Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096481282> ?p ?o ?g. }
- W2096481282 endingPage "893" @default.
- W2096481282 startingPage "887" @default.
- W2096481282 abstract "The process of angiogenesis plays an important role in many physiological and pathological conditions. Inhibition of endothelial cell (EC) apoptosis providing EC survival is thought to be an essential mechanism during angiogenesis. Many of the angiogenic growth factors inhibit EC apoptosis. In addition, the adhesion of ECs to the extracellular matrix or intercellular adhesion promotes EC survival. In contrast, increasing evidence suggests that the induction of EC apoptosis may counteract angiogenesis. In this review, we focus on the regulation of EC survival and apoptosis during angiogenesis and especially on the effects and intracellular signaling promoted by angiogenic growth factors, endogenous angiogenic inhibitors (such as angiostatin, endostatin, and thrombospondin-1), and the adhesion to the extracellular matrix. Furthermore, we discuss the effects of cross talk between adhesion molecules and growth factors. Understanding the molecular mechanisms involved in the regulation of EC survival and apoptosis may provide new targets for the development of new therapies to enhance angiogenesis in the case of tissue-ischemia (eg, the neovascularization of myocardium) or to inhibit angiogenesis in the case of neovascularization-dependent disease (eg, tumor, diabetic retinopathy)." @default.
- W2096481282 created "2016-06-24" @default.
- W2096481282 creator A5022309505 @default.
- W2096481282 creator A5025706940 @default.
- W2096481282 date "2002-06-01" @default.
- W2096481282 modified "2023-10-16" @default.
- W2096481282 title "Regulation of Endothelial Cell Survival and Apoptosis During Angiogenesis" @default.
- W2096481282 cites W1495287184 @default.
- W2096481282 cites W1510237891 @default.
- W2096481282 cites W1528247040 @default.
- W2096481282 cites W1549631663 @default.
- W2096481282 cites W1566059459 @default.
- W2096481282 cites W1569373357 @default.
- W2096481282 cites W1582963778 @default.
- W2096481282 cites W1607892649 @default.
- W2096481282 cites W1678800844 @default.
- W2096481282 cites W1783580437 @default.
- W2096481282 cites W1905978178 @default.
- W2096481282 cites W1963776052 @default.
- W2096481282 cites W1964424550 @default.
- W2096481282 cites W1966879486 @default.
- W2096481282 cites W1968431199 @default.
- W2096481282 cites W1970717080 @default.
- W2096481282 cites W1971353320 @default.
- W2096481282 cites W1973262582 @default.
- W2096481282 cites W1976451311 @default.
- W2096481282 cites W1978769760 @default.
- W2096481282 cites W1980969801 @default.
- W2096481282 cites W1982799013 @default.
- W2096481282 cites W1985804036 @default.
- W2096481282 cites W1985850927 @default.
- W2096481282 cites W1988307856 @default.
- W2096481282 cites W1990112424 @default.
- W2096481282 cites W1991463736 @default.
- W2096481282 cites W1994014733 @default.
- W2096481282 cites W1996430165 @default.
- W2096481282 cites W1998909889 @default.
- W2096481282 cites W2001753204 @default.
- W2096481282 cites W2003788548 @default.
- W2096481282 cites W2004104374 @default.
- W2096481282 cites W2004239325 @default.
- W2096481282 cites W2004806132 @default.
- W2096481282 cites W2011053169 @default.
- W2096481282 cites W2011403734 @default.
- W2096481282 cites W2022415270 @default.
- W2096481282 cites W2022718682 @default.
- W2096481282 cites W2024123705 @default.
- W2096481282 cites W2028466368 @default.
- W2096481282 cites W2029773366 @default.
- W2096481282 cites W2034842897 @default.
- W2096481282 cites W2039317622 @default.
- W2096481282 cites W2039791984 @default.
- W2096481282 cites W2040283898 @default.
- W2096481282 cites W2042333083 @default.
- W2096481282 cites W2043297474 @default.
- W2096481282 cites W2045247659 @default.
- W2096481282 cites W2046516822 @default.
- W2096481282 cites W2046553038 @default.
- W2096481282 cites W2051379819 @default.
- W2096481282 cites W2054572692 @default.
- W2096481282 cites W2059322719 @default.
- W2096481282 cites W2060334940 @default.
- W2096481282 cites W2064644581 @default.
- W2096481282 cites W2066888615 @default.
- W2096481282 cites W2067303475 @default.
- W2096481282 cites W2072928113 @default.
- W2096481282 cites W2081245927 @default.
- W2096481282 cites W2083540484 @default.
- W2096481282 cites W2089420293 @default.
- W2096481282 cites W2093498435 @default.
- W2096481282 cites W2094844458 @default.
- W2096481282 cites W2098573045 @default.
- W2096481282 cites W2102369096 @default.
- W2096481282 cites W2118440238 @default.
- W2096481282 cites W2118719170 @default.
- W2096481282 cites W2121548842 @default.
- W2096481282 cites W2124559417 @default.
- W2096481282 cites W2126830227 @default.
- W2096481282 cites W2131798870 @default.
- W2096481282 cites W2134771161 @default.
- W2096481282 cites W2135143455 @default.
- W2096481282 cites W2140459348 @default.
- W2096481282 cites W2141046053 @default.
- W2096481282 cites W2147176626 @default.
- W2096481282 cites W2152215024 @default.
- W2096481282 cites W2160811005 @default.
- W2096481282 cites W2167455663 @default.
- W2096481282 doi "https://doi.org/10.1161/01.atv.0000017728.55907.a9" @default.
- W2096481282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12067894" @default.
- W2096481282 hasPublicationYear "2002" @default.
- W2096481282 type Work @default.
- W2096481282 sameAs 2096481282 @default.
- W2096481282 citedByCount "241" @default.
- W2096481282 countsByYear W20964812822012 @default.
- W2096481282 countsByYear W20964812822013 @default.
- W2096481282 countsByYear W20964812822014 @default.
- W2096481282 countsByYear W20964812822015 @default.
- W2096481282 countsByYear W20964812822016 @default.