
- W2096429321 cites W2129147752 @default.
- W2096429321 cites W2140387883 @default.
- W2096429321 cites W2140685276 @default.
- W2096429321 cites W2143875754 @default.
- W2096429321 cites W2153358543 @default.
- W2096429321 cites W2159675211 @default.
- W2096429321 cites W2163451428 @default.
- W2096429321 cites W2167479330 @default.
- W2096429321 cites W2167530307 @default.
- W2096429321 cites W2595421406 @default.
- W2096429321 cites W4294216483 @default.
- W2096429321 doi "https://doi.org/10.1111/and.12484" @default.
- W2096429321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26404029" @default.
- W2096429321 hasPublicationYear "2015" @default.
- W2096429321 type Work @default.
- W2096429321 sameAs 2096429321 @default.
- W2096429321 citedByCount "7" @default.
- W2096429321 countsByYear W20964293212017 @default.
- W2096429321 countsByYear W20964293212018 @default.
- W2096429321 countsByYear W20964293212019 @default.
- W2096429321 countsByYear W20964293212022 @default.
- W2096429321 countsByYear W20964293212023 @default.
- W2096429321 crossrefType "journal-article" @default.
- W2096429321 hasAuthorship W2096429321A5000979495 @default.
- W2096429321 hasAuthorship W2096429321A5018073672 @default.
- W2096429321 hasAuthorship W2096429321A5029674626 @default.
- W2096429321 hasAuthorship W2096429321A5075604233 @default.
- W2096429321 hasBestOaLocation W20964293211 @default.
- W2096429321 hasConcept C104317684 @default.
- W2096429321 hasConcept C27740335 @default.
- W2096429321 hasConcept C54355233 @default.
- W2096429321 hasConcept C69991583 @default.
- W2096429321 hasConcept C86803240 @default.
- W2096429321 hasConceptScore W2096429321C104317684 @default.
- W2096429321 hasConceptScore W2096429321C27740335 @default.
- W2096429321 hasConceptScore W2096429321C54355233 @default.
- W2096429321 hasConceptScore W2096429321C69991583 @default.
- W2096429321 hasConceptScore W2096429321C86803240 @default.
- W2096429321 hasFunder F4320321001 @default.
- W2096429321 hasIssue "5" @default.
- W2096429321 hasLocation W20964293211 @default.
- W2096429321 hasLocation W20964293212 @default.
- W2096429321 hasOpenAccess W2096429321 @default.
- W2096429321 hasPrimaryLocation W20964293211 @default.
- W2096429321 hasRelatedWork W1516251615 @default.
- W2096429321 hasRelatedWork W2002128513 @default.
- W2096429321 hasRelatedWork W2029056863 @default.
- W2096429321 hasRelatedWork W2078815200 @default.
- W2096429321 hasRelatedWork W2171277769 @default.
- W2096429321 hasRelatedWork W2275577754 @default.
- W2096429321 hasRelatedWork W2385813177 @default.
- W2096429321 hasRelatedWork W2954044368 @default.
- W2096429321 hasRelatedWork W1592611938 @default.
- W2096429321 hasRelatedWork W2092874662 @default.
- W2096429321 hasVolume "48" @default.
- W2096429321 isParatext "false" @default.
- W2096429321 isRetracted "false" @default.
- W2096429321 magId "2096429321" @default.
- W2096429321 workType "article" @default.