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• W2096517177 abstract "Retinal dopaminergic amacrine neurons (DA neurons) play a central role in reconfiguring retinal function according to prevailing illumination conditions, yet the mechanisms by which light regulates their activity are poorly understood. We investigated the means by which sustained light responses are evoked in DA neurons. Sustained light responses were driven by cationic currents and persisted in vitro and in vivo in the presence of L-AP4, a blocker of retinal ON-bipolar cells. Several characteristics of these L-AP4-resistant light responses suggested that they were driven by melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs), including long latencies, marked poststimulus persistence, and a peak spectral sensitivity of 478 nm. Furthermore, sustained DA neuron light responses, but not transient DA neuron responses, persisted in rod/cone degenerate retinas, in which ipRGCs account for virtually all remaining retinal phototransduction. Thus, ganglion-cell photoreceptors provide excitatory drive to DA neurons, most likely by way of the coramification of their dendrites and the processes of DA neurons in the inner plexiform layer. This unprecedented centrifugal outflow of ganglion-cell signals within the retina provides a novel basis for the restructuring of retinal circuits by light." @default.
• W2096517177 created "2016-06-24" @default.
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• W2096517177 date "2008-09-16" @default.
• W2096517177 modified "2023-10-12" @default.
• W2096517177 title "Intraretinal signaling by ganglion cell photoreceptors to dopaminergic amacrine neurons" @default.
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• W2096517177 doi "https://doi.org/10.1073/pnas.0803893105" @default.
• W2096517177 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2544598" @default.
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• W2096517177 hasPublicationYear "2008" @default.
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