FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096547892> ?p ?o ?g. }

• W2096547892 abstract "Summary The size of the pancreas is determined by intrinsic factors, such as the number of progenitor cells, and by extrinsic signals that control the fate and proliferation of those progenitors. Both the exocrine and endocrine compartments of the pancreas undergo dramatic expansion after birth, and are capable of at least partial regeneration following injury. Whether the expansion of these lineages relies on similar mechanisms is unknown. Although we have shown that the Wnt signaling component β-catenin is selectively required for generation of exocrine acinar cells in utero, this gene has been ascribed various functions in the postnatal pancreas including proliferation and regeneration of islet as well as acinar cells. To address whether β-catenin remains important for the maintenance and expansion of mature acinar cells, we have established a system to follow the behavior and fate of β-catenin-deficient cells during postnatal growth and regeneration. We find that β-catenin is continuously required for the establishment and maintenance of acinar cell mass, extending from embryonic specification through juvenile and adult self-renewal and regeneration. This requirement is not shared with islet cells, which proliferate and function normally in the absence of β-catenin. These results make distinct predictions for the relative role of Wnt/β-catenin signaling in the etiology of human endocrine and exocrine disease. We suggest that loss of Wnt/β-catenin activity is unlikely to drive islet dysfunction, as occurs in type 2 diabetes, but that β-catenin is likely to promote human acinar cell proliferation following injury, and may therefore contribute to the resolution of acute or chronic pancreatitis." @default.
• W2096547892 created "2016-06-24" @default.
• W2096547892 creator A5003013528 @default.
• W2096547892 creator A5014316809 @default.
• W2096547892 creator A5035946716 @default.
• W2096547892 creator A5042952989 @default.
• W2096547892 creator A5080071044 @default.
• W2096547892 creator A5090366405 @default.
• W2096547892 date "2012-01-01" @default.
• W2096547892 modified "2023-09-27" @default.
• W2096547892 title "Beta-catenin is selectively required for the expansion and regeneration of mature pancreatic acinar cells" @default.
• W2096547892 cites W1520222296 @default.
• W2096547892 cites W1617727899 @default.
• W2096547892 cites W1967081779 @default.
• W2096547892 cites W1967238067 @default.
• W2096547892 cites W1967543407 @default.
• W2096547892 cites W1969459168 @default.
• W2096547892 cites W1973758000 @default.
• W2096547892 cites W1982781304 @default.
• W2096547892 cites W1986829345 @default.
• W2096547892 cites W1987220381 @default.
• W2096547892 cites W1990518021 @default.
• W2096547892 cites W1990826732 @default.
• W2096547892 cites W1993055783 @default.
• W2096547892 cites W1993164825 @default.
• W2096547892 cites W1995812738 @default.
• W2096547892 cites W1995851961 @default.
• W2096547892 cites W2000499773 @default.
• W2096547892 cites W2006475805 @default.
• W2096547892 cites W2011070022 @default.
• W2096547892 cites W2011710385 @default.
• W2096547892 cites W2019384565 @default.
• W2096547892 cites W2022022842 @default.
• W2096547892 cites W2024176555 @default.
• W2096547892 cites W2033589713 @default.
• W2096547892 cites W2039086707 @default.
• W2096547892 cites W2041739600 @default.
• W2096547892 cites W2042978848 @default.
• W2096547892 cites W2050362176 @default.
• W2096547892 cites W2058073758 @default.
• W2096547892 cites W2058276161 @default.
• W2096547892 cites W2058368968 @default.
• W2096547892 cites W2060062579 @default.
• W2096547892 cites W2067906234 @default.
• W2096547892 cites W2080489534 @default.
• W2096547892 cites W2081263070 @default.
• W2096547892 cites W2084277057 @default.
• W2096547892 cites W2087276195 @default.
• W2096547892 cites W2088693506 @default.
• W2096547892 cites W2091523931 @default.
• W2096547892 cites W2094602845 @default.
• W2096547892 cites W2102743706 @default.
• W2096547892 cites W2103597610 @default.
• W2096547892 cites W2104740310 @default.
• W2096547892 cites W2105630842 @default.
• W2096547892 cites W2109627278 @default.
• W2096547892 cites W2111404063 @default.
• W2096547892 cites W2120647714 @default.
• W2096547892 cites W2122353449 @default.
• W2096547892 cites W2124018740 @default.
• W2096547892 cites W2128239138 @default.
• W2096547892 cites W2130112621 @default.
• W2096547892 cites W2132387165 @default.
• W2096547892 cites W2143291443 @default.
• W2096547892 cites W2148078342 @default.
• W2096547892 cites W2148147368 @default.
• W2096547892 cites W2148294117 @default.
• W2096547892 cites W2153361294 @default.
• W2096547892 cites W2156219329 @default.
• W2096547892 cites W2158300687 @default.
• W2096547892 cites W2158819616 @default.
• W2096547892 cites W2160400743 @default.
• W2096547892 cites W2165110092 @default.
• W2096547892 cites W2168721723 @default.
• W2096547892 cites W4229675390 @default.
• W2096547892 doi "https://doi.org/10.1242/dmm.007799" @default.
• W2096547892 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3380713" @default.
• W2096547892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22266944" @default.
• W2096547892 hasPublicationYear "2012" @default.
• W2096547892 type Work @default.
• W2096547892 sameAs 2096547892 @default.
• W2096547892 citedByCount "45" @default.
• W2096547892 countsByYear W20965478922012 @default.
• W2096547892 countsByYear W20965478922013 @default.
• W2096547892 countsByYear W20965478922014 @default.
• W2096547892 countsByYear W20965478922015 @default.
• W2096547892 countsByYear W20965478922016 @default.
• W2096547892 countsByYear W20965478922017 @default.
• W2096547892 countsByYear W20965478922018 @default.
• W2096547892 countsByYear W20965478922019 @default.
• W2096547892 countsByYear W20965478922020 @default.
• W2096547892 countsByYear W20965478922021 @default.
• W2096547892 countsByYear W20965478922022 @default.
• W2096547892 countsByYear W20965478922023 @default.
• W2096547892 crossrefType "journal-article" @default.
• W2096547892 hasAuthorship W2096547892A5003013528 @default.
• W2096547892 hasAuthorship W2096547892A5014316809 @default.
• W2096547892 hasAuthorship W2096547892A5035946716 @default.
• W2096547892 hasAuthorship W2096547892A5042952989 @default.
• W2096547892 hasAuthorship W2096547892A5080071044 @default.

• next