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- W2096572854 abstract "The ABCC6 gene encodes an organic anion transporter protein, ABCC6/MRP6. Mutations in the gene cause a rare, recessive genetic disease, pseudoxanthoma elasticum, while the loss of one ABCC6 allele is a genetic risk factor in coronary artery disease. We review here the information available on gene structure, evolution as well as the present knowledge on its transcriptional regulation. We give a detailed description of the characteristics of the protein, and analyze the relationship between the distributions of missense disease – causing mutations in the predicted threedimensional structure of the transporter, which suggests functional importance of the domain-domain interactions. Though neither the physiological function of the protein nor its role in the pathobiology of the diseases are known, a current hypothesis that ABCC6 may be involved in the efflux of one form of Vitamin K from the liver is discussed. Finally, we analyze potential strategies how the gene can be targeted on the transcriptional level to increase protein expression in order to compensate for reduced activity. In addition, pharmacologic correction of trafficking-defect mutants or suppression of stop codon mutations as potential future therapeutic interventions are also reviewed. Keywords: Genetic disease, connective tissue, cardiovascular, transcriptional regulation, calcification, vitamin K, membrane proteins, homology model, pseudoxanthoma elasticum, ABCC6" @default.
- W2096572854 created "2016-06-24" @default.
- W2096572854 creator A5028797359 @default.
- W2096572854 creator A5033639753 @default.
- W2096572854 creator A5041466906 @default.
- W2096572854 creator A5047764358 @default.
- W2096572854 creator A5082759449 @default.
- W2096572854 creator A5083791951 @default.
- W2096572854 date "2011-05-01" @default.
- W2096572854 modified "2023-10-16" @default.
- W2096572854 title "ABCC6 as a Target in Pseudoxanthoma Elasticum" @default.
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