FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096560368> ?p ?o ?g. }

• W2096560368 abstract "Inhaled endotoxin (LPS) may cause a transient increase in airway responsiveness, possibly through a cytokine-mediated airway inflammation, which is associated with an increase in nitric oxide synthesis and release.We wondered whether pentoxifylline (PTX), which may attenuate cytokine release induced by LPS, could inhibit LPS-induced increase in airway responsiveness.Methacholine (Mch) bronchial responsiveness was assessed 2 and 24 h after saline or LPS inhalation in eight subjects with bronchial hyperresponsiveness (PD20FEV1 610 +/- 53 micrograms), treated with iv saline or PTX, in a double-blind crossover design. Nitric oxide (NO) in the exhaled air, which was expected to increase after LPS inhalation, and PEFR values were also measured at baseline, hourly for 6 h and 24 h later.After LPS inhalation PEFR decreased significantly compared with placebo inhalation, reaching a maximum decrease of 11.25 +/- 1.05 and 4.5 +/- 0.84% of baseline, at 2 h, respectively during saline and PTX infusion, P < 0.001. Exhaled NO were elevated after LPS compared with placebo inhalation at 1 h (35.6 +/- 4.8 vs 18 +/- 2.8 ppb, P < 0.001), with no difference during saline or PTX infusion. Exhaled NO remained elevated until the 6th hour. PD20FEV1 2h after LPS inhalation was significantly lower than after placebo inhalation both during saline infusion (234 +/- 29 vs 625 +/- 62 micrograms, P < 0.001) and during PTX infusion (441 +/- 47 vs 616 +/- 48 micrograms, P < 0.001), the difference between saline and PTX being significant (P < 0.01). At 24 h no difference in PEFR, PD20FEV1 and exhaled NO was observed in comparison with pre-study values.PTX attenuates both the decrease in airway patency and the increase in bronchial responsiveness induced by LPS inhalation, without any significant change in exhaled NO, which is increased by LPS inhalation." @default.
• W2096560368 created "2016-06-24" @default.
• W2096560368 creator A5048041413 @default.
• W2096560368 creator A5052505482 @default.
• W2096560368 creator A5057000613 @default.
• W2096560368 creator A5060292739 @default.
• W2096560368 creator A5069606284 @default.
• W2096560368 creator A5080326198 @default.
• W2096560368 date "1997-01-01" @default.
• W2096560368 modified "2023-10-17" @default.
• W2096560368 title "Pentoxifylline attenuates LPS-induced bronchial hyperresponsiveness but not the increase in exhaled nitric oxide" @default.
• W2096560368 cites W1526590732 @default.
• W2096560368 cites W156046135 @default.
• W2096560368 cites W1984181944 @default.
• W2096560368 cites W1985737040 @default.
• W2096560368 cites W1989697230 @default.
• W2096560368 cites W1995873188 @default.
• W2096560368 cites W2003295582 @default.
• W2096560368 cites W2008202404 @default.
• W2096560368 cites W2011291552 @default.
• W2096560368 cites W2013394968 @default.
• W2096560368 cites W2017659011 @default.
• W2096560368 cites W2024804850 @default.
• W2096560368 cites W2032064406 @default.
• W2096560368 cites W2046446137 @default.
• W2096560368 cites W2047163318 @default.
• W2096560368 cites W2054433983 @default.
• W2096560368 cites W2058702543 @default.
• W2096560368 cites W2065762025 @default.
• W2096560368 cites W2068387381 @default.
• W2096560368 cites W2072648667 @default.
• W2096560368 cites W2074100262 @default.
• W2096560368 cites W2089538909 @default.
• W2096560368 cites W2101720275 @default.
• W2096560368 cites W2131113209 @default.
• W2096560368 cites W2152601580 @default.
• W2096560368 cites W2156886262 @default.
• W2096560368 cites W2164508592 @default.
• W2096560368 cites W2169653432 @default.
• W2096560368 cites W2319815243 @default.
• W2096560368 cites W4206163632 @default.
• W2096560368 cites W4232731661 @default.
• W2096560368 cites W2004252321 @default.
• W2096560368 doi "https://doi.org/10.1111/j.1365-2222.1997.tb00678.x" @default.
• W2096560368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9117888" @default.
• W2096560368 hasPublicationYear "1997" @default.
• W2096560368 type Work @default.
• W2096560368 sameAs 2096560368 @default.
• W2096560368 citedByCount "12" @default.
• W2096560368 countsByYear W20965603682013 @default.
• W2096560368 crossrefType "journal-article" @default.
• W2096560368 hasAuthorship W2096560368A5048041413 @default.
• W2096560368 hasAuthorship W2096560368A5052505482 @default.
• W2096560368 hasAuthorship W2096560368A5057000613 @default.
• W2096560368 hasAuthorship W2096560368A5060292739 @default.
• W2096560368 hasAuthorship W2096560368A5069606284 @default.
• W2096560368 hasAuthorship W2096560368A5080326198 @default.
• W2096560368 hasConcept C105922876 @default.
• W2096560368 hasConcept C126322002 @default.
• W2096560368 hasConcept C2776178081 @default.
• W2096560368 hasConcept C2776238763 @default.
• W2096560368 hasConcept C2776954882 @default.
• W2096560368 hasConcept C2777397205 @default.
• W2096560368 hasConcept C2777714996 @default.
• W2096560368 hasConcept C2778754761 @default.
• W2096560368 hasConcept C2780404050 @default.
• W2096560368 hasConcept C2780769369 @default.
• W2096560368 hasConcept C2781142857 @default.
• W2096560368 hasConcept C2781260171 @default.
• W2096560368 hasConcept C42219234 @default.
• W2096560368 hasConcept C519581460 @default.
• W2096560368 hasConcept C71924100 @default.
• W2096560368 hasConcept C98274493 @default.
• W2096560368 hasConceptScore W2096560368C105922876 @default.
• W2096560368 hasConceptScore W2096560368C126322002 @default.
• W2096560368 hasConceptScore W2096560368C2776178081 @default.
• W2096560368 hasConceptScore W2096560368C2776238763 @default.
• W2096560368 hasConceptScore W2096560368C2776954882 @default.
• W2096560368 hasConceptScore W2096560368C2777397205 @default.
• W2096560368 hasConceptScore W2096560368C2777714996 @default.
• W2096560368 hasConceptScore W2096560368C2778754761 @default.
• W2096560368 hasConceptScore W2096560368C2780404050 @default.
• W2096560368 hasConceptScore W2096560368C2780769369 @default.
• W2096560368 hasConceptScore W2096560368C2781142857 @default.
• W2096560368 hasConceptScore W2096560368C2781260171 @default.
• W2096560368 hasConceptScore W2096560368C42219234 @default.
• W2096560368 hasConceptScore W2096560368C519581460 @default.
• W2096560368 hasConceptScore W2096560368C71924100 @default.
• W2096560368 hasConceptScore W2096560368C98274493 @default.
• W2096560368 hasLocation W20965603681 @default.
• W2096560368 hasLocation W20965603682 @default.
• W2096560368 hasOpenAccess W2096560368 @default.
• W2096560368 hasPrimaryLocation W20965603681 @default.
• W2096560368 hasRelatedWork W1919304416 @default.
• W2096560368 hasRelatedWork W1967701449 @default.
• W2096560368 hasRelatedWork W1969601937 @default.
• W2096560368 hasRelatedWork W2032565543 @default.
• W2096560368 hasRelatedWork W2060833355 @default.
• W2096560368 hasRelatedWork W2096560368 @default.
• W2096560368 hasRelatedWork W2120364302 @default.

• next