Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096546369> ?p ?o ?g. }
- W2096546369 abstract "Abstract Background Coeliac disease is a multifactorial inflammatory disorder of the intestine caused by ingestion of gluten in genetically susceptible individuals. Genes within the HLA-DQ locus are considered to contribute some 40% of the genetic influence on this disease. However, information on other disease causing genes is sparse. Since enterocytes are considered to play a central role in coeliac pathology, the aim of this study was to examine gene expression in a highly purified isolate of these cells taken from patients with active disease. Epithelial cells were isolated from duodenal biopsies taken from five coeliac patients with active disease and five non-coeliac control subjects. Contaminating T cells were removed by magnetic sorting. The gene expression profile of the cells was examined using microarray analysis. Validation of significantly altered genes was performed by real-time RT-PCR and immunohistochemistry. Results Enterocyte suspensions of high purity (98–99%) were isolated from intestinal biopsies. Of the 3,800 genes investigated, 102 genes were found to have significantly altered expression between coeliac disease patients and controls (p < 0.05). Analysis of these altered genes revealed a number of biological processes that are potentially modified in active coeliac disease. These processes include events likely to contibute to coeliac pathology, such as altered cell proliferation, differentiation, survival, structure and transport. Conclusion This study provides a profile of the molecular changes that occur in the intestinal epithelium of coeliac patients with active disease. Novel candidate genes were revealed which highlight the contribution of the epithelial cell to the pathogenesis of coeliac disease." @default.
- W2096546369 created "2016-06-24" @default.
- W2096546369 creator A5000515741 @default.
- W2096546369 creator A5009675464 @default.
- W2096546369 creator A5049699439 @default.
- W2096546369 creator A5058259834 @default.
- W2096546369 creator A5088706285 @default.
- W2096546369 date "2008-08-08" @default.
- W2096546369 modified "2023-10-06" @default.
- W2096546369 title "Altered gene expression in highly purified enterocytes from patients with active coeliac disease" @default.
- W2096546369 cites W138598037 @default.
- W2096546369 cites W1568137751 @default.
- W2096546369 cites W1968334801 @default.
- W2096546369 cites W1970300861 @default.
- W2096546369 cites W1973469987 @default.
- W2096546369 cites W1975891446 @default.
- W2096546369 cites W1977265345 @default.
- W2096546369 cites W1980180569 @default.
- W2096546369 cites W1981622433 @default.
- W2096546369 cites W1982936276 @default.
- W2096546369 cites W1986754406 @default.
- W2096546369 cites W1987108454 @default.
- W2096546369 cites W1989089820 @default.
- W2096546369 cites W1991443138 @default.
- W2096546369 cites W1993677820 @default.
- W2096546369 cites W2007908883 @default.
- W2096546369 cites W2016603646 @default.
- W2096546369 cites W2017101487 @default.
- W2096546369 cites W2020003368 @default.
- W2096546369 cites W2023696892 @default.
- W2096546369 cites W2025346950 @default.
- W2096546369 cites W2027234544 @default.
- W2096546369 cites W2028797913 @default.
- W2096546369 cites W2031035500 @default.
- W2096546369 cites W2036329920 @default.
- W2096546369 cites W2036798664 @default.
- W2096546369 cites W2039588789 @default.
- W2096546369 cites W2045079777 @default.
- W2096546369 cites W2045824340 @default.
- W2096546369 cites W2047605880 @default.
- W2096546369 cites W2053405945 @default.
- W2096546369 cites W2059761425 @default.
- W2096546369 cites W2060142607 @default.
- W2096546369 cites W2060654250 @default.
- W2096546369 cites W2065483252 @default.
- W2096546369 cites W2065797000 @default.
- W2096546369 cites W2068725361 @default.
- W2096546369 cites W2073385776 @default.
- W2096546369 cites W2078446365 @default.
- W2096546369 cites W2078795510 @default.
- W2096546369 cites W2080248161 @default.
- W2096546369 cites W2087297634 @default.
- W2096546369 cites W2089168958 @default.
- W2096546369 cites W2093729681 @default.
- W2096546369 cites W2095632020 @default.
- W2096546369 cites W2097400398 @default.
- W2096546369 cites W2100449612 @default.
- W2096546369 cites W2104173530 @default.
- W2096546369 cites W2108397642 @default.
- W2096546369 cites W2110878879 @default.
- W2096546369 cites W2112182790 @default.
- W2096546369 cites W2123863320 @default.
- W2096546369 cites W2130918485 @default.
- W2096546369 cites W2131132948 @default.
- W2096546369 cites W2131989143 @default.
- W2096546369 cites W2133745600 @default.
- W2096546369 cites W2136580875 @default.
- W2096546369 cites W2138611060 @default.
- W2096546369 cites W2140606663 @default.
- W2096546369 cites W2146761817 @default.
- W2096546369 cites W2147569164 @default.
- W2096546369 cites W2148511724 @default.
- W2096546369 cites W2152252443 @default.
- W2096546369 cites W2159640265 @default.
- W2096546369 cites W2168643697 @default.
- W2096546369 cites W2187282265 @default.
- W2096546369 cites W2284018255 @default.
- W2096546369 cites W2315558598 @default.
- W2096546369 doi "https://doi.org/10.1186/1471-2164-9-377" @default.
- W2096546369 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2533024" @default.
- W2096546369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18691394" @default.
- W2096546369 hasPublicationYear "2008" @default.
- W2096546369 type Work @default.
- W2096546369 sameAs 2096546369 @default.
- W2096546369 citedByCount "38" @default.
- W2096546369 countsByYear W20965463692013 @default.
- W2096546369 countsByYear W20965463692014 @default.
- W2096546369 countsByYear W20965463692015 @default.
- W2096546369 countsByYear W20965463692016 @default.
- W2096546369 countsByYear W20965463692018 @default.
- W2096546369 countsByYear W20965463692019 @default.
- W2096546369 countsByYear W20965463692020 @default.
- W2096546369 countsByYear W20965463692021 @default.
- W2096546369 countsByYear W20965463692023 @default.
- W2096546369 crossrefType "journal-article" @default.
- W2096546369 hasAuthorship W2096546369A5000515741 @default.
- W2096546369 hasAuthorship W2096546369A5009675464 @default.
- W2096546369 hasAuthorship W2096546369A5049699439 @default.
- W2096546369 hasAuthorship W2096546369A5058259834 @default.
- W2096546369 hasAuthorship W2096546369A5088706285 @default.