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- W2096475134 abstract "A method is described for the extraction of ticrynafen, a new hypotensive agent, and its reduced metabolite from serum and urine. Drug-related material is extracted from biological fluids with ether under strongly acidic conditions and then back-extracted into an alkaline aqueous phase, which is subjected to high-pressure liquid chromatographic analysis. Separations are performed on a reversed-phase column with a mobile phase consisting of phosphate buffer-acetonitrile. This accurate and reproducible method measures serum concentrations of ticrynafen and its reduced metabolite as low as 1.0 and 0.4 microgram/ml, respectively." @default.
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- W2096475134 date "1979-11-01" @default.
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- W2096475134 title "High-pressure Liquid Chromatographic analysis of Ticrynafen and one of its Metabolites in Urine and Serum" @default.
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- W2096475134 doi "https://doi.org/10.1002/jps.2600681131" @default.
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