FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2096570055> ?p ?o ?g. }

• W2096570055 endingPage "901" @default.
• W2096570055 startingPage "900" @default.
• W2096570055 abstract "This editorial refers to “Genetic risk and gene–environment interaction in coronary artery spasm in Japanese men and women”1 by Y. Murase et al. on page 970The complexity of coronary artery disease genetics arises from the diversity of clinical phenotypes and from the many biological pathways that contribute to atherosclerotic plaque biology, including lipid metabolism, inflammation, endothelial function, oxidative stress and thrombosis. In addition to environmental factors, inter-individual variation in disease susceptibility or outcome may arise from common polymorphic variation in the genes encoding the proteins that participate in these and other biological pathways. Twin studies suggest that the total genetic contribution to coronary artery disease risk is substantial, but dissecting out the nature of these effects in a complex polygenic trait with multiple sub-phenotypes remains a major challenge.In this issue, Murase et al.1 have investigated possible associations between the presence of coronary artery spasm and 35 single nucleotide polymorphisms (SNPs) in 29 candidate genes. In comparing these SNPs in approximately 600 patients with coronary artery spasm with 1600 controls, they observed a significant association between coronary artery spasm in men and an SNP in the NAD(P)H oxidase p22phox gene, and in women with polymorphisms in the stromolysin-1 and interleukin-6 genes. These findings add weight to smaller case-control studies that have found associations between these and other biologically plausible candidate genes and phenotypes such as angiographic coronary artery disease, myocardial infarction or coronary artery spasm.2–4 A longstanding problem with many of these smaller case-control studies has … *Correspondence to: K.M. Channon, Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK. Tel.: +44-1865-741166/851085; fax: +44-1865-768844/222077
 E-mail address: keith.channon{at}cardiov.ox.ac.uk" @default.
• W2096570055 created "2016-06-24" @default.
• W2096570055 creator A5000195279 @default.
• W2096570055 creator A5033758288 @default.
• W2096570055 date "2004-06-01" @default.
• W2096570055 modified "2023-09-27" @default.
• W2096570055 title "Coronary artery disease genetics: bigger is better" @default.
• W2096570055 cites W1485668397 @default.
• W2096570055 cites W2052706283 @default.
• W2096570055 cites W2052952920 @default.
• W2096570055 cites W2069769149 @default.
• W2096570055 cites W2072763501 @default.
• W2096570055 cites W2090568412 @default.
• W2096570055 cites W2099172634 @default.
• W2096570055 cites W2109921650 @default.
• W2096570055 cites W2356450261 @default.
• W2096570055 doi "https://doi.org/10.1016/j.ehj.2004.04.013" @default.
• W2096570055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15172461" @default.
• W2096570055 hasPublicationYear "2004" @default.
• W2096570055 type Work @default.
• W2096570055 sameAs 2096570055 @default.
• W2096570055 citedByCount "4" @default.
• W2096570055 countsByYear W20965700552013 @default.
• W2096570055 countsByYear W20965700552015 @default.
• W2096570055 crossrefType "journal-article" @default.
• W2096570055 hasAuthorship W2096570055A5000195279 @default.
• W2096570055 hasAuthorship W2096570055A5033758288 @default.
• W2096570055 hasBestOaLocation W20965700551 @default.
• W2096570055 hasConcept C126322002 @default.
• W2096570055 hasConcept C164705383 @default.
• W2096570055 hasConcept C2778213512 @default.
• W2096570055 hasConcept C71924100 @default.
• W2096570055 hasConceptScore W2096570055C126322002 @default.
• W2096570055 hasConceptScore W2096570055C164705383 @default.
• W2096570055 hasConceptScore W2096570055C2778213512 @default.
• W2096570055 hasConceptScore W2096570055C71924100 @default.
• W2096570055 hasIssue "11" @default.
• W2096570055 hasLocation W20965700551 @default.
• W2096570055 hasLocation W20965700552 @default.
• W2096570055 hasOpenAccess W2096570055 @default.
• W2096570055 hasPrimaryLocation W20965700551 @default.
• W2096570055 hasRelatedWork W1987807347 @default.
• W2096570055 hasRelatedWork W2042629756 @default.
• W2096570055 hasRelatedWork W2057038702 @default.
• W2096570055 hasRelatedWork W2059961661 @default.
• W2096570055 hasRelatedWork W2471376028 @default.
• W2096570055 hasRelatedWork W2737884982 @default.
• W2096570055 hasRelatedWork W4220660297 @default.
• W2096570055 hasRelatedWork W4233159467 @default.
• W2096570055 hasRelatedWork W4237125075 @default.
• W2096570055 hasRelatedWork W2994454448 @default.
• W2096570055 hasVolume "25" @default.
• W2096570055 isParatext "false" @default.
• W2096570055 isRetracted "false" @default.
• W2096570055 magId "2096570055" @default.
• W2096570055 workType "article" @default.