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- W2096474990 abstract "In ruminants, conceptus interferon-τ (IFNT) alters maternal physiology to accommodate a pregnancy. We hypothesized that the effectiveness of IFNT on extending corpus luteum (CL) life span in nonpregnant ewes would depend upon the dose and manner of administration and would be correlated with the response in gene expression in endometrium. We anticipated that IFNT, whether administered im or by uterine infusion, would mimic changes observed in pregnancy. Ewes were assigned to five treatments: 1) uterine infusion of saline; 2) uterine infusion of ovine IFNT4 (200 μg/d); 3) saline im injection; 4) im injection of IFNT4 at low dose (200 μg/d); and 5) high dose (2 mg/d). CL life span was increased in groups 2 and 5, but not in 1, 3, and 4. Endometrial RNA extracted from groups 1–5 on d 14 and from d 14 pregnant and nonbred (cyclic) ewes was used to assess expression of 70 genes on microarrays. When pregnant and cyclic ewes were compared, 30 genes were up-regulated and nine down-regulated during pregnancy. Resp..." @default.
- W2096474990 created "2016-06-24" @default.
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- W2096474990 date "2006-05-01" @default.
- W2096474990 modified "2023-09-27" @default.
- W2096474990 title "Effect of Interferon-τ Administration on Endometrium of Nonpregnant Ewes: A Comparison with Pregnant Ewes" @default.
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- W2096474990 doi "https://doi.org/10.1210/en.2005-1310" @default.
- W2096474990 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16469802" @default.
- W2096474990 hasPublicationYear "2006" @default.
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