Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096543162> ?p ?o ?g. }
- W2096543162 endingPage "1342" @default.
- W2096543162 startingPage "1332" @default.
- W2096543162 abstract "Cell type-specific microtubules, such as the Sertoli cell microtubules and the manchette and flagellum microtubules of the spermatids, play essential roles in spermatogenesis. We identified the gene encoding E-MAP-115 (epithelial microtubule-associated protein of 115 kD) as a retinoic acid-inducible gene using gene trap mutagenesis in mouse embryonic stem cells. The gene trap insertion led to a null allele of the E-MAP-115 gene and, in agreement with its high expression in the testis, male mice homozygous for the mutation were sterile because of deformation of spermatid nuclei and subsequent gradual loss of germ cells. Consistent with a possible role for E-MAP-115 in stabilizing microtubules, microtubule associations in the mutant were morphologically abnormal in the manchette of spermatids and in Sertoli cells. We hypothesize that the abnormal microtubules in these two cell types are responsible for deformation of spermatid nuclei and germ cell loss, respectively, and indicate an essential role for E-MAP-115 in microtubule functions required for spermatogenesis." @default.
- W2096543162 created "2016-06-24" @default.
- W2096543162 creator A5013656966 @default.
- W2096543162 creator A5016059814 @default.
- W2096543162 creator A5028315121 @default.
- W2096543162 creator A5055101259 @default.
- W2096543162 creator A5081123077 @default.
- W2096543162 date "2000-06-01" @default.
- W2096543162 modified "2023-10-18" @default.
- W2096543162 title "<i>E-MAP-115</i>, encoding a microtubule-associated protein, is a retinoic acid-inducible gene required for spermatogenesis" @default.
- W2096543162 cites W1505358892 @default.
- W2096543162 cites W1826083366 @default.
- W2096543162 cites W1927684145 @default.
- W2096543162 cites W1960037944 @default.
- W2096543162 cites W1965993988 @default.
- W2096543162 cites W1966429208 @default.
- W2096543162 cites W1973726394 @default.
- W2096543162 cites W1977453035 @default.
- W2096543162 cites W1987861844 @default.
- W2096543162 cites W1999935629 @default.
- W2096543162 cites W2003104761 @default.
- W2096543162 cites W2007282100 @default.
- W2096543162 cites W2009739411 @default.
- W2096543162 cites W2014721239 @default.
- W2096543162 cites W2015171213 @default.
- W2096543162 cites W2015701953 @default.
- W2096543162 cites W2021287789 @default.
- W2096543162 cites W2021631914 @default.
- W2096543162 cites W2023893968 @default.
- W2096543162 cites W2025631499 @default.
- W2096543162 cites W2028869988 @default.
- W2096543162 cites W2032516003 @default.
- W2096543162 cites W2035912798 @default.
- W2096543162 cites W2052801016 @default.
- W2096543162 cites W2054727506 @default.
- W2096543162 cites W2066199533 @default.
- W2096543162 cites W2077407101 @default.
- W2096543162 cites W2078210518 @default.
- W2096543162 cites W2079747318 @default.
- W2096543162 cites W2080524329 @default.
- W2096543162 cites W2082103215 @default.
- W2096543162 cites W2093129457 @default.
- W2096543162 cites W2093321309 @default.
- W2096543162 cites W2096809883 @default.
- W2096543162 cites W2106520143 @default.
- W2096543162 cites W2106792546 @default.
- W2096543162 cites W2112995359 @default.
- W2096543162 cites W2125429880 @default.
- W2096543162 cites W2126713523 @default.
- W2096543162 cites W2136324858 @default.
- W2096543162 cites W2143949827 @default.
- W2096543162 cites W2146125957 @default.
- W2096543162 cites W2164400934 @default.
- W2096543162 cites W2164670229 @default.
- W2096543162 cites W2165175972 @default.
- W2096543162 cites W2167736300 @default.
- W2096543162 cites W2169027640 @default.
- W2096543162 cites W2184433261 @default.
- W2096543162 cites W2247182007 @default.
- W2096543162 cites W2416683610 @default.
- W2096543162 cites W4235535531 @default.
- W2096543162 doi "https://doi.org/10.1101/gad.14.11.1332" @default.
- W2096543162 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/316653" @default.
- W2096543162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10837026" @default.
- W2096543162 hasPublicationYear "2000" @default.
- W2096543162 type Work @default.
- W2096543162 sameAs 2096543162 @default.
- W2096543162 citedByCount "56" @default.
- W2096543162 countsByYear W20965431622014 @default.
- W2096543162 countsByYear W20965431622015 @default.
- W2096543162 countsByYear W20965431622016 @default.
- W2096543162 countsByYear W20965431622017 @default.
- W2096543162 countsByYear W20965431622018 @default.
- W2096543162 countsByYear W20965431622019 @default.
- W2096543162 countsByYear W20965431622020 @default.
- W2096543162 countsByYear W20965431622021 @default.
- W2096543162 countsByYear W20965431622022 @default.
- W2096543162 crossrefType "journal-article" @default.
- W2096543162 hasAuthorship W2096543162A5013656966 @default.
- W2096543162 hasAuthorship W2096543162A5016059814 @default.
- W2096543162 hasAuthorship W2096543162A5028315121 @default.
- W2096543162 hasAuthorship W2096543162A5055101259 @default.
- W2096543162 hasAuthorship W2096543162A5081123077 @default.
- W2096543162 hasBestOaLocation W20965431621 @default.
- W2096543162 hasConcept C104317684 @default.
- W2096543162 hasConcept C123765429 @default.
- W2096543162 hasConcept C134018914 @default.
- W2096543162 hasConcept C153911025 @default.
- W2096543162 hasConcept C20418707 @default.
- W2096543162 hasConcept C2777394357 @default.
- W2096543162 hasConcept C2779122487 @default.
- W2096543162 hasConcept C2781068068 @default.
- W2096543162 hasConcept C54355233 @default.
- W2096543162 hasConcept C86803240 @default.
- W2096543162 hasConcept C95444343 @default.
- W2096543162 hasConceptScore W2096543162C104317684 @default.
- W2096543162 hasConceptScore W2096543162C123765429 @default.
- W2096543162 hasConceptScore W2096543162C134018914 @default.