FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096549417> ?p ?o ?g. }

• W2096549417 endingPage "1648" @default.
• W2096549417 startingPage "1642" @default.
• W2096549417 abstract "Siglec-7 is a sialic acid binding receptor with inhibitory potential, expressed on human NK cells and monocytes. It has an unusual binding preference for α2,8-linked disialic acids, such as those displayed by ganglioside GD3. Here we have investigated whether siglec-7-GD3 interactions are able to modulate NK cell cytotoxicity. Using synthetic polyacrylamide glycoprobes, siglec-7 was found to be masked at the NK cell surface but it could be unmasked by sialidase treatment of NK cells. GD3 synthase-transfected P815 target cells expressed high levels of GD3 and bound strongly to recombinant siglec-7-Fc protein. Surprisingly, GD3 synthase-transfected P815 cells were killed more effectively by untreated cells in a siglec-7-independent manner. However, following sialidase treatment of NK cells, a siglec-7-dependent inhibition of killing was observed. These findings have important implications for NK cell cytotoxicity against tumor cells like melanoma that express high levels of GD3 ganglioside." @default.
• W2096549417 created "2016-06-24" @default.
• W2096549417 creator A5003449416 @default.
• W2096549417 creator A5047776373 @default.
• W2096549417 creator A5050858115 @default.
• W2096549417 creator A5055443704 @default.
• W2096549417 creator A5072230399 @default.
• W2096549417 creator A5091348150 @default.
• W2096549417 date "2003-06-01" @default.
• W2096549417 modified "2023-10-11" @default.
• W2096549417 title "Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanisms" @default.
• W2096549417 cites W1604400596 @default.
• W2096549417 cites W1917675481 @default.
• W2096549417 cites W1966056248 @default.
• W2096549417 cites W1975096725 @default.
• W2096549417 cites W1992619826 @default.
• W2096549417 cites W2000518846 @default.
• W2096549417 cites W2041196497 @default.
• W2096549417 cites W2042295667 @default.
• W2096549417 cites W2107170234 @default.
• W2096549417 cites W2115024349 @default.
• W2096549417 cites W2115806827 @default.
• W2096549417 cites W2119887491 @default.
• W2096549417 cites W2133776873 @default.
• W2096549417 cites W2148050927 @default.
• W2096549417 cites W2158004797 @default.
• W2096549417 cites W2163680099 @default.
• W2096549417 cites W2164993579 @default.
• W2096549417 cites W2281009136 @default.
• W2096549417 cites W326932590 @default.
• W2096549417 doi "https://doi.org/10.1002/eji.200323693" @default.
• W2096549417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12778482" @default.
• W2096549417 hasPublicationYear "2003" @default.
• W2096549417 type Work @default.
• W2096549417 sameAs 2096549417 @default.
• W2096549417 citedByCount "212" @default.
• W2096549417 countsByYear W20965494172012 @default.
• W2096549417 countsByYear W20965494172013 @default.
• W2096549417 countsByYear W20965494172014 @default.
• W2096549417 countsByYear W20965494172015 @default.
• W2096549417 countsByYear W20965494172016 @default.
• W2096549417 countsByYear W20965494172017 @default.
• W2096549417 countsByYear W20965494172018 @default.
• W2096549417 countsByYear W20965494172019 @default.
• W2096549417 countsByYear W20965494172020 @default.
• W2096549417 countsByYear W20965494172021 @default.
• W2096549417 countsByYear W20965494172022 @default.
• W2096549417 countsByYear W20965494172023 @default.
• W2096549417 crossrefType "journal-article" @default.
• W2096549417 hasAuthorship W2096549417A5003449416 @default.
• W2096549417 hasAuthorship W2096549417A5047776373 @default.
• W2096549417 hasAuthorship W2096549417A5050858115 @default.
• W2096549417 hasAuthorship W2096549417A5055443704 @default.
• W2096549417 hasAuthorship W2096549417A5072230399 @default.
• W2096549417 hasAuthorship W2096549417A5091348150 @default.
• W2096549417 hasBestOaLocation W20965494171 @default.
• W2096549417 hasConcept C109316439 @default.
• W2096549417 hasConcept C134164806 @default.
• W2096549417 hasConcept C1491633281 @default.
• W2096549417 hasConcept C153911025 @default.
• W2096549417 hasConcept C181199279 @default.
• W2096549417 hasConcept C202751555 @default.
• W2096549417 hasConcept C2777331542 @default.
• W2096549417 hasConcept C2778017598 @default.
• W2096549417 hasConcept C2780115458 @default.
• W2096549417 hasConcept C54009773 @default.
• W2096549417 hasConcept C54355233 @default.
• W2096549417 hasConcept C55493867 @default.
• W2096549417 hasConcept C73695083 @default.
• W2096549417 hasConcept C81885089 @default.
• W2096549417 hasConcept C86803240 @default.
• W2096549417 hasConcept C95444343 @default.
• W2096549417 hasConceptScore W2096549417C109316439 @default.
• W2096549417 hasConceptScore W2096549417C134164806 @default.
• W2096549417 hasConceptScore W2096549417C1491633281 @default.
• W2096549417 hasConceptScore W2096549417C153911025 @default.
• W2096549417 hasConceptScore W2096549417C181199279 @default.
• W2096549417 hasConceptScore W2096549417C202751555 @default.
• W2096549417 hasConceptScore W2096549417C2777331542 @default.
• W2096549417 hasConceptScore W2096549417C2778017598 @default.
• W2096549417 hasConceptScore W2096549417C2780115458 @default.
• W2096549417 hasConceptScore W2096549417C54009773 @default.
• W2096549417 hasConceptScore W2096549417C54355233 @default.
• W2096549417 hasConceptScore W2096549417C55493867 @default.
• W2096549417 hasConceptScore W2096549417C73695083 @default.
• W2096549417 hasConceptScore W2096549417C81885089 @default.
• W2096549417 hasConceptScore W2096549417C86803240 @default.
• W2096549417 hasConceptScore W2096549417C95444343 @default.
• W2096549417 hasIssue "6" @default.
• W2096549417 hasLocation W20965494171 @default.
• W2096549417 hasLocation W20965494172 @default.
• W2096549417 hasOpenAccess W2096549417 @default.
• W2096549417 hasPrimaryLocation W20965494171 @default.
• W2096549417 hasRelatedWork W1965310827 @default.
• W2096549417 hasRelatedWork W2014407487 @default.
• W2096549417 hasRelatedWork W2025927275 @default.
• W2096549417 hasRelatedWork W2055028888 @default.
• W2096549417 hasRelatedWork W2062490594 @default.

• next