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• W2096597075 abstract "The enzyme autotaxin (ATX) produces the lipid mediator LPA to stimulate cell migration and proliferation. The crystal structures of rat ATX, in its apo and inhibitor-bound forms, along with functional work, offer insight into substrate specificity and show that ATX interacts with integrins through one of its SMB domains. Autotaxin (ATX, also known as ectonucleotide pyrophosphatase/phosphodiesterase-2, ENPP2) is a secreted lysophospholipase D that generates the lipid mediator lysophosphatidic acid (LPA), a mitogen and chemoattractant for many cell types. ATX-LPA signaling is involved in various pathologies including tumor progression and inflammation. However, the molecular basis of substrate recognition and catalysis by ATX and the mechanism by which it interacts with target cells are unclear. Here, we present the crystal structure of ATX, alone and in complex with a small-molecule inhibitor. We have identified a hydrophobic lipid-binding pocket and mapped key residues for catalysis and selection between nucleotide and phospholipid substrates. We have shown that ATX interacts with cell-surface integrins through its N-terminal somatomedin B–like domains, using an atypical mechanism. Our results define determinants of substrate discrimination by the ENPP family, suggest how ATX promotes localized LPA signaling and suggest new approaches for targeting ATX with small-molecule therapeutic agents." @default.
• W2096597075 created "2016-06-24" @default.
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• W2096597075 date "2011-01-16" @default.
• W2096597075 modified "2023-10-02" @default.
• W2096597075 title "Structural basis of substrate discrimination and integrin binding by autotaxin" @default.
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• W2096597075 doi "https://doi.org/10.1038/nsmb.1980" @default.
• W2096597075 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3064516" @default.
• W2096597075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21240271" @default.
• W2096597075 hasPublicationYear "2011" @default.
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