Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096569605> ?p ?o ?g. }
- W2096569605 endingPage "1253" @default.
- W2096569605 startingPage "1248" @default.
- W2096569605 abstract "The effects of proton-pump inhibitors and Helicobacter pylori infection on the distribution of drugs employed for the eradication of H. pylori are poorly understood. The aim of this study was to investigate the effects of a 7-day oral administration of 20 mg omeprazole on the distribution of clarithromycin in the gastric juice of individuals with H. pylori infection.Eighteen H. pylori-infected dyspeptic male volunteers without endoscopic lesions were enrolled in a study with an open, randomized, two-period crossover design and a 21-day washout period between phases. Plasma and gastric juice concentrations of clarithromycin in subjects with and without omeprazole pretreatment were measured by means of liquid chromatography coupled to tandem mass spectrometry.The maximum concentration of clarithromycin (Cmax) and the area under the time-concentration curve from 0 to 2 h (AUC0-2h) were significantly higher in gastric juice than in plasma. Omeprazole treatment further augmented clarithromycin Cmax and AUC0-2h in gastric juice approximately 2-fold (P < 0.05).Short-term treatment with omeprazole in H. pylori-positive volunteers increases the amount of clarithromycin transferred to the gastric juice, confirming a synergism between these drugs. Our results suggest the presence of an active transport mechanism for clarithromycin from plasma to the gastric lumen, which is influenced by omeprazole." @default.
- W2096569605 created "2016-06-24" @default.
- W2096569605 creator A5003236378 @default.
- W2096569605 creator A5004500705 @default.
- W2096569605 creator A5012162768 @default.
- W2096569605 creator A5035662900 @default.
- W2096569605 creator A5044636969 @default.
- W2096569605 creator A5056435841 @default.
- W2096569605 creator A5062219769 @default.
- W2096569605 creator A5066175733 @default.
- W2096569605 creator A5068414692 @default.
- W2096569605 creator A5070586591 @default.
- W2096569605 creator A5072291569 @default.
- W2096569605 creator A5076700857 @default.
- W2096569605 date "2001-01-01" @default.
- W2096569605 modified "2023-09-27" @default.
- W2096569605 title "Transfer of Clarithromycin to Gastric Juice is Enhanced by Omeprazole in Helicobacter pylori -Infected Individuals" @default.
- W2096569605 cites W138002119 @default.
- W2096569605 cites W148880490 @default.
- W2096569605 cites W1963033896 @default.
- W2096569605 cites W1972939414 @default.
- W2096569605 cites W1975786498 @default.
- W2096569605 cites W1990997207 @default.
- W2096569605 cites W2003322692 @default.
- W2096569605 cites W2005670414 @default.
- W2096569605 cites W2012004433 @default.
- W2096569605 cites W2018374452 @default.
- W2096569605 cites W2023226683 @default.
- W2096569605 cites W2026994273 @default.
- W2096569605 cites W2027154143 @default.
- W2096569605 cites W2095279377 @default.
- W2096569605 cites W2101950652 @default.
- W2096569605 cites W2114903378 @default.
- W2096569605 cites W2136573621 @default.
- W2096569605 cites W2143124502 @default.
- W2096569605 cites W2144407579 @default.
- W2096569605 cites W2152771996 @default.
- W2096569605 cites W2158362878 @default.
- W2096569605 cites W2161598620 @default.
- W2096569605 cites W2163698869 @default.
- W2096569605 cites W2252991923 @default.
- W2096569605 cites W2413123101 @default.
- W2096569605 cites W2903140909 @default.
- W2096569605 cites W634847569 @default.
- W2096569605 cites W164300254 @default.
- W2096569605 doi "https://doi.org/10.1080/003655201317097074" @default.
- W2096569605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11761012" @default.
- W2096569605 hasPublicationYear "2001" @default.
- W2096569605 type Work @default.
- W2096569605 sameAs 2096569605 @default.
- W2096569605 citedByCount "17" @default.
- W2096569605 countsByYear W20965696052015 @default.
- W2096569605 countsByYear W20965696052021 @default.
- W2096569605 crossrefType "journal-article" @default.
- W2096569605 hasAuthorship W2096569605A5003236378 @default.
- W2096569605 hasAuthorship W2096569605A5004500705 @default.
- W2096569605 hasAuthorship W2096569605A5012162768 @default.
- W2096569605 hasAuthorship W2096569605A5035662900 @default.
- W2096569605 hasAuthorship W2096569605A5044636969 @default.
- W2096569605 hasAuthorship W2096569605A5056435841 @default.
- W2096569605 hasAuthorship W2096569605A5062219769 @default.
- W2096569605 hasAuthorship W2096569605A5066175733 @default.
- W2096569605 hasAuthorship W2096569605A5068414692 @default.
- W2096569605 hasAuthorship W2096569605A5070586591 @default.
- W2096569605 hasAuthorship W2096569605A5072291569 @default.
- W2096569605 hasAuthorship W2096569605A5076700857 @default.
- W2096569605 hasConcept C112705442 @default.
- W2096569605 hasConcept C126322002 @default.
- W2096569605 hasConcept C142724271 @default.
- W2096569605 hasConcept C185592680 @default.
- W2096569605 hasConcept C204787440 @default.
- W2096569605 hasConcept C22979827 @default.
- W2096569605 hasConcept C27081682 @default.
- W2096569605 hasConcept C2776409635 @default.
- W2096569605 hasConcept C2776962512 @default.
- W2096569605 hasConcept C2777498785 @default.
- W2096569605 hasConcept C2778677798 @default.
- W2096569605 hasConcept C2779137044 @default.
- W2096569605 hasConcept C2780832600 @default.
- W2096569605 hasConcept C2781025758 @default.
- W2096569605 hasConcept C3019249092 @default.
- W2096569605 hasConcept C501593827 @default.
- W2096569605 hasConcept C55493867 @default.
- W2096569605 hasConcept C71924100 @default.
- W2096569605 hasConcept C87813604 @default.
- W2096569605 hasConcept C90924648 @default.
- W2096569605 hasConcept C98274493 @default.
- W2096569605 hasConceptScore W2096569605C112705442 @default.
- W2096569605 hasConceptScore W2096569605C126322002 @default.
- W2096569605 hasConceptScore W2096569605C142724271 @default.
- W2096569605 hasConceptScore W2096569605C185592680 @default.
- W2096569605 hasConceptScore W2096569605C204787440 @default.
- W2096569605 hasConceptScore W2096569605C22979827 @default.
- W2096569605 hasConceptScore W2096569605C27081682 @default.
- W2096569605 hasConceptScore W2096569605C2776409635 @default.
- W2096569605 hasConceptScore W2096569605C2776962512 @default.
- W2096569605 hasConceptScore W2096569605C2777498785 @default.
- W2096569605 hasConceptScore W2096569605C2778677798 @default.