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- W2096528984 abstract "Abstract: Dextran (9 mg/ml incubate) was found to induce a serotonin (5-HT) release from isolated rat peritoneal mast cells of about 10% within an incubation period of 5 min. at 37°. The extent of release was not increased by using higher concentrations of dextran or by increasing the incubation period from 5 to 20 min. The dextran-induced release of 5-HT was increased to 50–60% when the mast cells were preincubated with phosphatidylserine (PS) in doses of 2.6–4.3 μg/ml incubate. Higher concentrations of PS alone induced a rapid 5-HT release of approximately 50–60%. The 5-HT release process studied was found to possess both similarities and dissimilarities with the previously described dextran-induced release process of histamine, also studied in isolated rat peritoneal mast cells. The results supported previous indirect evidence of a 5-HT release from mast cells in the early phase of the dextran-induced anaphylactoid reaction in the rat." @default.
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- W2096528984 date "2009-03-13" @default.
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- W2096528984 title "Dextran-Induced Release of Serotonin from Isolated Rat Peritoneal Mast Cells" @default.
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- W2096528984 doi "https://doi.org/10.1111/j.1600-0773.1980.tb01562.x" @default.
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