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• W2096572066 abstract "Human normal spermatozoa present a specific chromatin organization, illustrated particularly by the non-random chromosome positioning. Spermatozoa with large vacuoles, described using motile sperm organelle morphology organization (MSOME), are associated with nuclear alterations, such as abnormal chromatin condensation and aneuploidy. To question a probable association between large nuclear vacuoles and chromatin disorganization, we evaluated chromosomes X, Y and 18 topography in normal spermatozoa (NS) compared with spermatozoa with large vacuoles (SLV). After centrifugation on a gradient density system, 229 NS (spermatozoa presenting a normal nuclear shape and a vacuole area <6.5% of head area) from 10 normal semen samples and 221 SLV (spermatozoa presenting a vacuole area >13% of head area) from 10 semen samples with teratozoospermia were selected using MSOME. A three-colour FISH was carried out using α-satellite centromeric probes for chromosomes X, Y and 18. For each chromosome, longitudinal and spatial positioning of centromeres was analysed. Distribution of each chromosome was non-random in NS and in SLV, whatever the methodology used. Using longitudinal positioning, distribution of chromosome 18 and chromosome Y centromeres did not differ significantly between SLV and NS. On the contrary, chromosome X centromeres were more frequently positioned in the posterior region of sperm nucleus in SLV (p = 0.01). Considering spatial positioning, distributions differed significantly between SN and SLV for chromosome Y (p = 0.02) and chromosome 18 (p < 10−4) and marginally for chromosome X (p = 0.08). Our study concluded to a modification in chromosomes X, Y and 18 centromere topography between NS and SLV, representing a novel and supplementary evidence to argue chromatin disorganization in SLV." @default.
• W2096572066 created "2016-06-24" @default.
• W2096572066 creator A5016681742 @default.
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• W2096572066 date "2012-10-09" @default.
• W2096572066 modified "2023-09-27" @default.
• W2096572066 title "Modification of chromosomal architecture in human spermatozoa with large vacuoles" @default.
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• W2096572066 cites W1964010516 @default.
• W2096572066 cites W1968960587 @default.
• W2096572066 cites W1977472233 @default.
• W2096572066 cites W1978194540 @default.
• W2096572066 cites W1990537694 @default.
• W2096572066 cites W2004992080 @default.
• W2096572066 cites W2015075186 @default.
• W2096572066 cites W2017737757 @default.
• W2096572066 cites W2024183626 @default.
• W2096572066 cites W2030937434 @default.
• W2096572066 cites W2037863817 @default.
• W2096572066 cites W2041465953 @default.
• W2096572066 cites W2047683782 @default.
• W2096572066 cites W2057092823 @default.
• W2096572066 cites W2057830591 @default.
• W2096572066 cites W2060879344 @default.
• W2096572066 cites W2060899209 @default.
• W2096572066 cites W2064219925 @default.
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• W2096572066 cites W2076543622 @default.
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• W2096572066 cites W2092624156 @default.
• W2096572066 cites W2093696229 @default.
• W2096572066 cites W2094942138 @default.
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• W2096572066 cites W2110169533 @default.
• W2096572066 cites W2112836820 @default.
• W2096572066 cites W2113861750 @default.
• W2096572066 cites W2114002362 @default.
• W2096572066 cites W2119411459 @default.
• W2096572066 cites W2120223828 @default.
• W2096572066 cites W2121627074 @default.
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• W2096572066 cites W2159377832 @default.
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• W2096572066 doi "https://doi.org/10.1111/j.2047-2927.2012.00016.x" @default.
• W2096572066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23258631" @default.
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