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- W2096594220 abstract "Steroid receptors bind to site-specific response elements in chromatin and modulate gene expression in a hormone-dependent fashion. With the use of a tandem array of mouse mammary tumor virus reporter elements and a form of glucocorticoid receptor labeled with green fluorescent protein, targeting of the receptor to response elements in live mouse cells was observed. Photobleaching experiments provide direct evidence that the hormone-occupied receptor undergoes rapid exchange between chromatin and the nucleoplasmic compartment. Thus, the interaction of regulatory proteins with target sites in chromatin is a more dynamic process than previously believed." @default.
- W2096594220 created "2016-06-24" @default.
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- W2096594220 date "2000-02-18" @default.
- W2096594220 modified "2023-10-18" @default.
- W2096594220 title "The Glucocorticoid Receptor: Rapid Exchange with Regulatory Sites in Living Cells" @default.
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- W2096594220 doi "https://doi.org/10.1126/science.287.5456.1262" @default.
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