FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096471937> ?p ?o ?g. }

• W2096471937 endingPage "2635" @default.
• W2096471937 startingPage "2631" @default.
• W2096471937 abstract "Background— Adenosine, a known mediator of preconditioning, has been infused into the coronary circulation to induce therapeutic preconditioning, eg, in preparation for angioplasty. However, results have been disappointing. We tested the hypothesis that endothelial nucleoside transporter acts as a barrier impeding the delivery of intravascular adenosine into the underlying myocardium and that this can be overcome with dipyridamole, a nucleoside transporter blocker. Methods and Results— We infused saline or adenosine (0.125 and 0.5 mg/min) into the brachial artery while monitoring forearm blood flow (FBF) and interstitial adenosine levels with microdialysis probes implanted in the flexor digitorum superficialis of the forearm in 7 healthy volunteers during intravenous administration of saline or dipyridamole (loading dose, 0.142 mg/kg per min for 5 minutes followed by 0.004 mg/kg per min). Adenosine produced near maximal forearm vasodilation, increasing FBF from 4.0±0.7 to 10.4±1.9 and 13.1±1.6 mL/100 mL per min for the low and high doses, respectively, but did not increase muscle dialysate adenosine concentration (from 88±21 to 65±23 and 85±26 nmol/L). Intravenous dipyridamole enhanced resting muscle dialysate adenosine (from 77±25 to 147±50 nmol/L), adenosine-induced increase in FBF (from 4.1±0.8 to 12.6±3 and 15.1±3 mL/100 mL per min for the low and high dose, respectively), and the delivery of adenosine into the interstitium (to 290±80 and 299±143 nmol/L for the low and high dose, respectively, P =0.04). Conclusions— Intravascular adenosine is likely ineffective in inducing myocardial preconditioning because of poor interstitial delivery. This can be overcome by blocking the nucleoside transporter with dipyridamole." @default.
• W2096471937 created "2016-06-24" @default.
• W2096471937 creator A5032394611 @default.
• W2096471937 creator A5061667911 @default.
• W2096471937 creator A5076447212 @default.
• W2096471937 creator A5077434880 @default.
• W2096471937 creator A5082646756 @default.
• W2096471937 creator A5084687186 @default.
• W2096471937 creator A5090068860 @default.
• W2096471937 creator A5090498263 @default.
• W2096471937 date "2003-11-25" @default.
• W2096471937 modified "2023-10-12" @default.
• W2096471937 title "Blockade of Nucleoside Transport Is Required for Delivery of Intraarterial Adenosine Into the Interstitium" @default.
• W2096471937 cites W109812290 @default.
• W2096471937 cites W1974085555 @default.
• W2096471937 cites W1993279024 @default.
• W2096471937 cites W1994243957 @default.
• W2096471937 cites W1999501161 @default.
• W2096471937 cites W2004086945 @default.
• W2096471937 cites W2004999698 @default.
• W2096471937 cites W2041393456 @default.
• W2096471937 cites W2064350371 @default.
• W2096471937 cites W2083708483 @default.
• W2096471937 cites W2083917900 @default.
• W2096471937 cites W2090767212 @default.
• W2096471937 cites W2129031759 @default.
• W2096471937 cites W2157275294 @default.
• W2096471937 cites W2269172808 @default.
• W2096471937 cites W2313071831 @default.
• W2096471937 cites W2317437510 @default.
• W2096471937 cites W2342173444 @default.
• W2096471937 cites W4238907943 @default.
• W2096471937 doi "https://doi.org/10.1161/01.cir.0000101927.70100.41" @default.
• W2096471937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14623808" @default.
• W2096471937 hasPublicationYear "2003" @default.
• W2096471937 type Work @default.
• W2096471937 sameAs 2096471937 @default.
• W2096471937 citedByCount "33" @default.
• W2096471937 countsByYear W20964719372012 @default.
• W2096471937 countsByYear W20964719372013 @default.
• W2096471937 countsByYear W20964719372016 @default.
• W2096471937 countsByYear W20964719372018 @default.
• W2096471937 countsByYear W20964719372020 @default.
• W2096471937 countsByYear W20964719372021 @default.
• W2096471937 crossrefType "journal-article" @default.
• W2096471937 hasAuthorship W2096471937A5032394611 @default.
• W2096471937 hasAuthorship W2096471937A5061667911 @default.
• W2096471937 hasAuthorship W2096471937A5076447212 @default.
• W2096471937 hasAuthorship W2096471937A5077434880 @default.
• W2096471937 hasAuthorship W2096471937A5082646756 @default.
• W2096471937 hasAuthorship W2096471937A5084687186 @default.
• W2096471937 hasAuthorship W2096471937A5090068860 @default.
• W2096471937 hasAuthorship W2096471937A5090498263 @default.
• W2096471937 hasBestOaLocation W20964719371 @default.
• W2096471937 hasConcept C120770815 @default.
• W2096471937 hasConcept C126322002 @default.
• W2096471937 hasConcept C170493617 @default.
• W2096471937 hasConcept C185592680 @default.
• W2096471937 hasConcept C2776543447 @default.
• W2096471937 hasConcept C2776890861 @default.
• W2096471937 hasConcept C2776991684 @default.
• W2096471937 hasConcept C2777397205 @default.
• W2096471937 hasConcept C2778938600 @default.
• W2096471937 hasConcept C42219234 @default.
• W2096471937 hasConcept C50156730 @default.
• W2096471937 hasConcept C529278444 @default.
• W2096471937 hasConcept C55493867 @default.
• W2096471937 hasConcept C67907053 @default.
• W2096471937 hasConcept C71924100 @default.
• W2096471937 hasConcept C98274493 @default.
• W2096471937 hasConceptScore W2096471937C120770815 @default.
• W2096471937 hasConceptScore W2096471937C126322002 @default.
• W2096471937 hasConceptScore W2096471937C170493617 @default.
• W2096471937 hasConceptScore W2096471937C185592680 @default.
• W2096471937 hasConceptScore W2096471937C2776543447 @default.
• W2096471937 hasConceptScore W2096471937C2776890861 @default.
• W2096471937 hasConceptScore W2096471937C2776991684 @default.
• W2096471937 hasConceptScore W2096471937C2777397205 @default.
• W2096471937 hasConceptScore W2096471937C2778938600 @default.
• W2096471937 hasConceptScore W2096471937C42219234 @default.
• W2096471937 hasConceptScore W2096471937C50156730 @default.
• W2096471937 hasConceptScore W2096471937C529278444 @default.
• W2096471937 hasConceptScore W2096471937C55493867 @default.
• W2096471937 hasConceptScore W2096471937C67907053 @default.
• W2096471937 hasConceptScore W2096471937C71924100 @default.
• W2096471937 hasConceptScore W2096471937C98274493 @default.
• W2096471937 hasIssue "21" @default.
• W2096471937 hasLocation W20964719371 @default.
• W2096471937 hasLocation W20964719372 @default.
• W2096471937 hasLocation W20964719373 @default.
• W2096471937 hasOpenAccess W2096471937 @default.
• W2096471937 hasPrimaryLocation W20964719371 @default.
• W2096471937 hasRelatedWork W1971106099 @default.
• W2096471937 hasRelatedWork W1978857055 @default.
• W2096471937 hasRelatedWork W1985223881 @default.
• W2096471937 hasRelatedWork W2039914241 @default.
• W2096471937 hasRelatedWork W2279356461 @default.
• W2096471937 hasRelatedWork W2408145031 @default.

• next