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- W2096448639 abstract "During limbic epileptogenesis in vivo the dentate granule cells (DGCs) exhibit increased expression of brain-derived neurotrophic factor (BDNF), followed by striking morphologic plasticities, namely the formation of basal dendrites and the sprouting of mossy fibers. We hypothesized that increased expression of BDNF intrinsic to DGCs is sufficient to induce these plasticities. To test this hypothesis, we transfected DGCs in rat hippocampal slice cultures with BDNF or nerve growth factor (NGF) via particle-mediated gene transfer, and we visualized the neuronal processes with cotransfected green fluorescent protein. Transfection with BDNF produced significant increases in axonal branch and basal dendrite number relative to NGF or empty vector controls. Structural changes were prevented by the tyrosine kinase inhibitor K252a. Thus increased expression of BDNF within DGCs is sufficient to induce these morphological plasticities, which may represent one mechanism by which BDNF promotes limbic epileptogenesis." @default.
- W2096448639 created "2016-06-24" @default.
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- W2096448639 creator A5070835383 @default.
- W2096448639 creator A5085854141 @default.
- W2096448639 date "2002-11-15" @default.
- W2096448639 modified "2023-10-15" @default.
- W2096448639 title "Increased Expression of Brain-Derived Neurotrophic Factor Induces Formation of Basal Dendrites and Axonal Branching in Dentate Granule Cells in Hippocampal Explant Cultures" @default.
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- W2096448639 doi "https://doi.org/10.1523/jneurosci.22-22-09754.2002" @default.
- W2096448639 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6757848" @default.
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