FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096432005> ?p ?o ?g. }

• W2096432005 endingPage "600" @default.
• W2096432005 startingPage "600" @default.
• W2096432005 abstract "255 It has been shown that rhDnase improves lung function and reduces the incidence of pulmonary exacerbations in CF patients. However, very few data are available on the nutritional impact of rhDNase. The aim of this study was to evaluate the effect of rhDNase on nutritional status in CF patients during a 2-year follow-up. Patients and methods: From August 1994 to January 1995, rhDNase was started in 82 CF patients whatever their clinical condition, provided age≥5 years and forced vital capacity (FVC)≥40% predicted. The dose of rhDNase was 2.5 mg once daily. Thirteen patients were withdrawn for the following reasons: poor compliance (n=8) or intolerance to rhDNase (n=1), lung transplantation(n=1), lack of data (n=3). Baseline spirometric values (% predicted) and nutritional status of the 69 patients who completed the study (35 boys, 34 girls; mean age: 8.5 years; range: 5-16.4 years) were as follows: FVC: 84.8±21.7%; forced expiratory volume in 1 second (FEV1): 80.8±22.2%; Z score Weight/Height: -0.41±1.14; Z score Weight/Age: -0.48±1.25; Body Mass Index (BMI): 15.4±1.8; caloric intake: 107±25% of recommanded dietary allowances. Spirometric and nutritional data were analysed after 1, 3, 6, 12, 18 and 24 months of treatment and compared to baseline values. The number of oral and intravenous antibiotic courses and the Shwachman score were compared at baseline and after 2 years of treatment with rhDNase. No specific dietetic recommendations were given during the study period. Results: An improvement of lung function was observed after 1 month of treatment and was maintained throughout the following 2 years around 8.7%(6.4-11.4%) for FVC (p<0.01) and 8.2% (7.3-9.1%) for FEV1 (p<0.01). An increase in caloric intake was observed from the 3rd month (+ 6.3%, p<0.05) until the end of the 2nd year (+ 14.8%, p<0.01). During the year before the beginning of the study, a decrease of 8.3% in caloric intake had been observed. An increase of BMI was observed from the 6th month (15.7±1.7, p=0.02) until the end of the 2nd year (16.2±2.4, p<0.001). Z score Weight/Age increased significantly after only 3 months of treatment (+0.13, p<0.01) but gradually returned to baseline values thereafter whereas Z score Weight/Height only improved after 2 years (+0.19, p<0.05). Shwachman score remained unchanged after 2 years of treatment (89±10 vs 87±9 at baseline, NS) as well as the number of antibiotic courses/year(5.3±5.3 vs 5±5.8 at baseline, NS). Conclusion: In our population of CF patients with young age and mild to moderate lung disease, treatment with rhDNase was associated with an increase in caloric intake and an improvement of nutritional status. Nutritional impact of rhDNase is not related in our patients to a decrease of respiratory tract infections, the incidence of which remained stable during the study period." @default.
• W2096432005 created "2016-06-24" @default.
• W2096432005 creator A5010847427 @default.
• W2096432005 creator A5016504242 @default.
• W2096432005 creator A5017834658 @default.
• W2096432005 creator A5023917953 @default.
• W2096432005 creator A5030294967 @default.
• W2096432005 creator A5037845804 @default.
• W2096432005 creator A5049668648 @default.
• W2096432005 creator A5054386470 @default.
• W2096432005 creator A5056406461 @default.
• W2096432005 creator A5074756493 @default.
• W2096432005 creator A5087047716 @default.
• W2096432005 date "1998-05-01" @default.
• W2096432005 modified "2023-09-26" @default.
• W2096432005 title "NUTRITIONAL IMPACT OF RECOMBINANT HUMAN DEOXYRIBONUCLEASE (rhDNase) IN CYSTIC FIBROSIS (CF) PATIENTS" @default.
• W2096432005 doi "https://doi.org/10.1097/00005176-199805000-00264" @default.
• W2096432005 hasPublicationYear "1998" @default.
• W2096432005 type Work @default.
• W2096432005 sameAs 2096432005 @default.
• W2096432005 citedByCount "0" @default.
• W2096432005 crossrefType "journal-article" @default.
• W2096432005 hasAuthorship W2096432005A5010847427 @default.
• W2096432005 hasAuthorship W2096432005A5016504242 @default.
• W2096432005 hasAuthorship W2096432005A5017834658 @default.
• W2096432005 hasAuthorship W2096432005A5023917953 @default.
• W2096432005 hasAuthorship W2096432005A5030294967 @default.
• W2096432005 hasAuthorship W2096432005A5037845804 @default.
• W2096432005 hasAuthorship W2096432005A5049668648 @default.
• W2096432005 hasAuthorship W2096432005A5054386470 @default.
• W2096432005 hasAuthorship W2096432005A5056406461 @default.
• W2096432005 hasAuthorship W2096432005A5074756493 @default.
• W2096432005 hasAuthorship W2096432005A5087047716 @default.
• W2096432005 hasConcept C126322002 @default.
• W2096432005 hasConcept C165637977 @default.
• W2096432005 hasConcept C187212893 @default.
• W2096432005 hasConcept C2776042228 @default.
• W2096432005 hasConcept C2776938444 @default.
• W2096432005 hasConcept C2777714996 @default.
• W2096432005 hasConcept C2780221984 @default.
• W2096432005 hasConcept C2780333948 @default.
• W2096432005 hasConcept C3018587741 @default.
• W2096432005 hasConcept C55520419 @default.
• W2096432005 hasConcept C71924100 @default.
• W2096432005 hasConcept C75603125 @default.
• W2096432005 hasConcept C90924648 @default.
• W2096432005 hasConceptScore W2096432005C126322002 @default.
• W2096432005 hasConceptScore W2096432005C165637977 @default.
• W2096432005 hasConceptScore W2096432005C187212893 @default.
• W2096432005 hasConceptScore W2096432005C2776042228 @default.
• W2096432005 hasConceptScore W2096432005C2776938444 @default.
• W2096432005 hasConceptScore W2096432005C2777714996 @default.
• W2096432005 hasConceptScore W2096432005C2780221984 @default.
• W2096432005 hasConceptScore W2096432005C2780333948 @default.
• W2096432005 hasConceptScore W2096432005C3018587741 @default.
• W2096432005 hasConceptScore W2096432005C55520419 @default.
• W2096432005 hasConceptScore W2096432005C71924100 @default.
• W2096432005 hasConceptScore W2096432005C75603125 @default.
• W2096432005 hasConceptScore W2096432005C90924648 @default.
• W2096432005 hasIssue "5" @default.
• W2096432005 hasLocation W20964320051 @default.
• W2096432005 hasOpenAccess W2096432005 @default.
• W2096432005 hasPrimaryLocation W20964320051 @default.
• W2096432005 hasRelatedWork W2077451952 @default.
• W2096432005 hasRelatedWork W2109083194 @default.
• W2096432005 hasRelatedWork W2159144077 @default.
• W2096432005 hasRelatedWork W2793928880 @default.
• W2096432005 hasRelatedWork W3045714908 @default.
• W2096432005 hasRelatedWork W3083326166 @default.
• W2096432005 hasRelatedWork W3087241905 @default.
• W2096432005 hasRelatedWork W3172619218 @default.
• W2096432005 hasRelatedWork W173999847 @default.
• W2096432005 hasRelatedWork W2602935417 @default.
• W2096432005 hasVolume "26" @default.
• W2096432005 isParatext "false" @default.
• W2096432005 isRetracted "false" @default.
• W2096432005 magId "2096432005" @default.
• W2096432005 workType "article" @default.