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- W2096546937 abstract "Caspases are aspartate-specific cysteine proteases that have an essential role in apoptosis and inflammation, and contribute to the maintenance of homeostasis in the intestine. These facts, together with the knowledge that caspases are implicated in host-microbe crosstalk, prompted us to investigate the effect of caspase (Casp)1, -3 and -7 deficiency on the composition of the murine gut microbiota. We observed significant changes in the abundance of the Firmicutes and Bacteroidetes phyla, in particular the Lachnospiraceae, Porphyromonodaceae and Prevotellacea families, when comparing Casp-1, -7 and -3 knockout mice with wild-type mice. Our data point toward an intricate relationship between these caspases and the composition of the murine gut microflora." @default.
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- W2096546937 date "2011-10-20" @default.
- W2096546937 modified "2023-10-14" @default.
- W2096546937 title "Caspase deficiency alters the murine gut microbiome" @default.
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- W2096546937 doi "https://doi.org/10.1038/cddis.2011.101" @default.
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