FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096520757> ?p ?o ?g. }

• W2096520757 endingPage "930" @default.
• W2096520757 startingPage "922" @default.
• W2096520757 abstract "Smoking is a major risk factor for atherosclerosis. In this study, we evaluated the effects of benzo[a]pyrene (BaP, a prominent component of tobacco smoke) on the function and pro-inflammatory response of human endothelial progenitor cells (EPCs). EPCs were isolated from umbilical cord blood and treated with different concentrations (10, 20 and 50 µmol/l) of BaP. The proliferation, migration, adhesion and angiogenesis of BaP-treated EPCs were evaluated using the cell counting kit-8 (CCK-8), Transwell assay, adhesion assay and in vitro tube formation assay, respectively. The activation of nuclear factor-κB (NF-κB) was evaluated by measuring the mRNA expression of NF-κB p65 and p50 by real-time RT-PCR and NF-κB translocation assay. Reactive oxygen species (ROS) production was determined by the reduction of fluorescent 2',7'-dichlorofluorescein diacetate (DCFH-DA). The results demonstrated that BaP treatment significantly inhibited the proliferation, migration, adhesion and angiogenesis of EPCs in vitro. In addition, BaP induced the release of interleukin (IL)-1β and tumor necrosis factor-α from these cells. Moreover, the exposure of EPCs to BaP induced ROS generation and the activation of NF-κB. Experiments with EPCs pre-treated with pyrrolidine dithiocarbamate, an inhibitor of NF-κB, revealed that the BaP-mediated inhibition of proliferation, migration, adhesion and angiogenesis of EPCs is mainly regulated by NF-κB. Thus, tobacco smoke may induce oxidant-mediated stress responses in EPCs and impair their function via the activation of the NF-κB pathway." @default.
• W2096520757 created "2016-06-24" @default.
• W2096520757 creator A5002764545 @default.
• W2096520757 creator A5008127870 @default.
• W2096520757 creator A5009977502 @default.
• W2096520757 creator A5011530217 @default.
• W2096520757 creator A5026027448 @default.
• W2096520757 creator A5029748241 @default.
• W2096520757 creator A5033443429 @default.
• W2096520757 creator A5037937657 @default.
• W2096520757 creator A5042565416 @default.
• W2096520757 creator A5065524679 @default.
• W2096520757 creator A5073200500 @default.
• W2096520757 creator A5082572053 @default.
• W2096520757 creator A5087818066 @default.
• W2096520757 date "2013-02-26" @default.
• W2096520757 modified "2023-10-14" @default.
• W2096520757 title "Benzo[a]pyrene induces oxidative stress and endothelial progenitor cell dysfunction via the activation of the NF-κB pathway" @default.
• W2096520757 cites W1502896205 @default.
• W2096520757 cites W1965772932 @default.
• W2096520757 cites W1976291192 @default.
• W2096520757 cites W1993966022 @default.
• W2096520757 cites W1999579644 @default.
• W2096520757 cites W2020250111 @default.
• W2096520757 cites W2024324829 @default.
• W2096520757 cites W2024978560 @default.
• W2096520757 cites W2026407309 @default.
• W2096520757 cites W2039260817 @default.
• W2096520757 cites W2039695749 @default.
• W2096520757 cites W2040652515 @default.
• W2096520757 cites W2048569323 @default.
• W2096520757 cites W2048650447 @default.
• W2096520757 cites W2054909375 @default.
• W2096520757 cites W2056229778 @default.
• W2096520757 cites W2066963386 @default.
• W2096520757 cites W2068019939 @default.
• W2096520757 cites W2071746224 @default.
• W2096520757 cites W2073516904 @default.
• W2096520757 cites W2080196370 @default.
• W2096520757 cites W2085054959 @default.
• W2096520757 cites W2091674433 @default.
• W2096520757 cites W2096678608 @default.
• W2096520757 cites W2098743872 @default.
• W2096520757 cites W2098767125 @default.
• W2096520757 cites W2107922629 @default.
• W2096520757 cites W2108103389 @default.
• W2096520757 cites W2109773324 @default.
• W2096520757 cites W2111380936 @default.
• W2096520757 cites W2113117342 @default.
• W2096520757 cites W2123799914 @default.
• W2096520757 cites W2127872440 @default.
• W2096520757 cites W2128329009 @default.
• W2096520757 cites W2130761693 @default.
• W2096520757 cites W2137588621 @default.
• W2096520757 cites W2145684092 @default.
• W2096520757 cites W2148637873 @default.
• W2096520757 cites W2154935039 @default.
• W2096520757 cites W2163582403 @default.
• W2096520757 cites W2164466232 @default.
• W2096520757 cites W2164578725 @default.
• W2096520757 cites W2327589969 @default.
• W2096520757 doi "https://doi.org/10.3892/ijmm.2013.1288" @default.
• W2096520757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23446805" @default.
• W2096520757 hasPublicationYear "2013" @default.
• W2096520757 type Work @default.
• W2096520757 sameAs 2096520757 @default.
• W2096520757 citedByCount "57" @default.
• W2096520757 countsByYear W20965207572013 @default.
• W2096520757 countsByYear W20965207572015 @default.
• W2096520757 countsByYear W20965207572016 @default.
• W2096520757 countsByYear W20965207572017 @default.
• W2096520757 countsByYear W20965207572018 @default.
• W2096520757 countsByYear W20965207572019 @default.
• W2096520757 countsByYear W20965207572020 @default.
• W2096520757 countsByYear W20965207572021 @default.
• W2096520757 countsByYear W20965207572022 @default.
• W2096520757 countsByYear W20965207572023 @default.
• W2096520757 crossrefType "journal-article" @default.
• W2096520757 hasAuthorship W2096520757A5002764545 @default.
• W2096520757 hasAuthorship W2096520757A5008127870 @default.
• W2096520757 hasAuthorship W2096520757A5009977502 @default.
• W2096520757 hasAuthorship W2096520757A5011530217 @default.
• W2096520757 hasAuthorship W2096520757A5026027448 @default.
• W2096520757 hasAuthorship W2096520757A5029748241 @default.
• W2096520757 hasAuthorship W2096520757A5033443429 @default.
• W2096520757 hasAuthorship W2096520757A5037937657 @default.
• W2096520757 hasAuthorship W2096520757A5042565416 @default.
• W2096520757 hasAuthorship W2096520757A5065524679 @default.
• W2096520757 hasAuthorship W2096520757A5073200500 @default.
• W2096520757 hasAuthorship W2096520757A5082572053 @default.
• W2096520757 hasAuthorship W2096520757A5087818066 @default.
• W2096520757 hasBestOaLocation W20965207571 @default.
• W2096520757 hasConcept C114246631 @default.
• W2096520757 hasConcept C153911025 @default.
• W2096520757 hasConcept C185592680 @default.
• W2096520757 hasConcept C190283241 @default.
• W2096520757 hasConcept C201750760 @default.
• W2096520757 hasConcept C2776151105 @default.

• next