FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096551536> ?p ?o ?g. }

• W2096551536 endingPage "1697" @default.
• W2096551536 startingPage "1689" @default.
• W2096551536 abstract "Abstract Selective depletion (SD) of host-reactive donor T cells from allogeneic stem-cell transplants (SCTs) using an anti-CD25 immunotoxin (IT) is a strategy to prevent acute graft-versus-host disease (aGvHD). There is concern that concurrent removal of regulatory T cells (Tregs) with incomplete removal of alloactivated CD25+ T cells could increase the risk of aGvHD. We therefore measured Tregs in the blood of 16 patients receiving a T-cell–depleted allograft together with anti–CD25-IT–treated SD lymphocytes, in 13 of their HLA-identical donors, and in 10 SD products. Tregs were characterized by intracellular staining for forkhead box protein 3 (FOXP3) and by quantitative reverse-transcription–polymerase chain reaction (qRT-PCR) for FOXP3 gene in CD4+ cells. Patients received a median of 1.0 × 108/kg SD T cells and a stem cell product containing a median of 0.25 × 104/kg residual T cells. Tregs reconstituted promptly after SCT and underwent further expansion. Of the CD4+ T cells in SD products, 1.5% to 4.8% were CD25− Tregs. Acute GvHD (≥ grade II) was restricted to 5 patients whose donors had significantly (P = .019) fewer Tregs compared with those without clinically significant aGvHD. These results suggest that rapid Treg reconstitution can occur following SD allografts, either from CD25− Tregs escaping depletion, or from residual CD25− and CD25+ Tregs contained in the stem-cell product that expand after transplantation and may confer additional protection against GvHD." @default.
• W2096551536 created "2016-06-24" @default.
• W2096551536 creator A5005077693 @default.
• W2096551536 creator A5006999192 @default.
• W2096551536 creator A5007244861 @default.
• W2096551536 creator A5022756369 @default.
• W2096551536 creator A5047120478 @default.
• W2096551536 creator A5049066393 @default.
• W2096551536 creator A5049107543 @default.
• W2096551536 creator A5050779664 @default.
• W2096551536 creator A5083701813 @default.
• W2096551536 creator A5084475433 @default.
• W2096551536 creator A5087980705 @default.
• W2096551536 creator A5088962035 @default.
• W2096551536 date "2007-09-01" @default.
• W2096551536 modified "2023-10-03" @default.
• W2096551536 title "Reconstitution of FOXP3+ regulatory T cells (Tregs) after CD25-depleted allotransplantion in elderly patients and association with acute graft-versus-host disease" @default.
• W2096551536 cites W1560562878 @default.
• W2096551536 cites W1977209916 @default.
• W2096551536 cites W1984709777 @default.
• W2096551536 cites W1986374907 @default.
• W2096551536 cites W1992638804 @default.
• W2096551536 cites W2002726823 @default.
• W2096551536 cites W2010186220 @default.
• W2096551536 cites W2013425867 @default.
• W2096551536 cites W2014888025 @default.
• W2096551536 cites W2019517733 @default.
• W2096551536 cites W2021603971 @default.
• W2096551536 cites W2027828569 @default.
• W2096551536 cites W2036736974 @default.
• W2096551536 cites W2041027155 @default.
• W2096551536 cites W2047511312 @default.
• W2096551536 cites W2062142808 @default.
• W2096551536 cites W2064252284 @default.
• W2096551536 cites W2068038112 @default.
• W2096551536 cites W2071112219 @default.
• W2096551536 cites W2078096787 @default.
• W2096551536 cites W2082841125 @default.
• W2096551536 cites W2085704445 @default.
• W2096551536 cites W2094292853 @default.
• W2096551536 cites W2095466773 @default.
• W2096551536 cites W2097811455 @default.
• W2096551536 cites W2098254750 @default.
• W2096551536 cites W2100088787 @default.
• W2096551536 cites W2104294740 @default.
• W2096551536 cites W2105079905 @default.
• W2096551536 cites W2105970563 @default.
• W2096551536 cites W2122722718 @default.
• W2096551536 cites W2124206153 @default.
• W2096551536 cites W2132289468 @default.
• W2096551536 cites W2138402880 @default.
• W2096551536 cites W2149936872 @default.
• W2096551536 cites W2157325100 @default.
• W2096551536 cites W2161152348 @default.
• W2096551536 cites W2164578725 @default.
• W2096551536 cites W2168740346 @default.
• W2096551536 cites W2316898638 @default.
• W2096551536 cites W2335677249 @default.
• W2096551536 cites W4232515381 @default.
• W2096551536 cites W4233066604 @default.
• W2096551536 cites W4313324526 @default.
• W2096551536 doi "https://doi.org/10.1182/blood-2007-03-079160" @default.
• W2096551536 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1975850" @default.
• W2096551536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17478639" @default.
• W2096551536 hasPublicationYear "2007" @default.
• W2096551536 type Work @default.
• W2096551536 sameAs 2096551536 @default.
• W2096551536 citedByCount "75" @default.
• W2096551536 countsByYear W20965515362012 @default.
• W2096551536 countsByYear W20965515362013 @default.
• W2096551536 countsByYear W20965515362014 @default.
• W2096551536 countsByYear W20965515362015 @default.
• W2096551536 countsByYear W20965515362016 @default.
• W2096551536 countsByYear W20965515362018 @default.
• W2096551536 countsByYear W20965515362019 @default.
• W2096551536 countsByYear W20965515362020 @default.
• W2096551536 countsByYear W20965515362022 @default.
• W2096551536 countsByYear W20965515362023 @default.
• W2096551536 crossrefType "journal-article" @default.
• W2096551536 hasAuthorship W2096551536A5005077693 @default.
• W2096551536 hasAuthorship W2096551536A5006999192 @default.
• W2096551536 hasAuthorship W2096551536A5007244861 @default.
• W2096551536 hasAuthorship W2096551536A5022756369 @default.
• W2096551536 hasAuthorship W2096551536A5047120478 @default.
• W2096551536 hasAuthorship W2096551536A5049066393 @default.
• W2096551536 hasAuthorship W2096551536A5049107543 @default.
• W2096551536 hasAuthorship W2096551536A5050779664 @default.
• W2096551536 hasAuthorship W2096551536A5083701813 @default.
• W2096551536 hasAuthorship W2096551536A5084475433 @default.
• W2096551536 hasAuthorship W2096551536A5087980705 @default.
• W2096551536 hasAuthorship W2096551536A5088962035 @default.
• W2096551536 hasBestOaLocation W20965515361 @default.
• W2096551536 hasConcept C115085202 @default.
• W2096551536 hasConcept C126322002 @default.
• W2096551536 hasConcept C159654299 @default.
• W2096551536 hasConcept C203014093 @default.
• W2096551536 hasConcept C2776090121 @default.
• W2096551536 hasConcept C2778296632 @default.

• next