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- W2096580557 abstract "The homeodomain protein alpha 2 and the SRF-like protein Mcm1 are required to establish cell type in the yeast Saccharomyces cerevisiae. Together, these regulatory proteins recognize a specific DNA operator, marking a set of genes for transcriptional repression. In this paper, we show that occupancy of the operator by alpha 2-Mcm1 is not sufficient to bring about repression. Rather, repression is effected only when Ssn6 (a TPR protein) and Tup1 (a beta-transducin repeat protein) are also present in the cell. We show that Ssn6 represses transcription when brought to a promoter by a bacterial DNA-binding domain and that Tup1 is required for this repression. Based on these and other results, we propose that Ssn6-Tup1 is a general repressor of transcription in yeast, recruited to target promoters by a variety of sequence-specific DNA-binding proteins." @default.
- W2096580557 created "2016-06-24" @default.
- W2096580557 creator A5000534641 @default.
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- W2096580557 creator A5041341228 @default.
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- W2096580557 date "1992-02-01" @default.
- W2096580557 modified "2023-09-27" @default.
- W2096580557 title "Ssn6-Tup1 is a general repressor of transcription in yeast" @default.
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- W2096580557 doi "https://doi.org/10.1016/0092-8674(92)90146-4" @default.
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